Reviewed, UniProtKB/Swiss-Prot O18229 (6PGL_CAEEL)

Names and origin

Protein names

Recommended name:
    Putative 6-phosphogluconolactonase
      Short name=6PGL
    EC=3.1.1.31

Gene names

ORF Names:

Y57G11C.3

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	269 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate By similarity.
Catalytic activity	6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.
Sequence similarities	Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pentose-phosphate shunt Inferred from electronic annotation. Source: InterPro
Molecular function	6-phosphogluconolactonase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform a (identifier: O18229-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform b (identifier: O18229-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 269	269	Putative 6-phosphogluconolactonase		PRO_0000090080
Natural variations
	Alternative sequence	1 – 12	12	Missing in isoform b.		VSP_020096

Sequences

	Sequence		Length	Mass (Da)
	Isoform a [UniParc]. Last modified July 11, 2001. Version 2. Checksum: 8E79075016E5071A	FASTA	269	30,414
	10 20 30 40 50 60 MCLVNEFVSN SNMKPALNVS GDEKELILQL RRYLEEKLTY LLDQNGTVSI GVSGGSMPRV 70 80 90 100 110 120 FSKAILSLPQ EQLNWKRIRI FMVDERNVDL DSEESNQGEY LRLFPNELRD VFVPMQIFKD 130 140 150 160 170 180 PCLTAQHYEI SLRKYLLPEQ LNNTARFDIL FLGVGPDGHT ASIFPGKERL EKITELNWVS 190 200 210 220 230 240 VITDSPKPPP SRITLTLQTL QHAKNVAFII CGKQKAEIVR GICDRDQKYP AAQARPFNDK 250 260 LTLFLDEDAA TGVPDRDSSD SDSPPPFDG
	Isoform b. Checksum: 40A593793C9F5BA1	FASTA	257	29,075
	10 20 30 40 50 60 MKPALNVSGD EKELILQLRR YLEEKLTYLL DQNGTVSIGV SGGSMPRVFS KAILSLPQEQ 70 80 90 100 110 120 LNWKRIRIFM VDERNVDLDS EESNQGEYLR LFPNELRDVF VPMQIFKDPC LTAQHYEISL 130 140 150 160 170 180 RKYLLPEQLN NTARFDILFL GVGPDGHTAS IFPGKERLEK ITELNWVSVI TDSPKPPPSR 190 200 210 220 230 240 ITLTLQTLQH AKNVAFIICG KQKAEIVRGI CDRDQKYPAA QARPFNDKLT LFLDEDAATG 250 VPDRDSSDSD SPPPFDG

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z99281 Genomic DNA. Translation: CAB16505.2. Z99281 Genomic DNA. Translation: CAJ76962.1.
PIR	F88904. T27244.
RefSeq	NP_001041049.1. NP_001041050.1.
UniGene	Cel.11880
3D structure databases
SMR	O18229. Positions 11-254.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-26505N.
IntAct	O18229. 1 interaction.
STRING	O18229.
Genome annotation databases
Ensembl	Y57G11C.3a; Y57G11C.3a; Y57G11C.3; Caenorhabditis elegans. [Genome view]
GeneID	178398.
KEGG	cel:Y57G11C.3.
NMPDR	fig|6239.3.peg.15970.
UCSC	Y57G11C.3a. c. elegans.
Organism-specific databases
CTD	178398.
WormBase	WBGene00013301. Y57G11C.3.
WormPep	Y57G11C.3a. CE24473. [WorfDB] Y57G11C.3b. CE14930. [WorfDB]
Phylogenomic databases
eggNOG	meNOG15438.
HOGENOM	HBG725991.
InParanoid	O18229.
OMA	FRMETEN.
PhylomeDB	O18229.
Enzyme and pathway databases
BRENDA	3.1.1.31. 672.
Gene expression databases
ArrayExpress	O18229.
Family and domain databases
InterPro	IPR005900. 6-phosphogluconolactonase. IPR006148. Glc/Gal-6P_isomerase. [Graphical view]
PANTHER	PTHR11054. Phosphogluconlac. 1 hit.
Pfam	PF01182. Glucosamine_iso. 1 hit. [Graphical view]
TIGRFAMs	TIGR01198. pgl. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	900966.

Entry information

Entry name

6PGL_CAEEL

Accession

Primary (citable) accession number: O18229
Secondary accession number(s): Q2EEL9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	July 11, 2001
Last modified:	February 9, 2010
This is version 66 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project