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O18229

- 6PGL_CAEEL

UniProt

O18229 - 6PGL_CAEEL

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Protein

Putative 6-phosphogluconolactonase

Gene

Y57G11C.3

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.By similarity

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

Pathwayi

GO - Molecular functioni

  1. 6-phosphogluconolactonase activity Source: UniProtKB-EC

GO - Biological processi

  1. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

ReactomeiREACT_261919. Pentose phosphate pathway (hexose monophosphate shunt).
UniPathwayiUPA00115; UER00409.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 6-phosphogluconolactonase (EC:3.1.1.31)
Short name:
6PGL
Gene namesi
ORF Names:Y57G11C.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome IV

Organism-specific databases

WormBaseiY57G11C.3a; CE24473; WBGene00013301.
Y57G11C.3b; CE14930; WBGene00013301.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: WormBase
  2. sarcomere Source: WormBase
  3. striated muscle dense body Source: WormBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Putative 6-phosphogluconolactonasePRO_0000090080Add
BLAST

Proteomic databases

PaxDbiO18229.

Interactioni

Protein-protein interaction databases

BioGridi43481. 1 interaction.
DIPiDIP-26505N.
MINTiMINT-1106673.
STRINGi6239.Y57G11C.3a.

Structurei

3D structure databases

ProteinModelPortaliO18229.
SMRiO18229. Positions 12-254.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0363.
GeneTreeiENSGT00550000075110.
HOGENOMiHOG000256285.
InParanoidiO18229.
KOiK01057.
OMAiENIYAID.
OrthoDBiEOG7RZ5QV.
PhylomeDBiO18229.

Family and domain databases

InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform a (identifier: O18229-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCLVNEFVSN SNMKPALNVS GDEKELILQL RRYLEEKLTY LLDQNGTVSI
60 70 80 90 100
GVSGGSMPRV FSKAILSLPQ EQLNWKRIRI FMVDERNVDL DSEESNQGEY
110 120 130 140 150
LRLFPNELRD VFVPMQIFKD PCLTAQHYEI SLRKYLLPEQ LNNTARFDIL
160 170 180 190 200
FLGVGPDGHT ASIFPGKERL EKITELNWVS VITDSPKPPP SRITLTLQTL
210 220 230 240 250
QHAKNVAFII CGKQKAEIVR GICDRDQKYP AAQARPFNDK LTLFLDEDAA
260
TGVPDRDSSD SDSPPPFDG

Note: No experimental confirmation available.

Length:269
Mass (Da):30,414
Last modified:July 11, 2001 - v2
Checksum:i8E79075016E5071A
GO
Isoform b (identifier: O18229-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: Missing.

Note: No experimental confirmation available.

Show »
Length:257
Mass (Da):29,075
Checksum:i40A593793C9F5BA1
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1212Missing in isoform b. CuratedVSP_020096Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z99281 Genomic DNA. Translation: CAB16505.2.
Z99281 Genomic DNA. Translation: CAJ76962.1.
PIRiF88904.
T27244.
RefSeqiNP_001041049.1. NM_001047584.3. [O18229-1]
NP_001041050.1. NM_001047585.1. [O18229-2]
UniGeneiCel.11880.

Genome annotation databases

EnsemblMetazoaiY57G11C.3a; Y57G11C.3a; WBGene00013301. [O18229-1]
GeneIDi178398.
KEGGicel:CELE_Y57G11C.3.
UCSCiY57G11C.3a. c. elegans. [O18229-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z99281 Genomic DNA. Translation: CAB16505.2 .
Z99281 Genomic DNA. Translation: CAJ76962.1 .
PIRi F88904.
T27244.
RefSeqi NP_001041049.1. NM_001047584.3. [O18229-1 ]
NP_001041050.1. NM_001047585.1. [O18229-2 ]
UniGenei Cel.11880.

3D structure databases

ProteinModelPortali O18229.
SMRi O18229. Positions 12-254.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 43481. 1 interaction.
DIPi DIP-26505N.
MINTi MINT-1106673.
STRINGi 6239.Y57G11C.3a.

Proteomic databases

PaxDbi O18229.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai Y57G11C.3a ; Y57G11C.3a ; WBGene00013301 . [O18229-1 ]
GeneIDi 178398.
KEGGi cel:CELE_Y57G11C.3.
UCSCi Y57G11C.3a. c. elegans. [O18229-1 ]

Organism-specific databases

CTDi 178398.
WormBasei Y57G11C.3a ; CE24473 ; WBGene00013301 .
Y57G11C.3b ; CE14930 ; WBGene00013301 .

Phylogenomic databases

eggNOGi COG0363.
GeneTreei ENSGT00550000075110.
HOGENOMi HOG000256285.
InParanoidi O18229.
KOi K01057.
OMAi ENIYAID.
OrthoDBi EOG7RZ5QV.
PhylomeDBi O18229.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00409 .
Reactomei REACT_261919. Pentose phosphate pathway (hexose monophosphate shunt).

Miscellaneous databases

NextBioi 900966.
PROi O18229.

Family and domain databases

InterProi IPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view ]
Pfami PF01182. Glucosamine_iso. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01198. pgl. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.

Entry informationi

Entry namei6PGL_CAEEL
AccessioniPrimary (citable) accession number: O18229
Secondary accession number(s): Q2EEL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 11, 2001
Last modified: November 26, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3