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Protein
Submitted name:

Rab-related protein 4

Gene

Rab18

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • GTPase activity Source: FlyBase
  • GTP binding Source: InterPro

GO - Biological processi

  • cell adhesion Source: FlyBase
  • Rab protein signal transduction Source: FlyBase
  • regulation of cell shape Source: FlyBase
  • vesicle-mediated transport Source: FlyBase
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DME-6798695. Neutrophil degranulation.
R-DME-6811436. COPI-independent Golgi-to-ER retrograde traffic.
R-DME-8876198. RAB GEFs exchange GTP for GDP on RABs.

Names & Taxonomyi

Protein namesi
Submitted name:
Rab-related protein 4Imported
Gene namesi
Name:Rab18Imported
Synonyms:Rab-RP4Imported
ORF Names:CG3129Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0015794. Rab18.

Subcellular locationi

GO - Cellular componenti

  • early endosome Source: FlyBase
  • endoplasmic reticulum Source: FlyBase
  • Golgi apparatus Source: FlyBase
  • neuronal cell body Source: FlyBase
  • vesicle Source: FlyBase
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiO18337.
PRIDEiO18337.

Expressioni

Gene expression databases

BgeeiFBgn0015794.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0070814.

Structurei

3D structure databases

ProteinModelPortaliO18337.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG0080. Eukaryota.
ENOG410XPD0. LUCA.
HOGENOMiHOG000096258.
OrthoDBiEOG091G0MOO.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS00675. SIGMA54_INTERACT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O18337-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADRAIKLLV IGESGVGKSS LIRRFVENKF DQNHDVTIGM DFKSKVMQVD
60 70 80 90 100
GIDYKVALWD TAGAERFRSL TASFYRKALG AILVYDITSR DSLVKLETWL
110 120 130 140 150
AELDSYSDNP NIAIIVVGNK IDEERVVDRE EGRKFARKHR ALFIETSAKC
160 170 180 190
DQFVSDVFKD VVEKIVSSEY FNNGNASAGL DIASDRDLEA SASTCYC
Length:197
Mass (Da):22,038
Last modified:January 1, 1998 - v1
Checksum:i5A466314F9B740EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84317 mRNA. Translation: BAA21710.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84317 mRNA. Translation: BAA21710.1.

3D structure databases

ProteinModelPortaliO18337.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0070814.

Proteomic databases

PaxDbiO18337.
PRIDEiO18337.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0015794. Rab18.

Phylogenomic databases

eggNOGiKOG0080. Eukaryota.
ENOG410XPD0. LUCA.
HOGENOMiHOG000096258.
OrthoDBiEOG091G0MOO.

Enzyme and pathway databases

ReactomeiR-DME-6798695. Neutrophil degranulation.
R-DME-6811436. COPI-independent Golgi-to-ER retrograde traffic.
R-DME-8876198. RAB GEFs exchange GTP for GDP on RABs.

Gene expression databases

BgeeiFBgn0015794.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS00675. SIGMA54_INTERACT_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO18337_DROME
AccessioniPrimary (citable) accession number: O18337
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.