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O18276 (GBRB_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Gamma-aminobutyric acid receptor subunit beta
Alternative name(s):
GABA(A) receptor subunit beta
Gene names
Name:gab-1
ORF Names:ZC482.1
OrganismCaenorhabditis elegans
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length550 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

GABA, an inhibitory neurotransmitter, mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel By similarity. Ref.1

Subcellular location

Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein By similarity. Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 550526Gamma-aminobutyric acid receptor subunit beta
PRO_0000255714

Regions

Topological domain25 – 264240Extracellular Potential
Transmembrane265 – 28521Helical; Potential
Transmembrane292 – 31120Helical; Potential
Transmembrane324 – 34421Helical; Potential
Topological domain345 – 527183Cytoplasmic Potential
Transmembrane528 – 54821Helical; Potential
Compositional bias355 – 3606Poly-Gly

Amino acid modifications

Glycosylation261N-linked (GlcNAc...) Potential
Glycosylation321N-linked (GlcNAc...) Potential
Glycosylation331N-linked (GlcNAc...) Potential
Glycosylation451N-linked (GlcNAc...) Potential
Glycosylation531N-linked (GlcNAc...) Potential
Glycosylation1931N-linked (GlcNAc...) Potential
Disulfide bond180 ↔ 194 By similarity

Experimental info

Sequence conflict161L → S in AAN65376. Ref.1
Sequence conflict1881P → S in AAN65376. Ref.1
Sequence conflict2671Q → E in AAN65376. Ref.1
Sequence conflict2731V → D in AAN65376. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O18276 [UniParc].

Last modified June 1, 2003. Version 3.
Checksum: 5DF089E1101438E5

FASTA55062,457
        10         20         30         40         50         60 
MRRSKTRRIF HVSITLLLVS TIFCQNGTKP HNNSTSDQMS SSWSNRSQTM YSNASSLLSD 

        70         80         90        100        110        120 
LLLDYDIRLR PGFGGDALLL TMDIIIASFD SISEVDMDYT LTMYLHQYWT DERLRWSNEI 

       130        140        150        160        170        180 
PIDEMTLSGE FSQNIWVPDT FLANDKHSYL HEVTERNKML RINVDGKVAY GMRLTSTLSC 

       190        200        210        220        230        240 
SMNLRNFPLD SQNCTVEIES YGYTTSEVLM KWNYPLAVHG VEQADVPQFT ITGFHTEDSI 

       250        260        270        280        290        300 
VSTATGSYQR LSLVFQLRRS VGYFIFQTYL PCVLIVMLSW VSFWINHEAT SARVALGITT 

       310        320        330        340        350        360 
VLTMTTISTG VRQSLPRISY VKSIDIYLVM CFVFVFAALL EYAAVNYSYW GRERGKGGGG 

       370        380        390        400        410        420 
NEWPVNGANK EDRESAVNVQ KWVPSGLMDG VPQPQDRRVE ALEEAMSTSN TAAQNNNFES 

       430        440        450        460        470        480 
TSKPKKRSSS PIPPLCRAGN TISEESESPD YPRYSTTSLK GARPHASLNH KTHHLKGRSS 

       490        500        510        520        530        540 
ARAKRRMTLA RMNVSMKQSI SGIGRRARKV IPTIRVRDVN LIDKYSRVVF PVCFIVFNLF 

       550 
YWSYYMMVPS

« Hide

References

« Hide 'large scale' references
[1]"Study of the nematode putative GABA type-A receptor subunits: evidence for modulation by ivermectin."
Feng X.-P., Hayashi J., Beech R.N., Prichard R.K.
J. Neurochem. 83:870-878(2002) [PubMed: 12421359] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
[2]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF498370 mRNA. Translation: AAN65376.1.
Z93397 Genomic DNA. Translation: CAB07719.3.
PIRT27614.
RefSeqNP_499661.2. NM_067260.2.
UniGeneCel.9592.

3D structure databases

HSSPHSSP built from PDB template 1VRY based on UniProtKB P23415.
ProteinModelPortalO18276.
SMRO18276. Positions 54-349.
ModBaseSearch...

Proteomic databases

PRIDEO18276.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaZC482.1; ZC482.1; ZC482.1.
GeneID176691.
KEGGcel:ZC482.1.
NMPDRfig|6239.3.peg.11918.
UCSCZC482.1. c. elegans.

Organism-specific databases

CTD176691.
WormBaseZC482.1; CE33742; WBGene00001512; gab-1.

Phylogenomic databases

eggNOGmeNOG05726.
GeneTreeEMGT00050000005201.
HOGENOMHBG506497.
InParanoidO18276.
OMAHEVTERN.
PhylomeDBO18276.

Gene expression databases

ArrayExpressO18276.

Family and domain databases

InterProIPR006028. GABAA_rcpt.
IPR002289. GABAAb_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
Gene3DG3DSA:2.70.170.10. Neur_chan_lig_bd. 1 hit.
KOK05181.
PANTHERPTHR18945. Neur_channel. 1 hit.
PfamPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSPR01160. GABAARBETA.
PR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMSSF90112. Neu_channel_TM. 1 hit.
SSF63712. Neur_chan_LBD. 1 hit.
TIGRFAMsTIGR00860. LIC. 1 hit.
PROSITEPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio893616.

Entry information

Entry nameGBRB_CAEEL
AccessionPrimary (citable) accession number: O18276
Secondary accession number(s): Q8ITG2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 1, 2003
Last modified: November 16, 2011
This is version 80 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormPep

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents