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Protein

Putative 6-phosphogluconolactonase

Gene

Y57G11C.3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.By similarity

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (gspd-1)
  2. Putative 6-phosphogluconolactonase (Y57G11C.3)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (T25B9.9)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

ReactomeiR-CEL-71336. Pentose phosphate pathway (hexose monophosphate shunt).
UniPathwayiUPA00115; UER00409.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 6-phosphogluconolactonase (EC:3.1.1.31)
Short name:
6PGL
Gene namesi
ORF Names:Y57G11C.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiY57G11C.3a; CE24473; WBGene00013301.
Y57G11C.3b; CE14930; WBGene00013301.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000900801 – 269Putative 6-phosphogluconolactonaseAdd BLAST269

Proteomic databases

EPDiO18229.
PaxDbiO18229.
PeptideAtlasiO18229.
PRIDEiO18229.

Expressioni

Gene expression databases

BgeeiWBGene00013301.

Interactioni

Protein-protein interaction databases

BioGridi43481. 1 interactor.
DIPiDIP-26505N.
IntActiO18229. 1 interactor.
MINTiMINT-1106673.
STRINGi6239.Y57G11C.3a.

Structurei

3D structure databases

ProteinModelPortaliO18229.
SMRiO18229.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3147. Eukaryota.
COG0363. LUCA.
GeneTreeiENSGT00550000075110.
HOGENOMiHOG000256285.
InParanoidiO18229.
KOiK01057.
OMAiKQPHLAI.
OrthoDBiEOG091G0NKD.
PhylomeDBiO18229.

Family and domain databases

CDDicd01400. 6PGL. 1 hit.
InterProiView protein in InterPro
IPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
PfamiView protein in Pfam
PF01182. Glucosamine_iso. 1 hit.
TIGRFAMsiTIGR01198. pgl. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: O18229-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCLVNEFVSN SNMKPALNVS GDEKELILQL RRYLEEKLTY LLDQNGTVSI
60 70 80 90 100
GVSGGSMPRV FSKAILSLPQ EQLNWKRIRI FMVDERNVDL DSEESNQGEY
110 120 130 140 150
LRLFPNELRD VFVPMQIFKD PCLTAQHYEI SLRKYLLPEQ LNNTARFDIL
160 170 180 190 200
FLGVGPDGHT ASIFPGKERL EKITELNWVS VITDSPKPPP SRITLTLQTL
210 220 230 240 250
QHAKNVAFII CGKQKAEIVR GICDRDQKYP AAQARPFNDK LTLFLDEDAA
260
TGVPDRDSSD SDSPPPFDG
Note: No experimental confirmation available.
Length:269
Mass (Da):30,414
Last modified:July 11, 2001 - v2
Checksum:i8E79075016E5071A
GO
Isoform b (identifier: O18229-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: Missing.

Note: No experimental confirmation available.
Show »
Length:257
Mass (Da):29,075
Checksum:i40A593793C9F5BA1
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0200961 – 12Missing in isoform b. CuratedAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z99281 Genomic DNA. Translation: CAB16505.2.
Z99281 Genomic DNA. Translation: CAJ76962.1.
PIRiF88904.
T27244.
RefSeqiNP_001041049.1. NM_001047584.3. [O18229-1]
NP_001041050.1. NM_001047585.1. [O18229-2]
UniGeneiCel.11880.

Genome annotation databases

EnsemblMetazoaiY57G11C.3a; Y57G11C.3a; WBGene00013301. [O18229-1]
GeneIDi178398.
KEGGicel:CELE_Y57G11C.3.
UCSCiY57G11C.3a. c. elegans. [O18229-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry namei6PGL_CAEEL
AccessioniPrimary (citable) accession number: O18229
Secondary accession number(s): Q2EEL9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 11, 2001
Last modified: September 27, 2017
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families