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Protein

Putative 6-phosphogluconolactonase

Gene

Y57G11C.3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.By similarity

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

Pathwayi

GO - Molecular functioni

  1. 6-phosphogluconolactonase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

ReactomeiREACT_302484. Pentose phosphate pathway (hexose monophosphate shunt).
UniPathwayiUPA00115; UER00409.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 6-phosphogluconolactonase (EC:3.1.1.31)
Short name:
6PGL
Gene namesi
ORF Names:Y57G11C.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiY57G11C.3a; CE24473; WBGene00013301.
Y57G11C.3b; CE14930; WBGene00013301.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: WormBase
  2. sarcomere Source: WormBase
  3. striated muscle dense body Source: WormBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Putative 6-phosphogluconolactonasePRO_0000090080Add
BLAST

Proteomic databases

PaxDbiO18229.

Interactioni

Protein-protein interaction databases

BioGridi43481. 1 interaction.
DIPiDIP-26505N.
MINTiMINT-1106673.
STRINGi6239.Y57G11C.3a.

Structurei

3D structure databases

ProteinModelPortaliO18229.
SMRiO18229. Positions 12-254.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0363.
GeneTreeiENSGT00550000075110.
HOGENOMiHOG000256285.
InParanoidiO18229.
KOiK01057.
OMAiMEINWEN.
OrthoDBiEOG7RZ5QV.
PhylomeDBiO18229.

Family and domain databases

InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: O18229-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCLVNEFVSN SNMKPALNVS GDEKELILQL RRYLEEKLTY LLDQNGTVSI
60 70 80 90 100
GVSGGSMPRV FSKAILSLPQ EQLNWKRIRI FMVDERNVDL DSEESNQGEY
110 120 130 140 150
LRLFPNELRD VFVPMQIFKD PCLTAQHYEI SLRKYLLPEQ LNNTARFDIL
160 170 180 190 200
FLGVGPDGHT ASIFPGKERL EKITELNWVS VITDSPKPPP SRITLTLQTL
210 220 230 240 250
QHAKNVAFII CGKQKAEIVR GICDRDQKYP AAQARPFNDK LTLFLDEDAA
260
TGVPDRDSSD SDSPPPFDG

Note: No experimental confirmation available.

Length:269
Mass (Da):30,414
Last modified:July 11, 2001 - v2
Checksum:i8E79075016E5071A
GO
Isoform b (identifier: O18229-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: Missing.

Note: No experimental confirmation available.

Show »
Length:257
Mass (Da):29,075
Checksum:i40A593793C9F5BA1
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1212Missing in isoform b. CuratedVSP_020096Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z99281 Genomic DNA. Translation: CAB16505.2.
Z99281 Genomic DNA. Translation: CAJ76962.1.
PIRiF88904.
T27244.
RefSeqiNP_001041049.1. NM_001047584.3. [O18229-1]
NP_001041050.1. NM_001047585.1. [O18229-2]
UniGeneiCel.11880.

Genome annotation databases

EnsemblMetazoaiY57G11C.3a; Y57G11C.3a; WBGene00013301. [O18229-1]
GeneIDi178398.
KEGGicel:CELE_Y57G11C.3.
UCSCiY57G11C.3a. c. elegans. [O18229-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z99281 Genomic DNA. Translation: CAB16505.2.
Z99281 Genomic DNA. Translation: CAJ76962.1.
PIRiF88904.
T27244.
RefSeqiNP_001041049.1. NM_001047584.3. [O18229-1]
NP_001041050.1. NM_001047585.1. [O18229-2]
UniGeneiCel.11880.

3D structure databases

ProteinModelPortaliO18229.
SMRiO18229. Positions 12-254.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi43481. 1 interaction.
DIPiDIP-26505N.
MINTiMINT-1106673.
STRINGi6239.Y57G11C.3a.

Proteomic databases

PaxDbiO18229.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY57G11C.3a; Y57G11C.3a; WBGene00013301. [O18229-1]
GeneIDi178398.
KEGGicel:CELE_Y57G11C.3.
UCSCiY57G11C.3a. c. elegans. [O18229-1]

Organism-specific databases

CTDi178398.
WormBaseiY57G11C.3a; CE24473; WBGene00013301.
Y57G11C.3b; CE14930; WBGene00013301.

Phylogenomic databases

eggNOGiCOG0363.
GeneTreeiENSGT00550000075110.
HOGENOMiHOG000256285.
InParanoidiO18229.
KOiK01057.
OMAiMEINWEN.
OrthoDBiEOG7RZ5QV.
PhylomeDBiO18229.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00409.
ReactomeiREACT_302484. Pentose phosphate pathway (hexose monophosphate shunt).

Miscellaneous databases

NextBioi900966.
PROiO18229.

Family and domain databases

InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.

Entry informationi

Entry namei6PGL_CAEEL
AccessioniPrimary (citable) accession number: O18229
Secondary accession number(s): Q2EEL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 11, 2001
Last modified: April 1, 2015
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.