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Protein
Submitted name:

Drab11

Gene

Rab11

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • GTPase activating protein binding Source: FlyBase
  • GTPase activity Source: FlyBase
  • GTP binding Source: InterPro
  • protein complex binding Source: FlyBase

GO - Biological processi

  • actin cytoskeleton reorganization Source: FlyBase
  • actomyosin contractile ring contraction Source: FlyBase
  • adherens junction maintenance Source: FlyBase
  • antimicrobial humoral response Source: FlyBase
  • border follicle cell migration Source: FlyBase
  • cellularization Source: FlyBase
  • centrosome localization Source: FlyBase
  • chaeta development Source: FlyBase
  • compound eye development Source: FlyBase
  • compound eye morphogenesis Source: FlyBase
  • cortical actin cytoskeleton organization Source: FlyBase
  • dorsal closure Source: FlyBase
  • dorsal closure, amnioserosa morphology change Source: FlyBase
  • dorsal closure, elongation of leading edge cells Source: FlyBase
  • endocytosis Source: FlyBase
  • epithelium development Source: FlyBase
  • exosomal secretion Source: FlyBase
  • fusome organization Source: FlyBase
  • germarium-derived egg chamber formation Source: FlyBase
  • germ-line stem cell division Source: FlyBase
  • germ-line stem cell population maintenance Source: FlyBase
  • Golgi vesicle fusion to target membrane Source: FlyBase
  • male meiosis cytokinesis Source: FlyBase
  • negative regulation of synaptic growth at neuromuscular junction Source: FlyBase
  • oocyte development Source: FlyBase
  • oocyte microtubule cytoskeleton polarization Source: FlyBase
  • oogenesis Source: FlyBase
  • ovarian follicle cell development Source: FlyBase
  • ovarian fusome organization Source: FlyBase
  • positive regulation of Golgi to plasma membrane protein transport Source: FlyBase
  • Rab protein signal transduction Source: FlyBase
  • regulation of pole plasm oskar mRNA localization Source: FlyBase
  • regulation of synapse organization Source: FlyBase
  • rhabdomere development Source: FlyBase
  • sensory organ precursor cell fate determination Source: FlyBase
  • spermatocyte division Source: FlyBase
  • vesicle-mediated transport Source: FlyBase
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DME-5620916. VxPx cargo-targeting to cilium.

Names & Taxonomyi

Protein namesi
Submitted name:
Drab11Imported
Submitted name:
GM06568pImported
Submitted name:
RE11886pImported
Submitted name:
Rab11Imported
Submitted name:
Rab11, isoform AImported
Submitted name:
Rab11, isoform BImported
Gene namesi
Name:Rab11Imported
Synonyms:Drab11Imported
ORF Names:CG5771Imported, Dmel_CG5771Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0015790. Rab11.

Subcellular locationi

GO - Cellular componenti

  • autophagosome Source: FlyBase
  • cell pole Source: FlyBase
  • cleavage furrow Source: FlyBase
  • cytoplasm Source: FlyBase
  • cytoplasmic vesicle Source: FlyBase
  • endosome Source: FlyBase
  • fusome Source: FlyBase
  • Golgi apparatus Source: FlyBase
  • lipid particle Source: FlyBase
  • neuronal cell body Source: FlyBase
  • nuclear envelope Source: FlyBase
  • perinuclear region of cytoplasm Source: FlyBase
  • plasma membrane Source: FlyBase
  • recycling endosome Source: FlyBase
  • spindle envelope Source: FlyBase
  • synapse Source: FlyBase
  • terminal bouton Source: FlyBase
  • trans-Golgi network transport vesicle Source: FlyBase
  • vesicle Source: UniProtKB
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiFBgn0015790.

Interactioni

GO - Molecular functioni

  • GTPase activating protein binding Source: FlyBase
  • protein complex binding Source: FlyBase

Protein-protein interaction databases

DIPiDIP-47764N.
IntActiO18335. 3 interactors.
MINTiMINT-758893.
STRINGi7227.FBpp0083413.

Structurei

3D structure databases

ProteinModelPortaliO18335.
SMRiO18335.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG0087. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000118841.
KOiK07904.
OMAiETKQGCC.
OrthoDBiEOG091G0O1R.
PhylomeDBiO18335.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.

Sequencei

Sequence statusi: Complete.

O18335-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAREDEYDY LFKVVLIGDS GVGKSNLLSR FTRNEFNLES KSTIGVEFAT
60 70 80 90 100
RSIEVDGKTI KAQIWDTAGQ ERYRAITSAY YRGAVGALLV YDIAKHLTYE
110 120 130 140 150
NVERWLRELR DHADQNIVIM LVGNKSDLRH LRSVPTDEAK LFAERNGLSF
160 170 180 190 200
IETSALDSTN VETAFQNILT EIYRIVSQKQ IRDPPEGDVI RPSNVEPIDV
210
KPTVTADVRK QCCQ
Length:214
Mass (Da):24,245
Last modified:January 1, 1998 - v1
Checksum:i6033C911EFA74D89
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF55850.1.
AY070528 mRNA. Translation: AAL47999.1.
AY113404 mRNA. Translation: AAM29409.1.
AE014297 Genomic DNA. Translation: AAN13849.1.
D84315 mRNA. Translation: BAA21708.1.
AB035354 mRNA. Translation: BAA87880.1.
RefSeqiNP_477170.1. NM_057822.4.
NP_599137.1. NM_134310.3.
UniGeneiDm.3038.

Genome annotation databases

EnsemblMetazoaiFBtr0084010; FBpp0083413; FBgn0015790.
FBtr0084011; FBpp0083414; FBgn0015790.
GeneIDi42501.
KEGGidme:Dmel_CG5771.
UCSCiCG5771-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF55850.1.
AY070528 mRNA. Translation: AAL47999.1.
AY113404 mRNA. Translation: AAM29409.1.
AE014297 Genomic DNA. Translation: AAN13849.1.
D84315 mRNA. Translation: BAA21708.1.
AB035354 mRNA. Translation: BAA87880.1.
RefSeqiNP_477170.1. NM_057822.4.
NP_599137.1. NM_134310.3.
UniGeneiDm.3038.

3D structure databases

ProteinModelPortaliO18335.
SMRiO18335.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-47764N.
IntActiO18335. 3 interactors.
MINTiMINT-758893.
STRINGi7227.FBpp0083413.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0084010; FBpp0083413; FBgn0015790.
FBtr0084011; FBpp0083414; FBgn0015790.
GeneIDi42501.
KEGGidme:Dmel_CG5771.
UCSCiCG5771-RA. d. melanogaster.

Organism-specific databases

CTDi42501.
FlyBaseiFBgn0015790. Rab11.

Phylogenomic databases

eggNOGiKOG0087. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000118841.
KOiK07904.
OMAiETKQGCC.
OrthoDBiEOG091G0O1R.
PhylomeDBiO18335.

Enzyme and pathway databases

ReactomeiR-DME-5620916. VxPx cargo-targeting to cilium.

Miscellaneous databases

ChiTaRSiRab11. fly.
GenomeRNAii42501.

Gene expression databases

BgeeiFBgn0015790.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiO18335_DROME
AccessioniPrimary (citable) accession number: O18335
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 156 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.