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O18229

- 6PGL_CAEEL

UniProt

O18229 - 6PGL_CAEEL

Protein

Putative 6-phosphogluconolactonase

Gene

Y57G11C.3

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (11 Jul 2001)
      Previous versions | rss
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    Functioni

    Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.By similarity

    Catalytic activityi

    6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

    Pathwayi

    GO - Molecular functioni

    1. 6-phosphogluconolactonase activity Source: UniProtKB-EC

    GO - Biological processi

    1. pentose-phosphate shunt Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    UniPathwayiUPA00115; UER00409.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative 6-phosphogluconolactonase (EC:3.1.1.31)
    Short name:
    6PGL
    Gene namesi
    ORF Names:Y57G11C.3
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome IV

    Organism-specific databases

    WormBaseiY57G11C.3a; CE24473; WBGene00013301.
    Y57G11C.3b; CE14930; WBGene00013301.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: WormBase
    2. sarcomere Source: WormBase
    3. striated muscle dense body Source: WormBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 269269Putative 6-phosphogluconolactonasePRO_0000090080Add
    BLAST

    Proteomic databases

    PaxDbiO18229.

    Interactioni

    Protein-protein interaction databases

    BioGridi43481. 1 interaction.
    DIPiDIP-26505N.
    MINTiMINT-1106673.
    STRINGi6239.Y57G11C.3a.

    Structurei

    3D structure databases

    ProteinModelPortaliO18229.
    SMRiO18229. Positions 42-254.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0363.
    GeneTreeiENSGT00550000075110.
    HOGENOMiHOG000256285.
    InParanoidiO18229.
    KOiK01057.
    OMAiENIYAID.
    OrthoDBiEOG7RZ5QV.
    PhylomeDBiO18229.

    Family and domain databases

    InterProiIPR005900. 6-phosphogluconolactonase_DevB.
    IPR006148. Glc/Gal-6P_isomerase.
    [Graphical view]
    PfamiPF01182. Glucosamine_iso. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01198. pgl. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform a (identifier: O18229-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MCLVNEFVSN SNMKPALNVS GDEKELILQL RRYLEEKLTY LLDQNGTVSI    50
    GVSGGSMPRV FSKAILSLPQ EQLNWKRIRI FMVDERNVDL DSEESNQGEY 100
    LRLFPNELRD VFVPMQIFKD PCLTAQHYEI SLRKYLLPEQ LNNTARFDIL 150
    FLGVGPDGHT ASIFPGKERL EKITELNWVS VITDSPKPPP SRITLTLQTL 200
    QHAKNVAFII CGKQKAEIVR GICDRDQKYP AAQARPFNDK LTLFLDEDAA 250
    TGVPDRDSSD SDSPPPFDG 269

    Note: No experimental confirmation available.

    Length:269
    Mass (Da):30,414
    Last modified:July 11, 2001 - v2
    Checksum:i8E79075016E5071A
    GO
    Isoform b (identifier: O18229-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-12: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:257
    Mass (Da):29,075
    Checksum:i40A593793C9F5BA1
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1212Missing in isoform b. CuratedVSP_020096Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z99281 Genomic DNA. Translation: CAB16505.2.
    Z99281 Genomic DNA. Translation: CAJ76962.1.
    PIRiF88904.
    T27244.
    RefSeqiNP_001041049.1. NM_001047584.3. [O18229-1]
    NP_001041050.1. NM_001047585.1. [O18229-2]
    UniGeneiCel.11880.

    Genome annotation databases

    EnsemblMetazoaiY57G11C.3a; Y57G11C.3a; WBGene00013301. [O18229-1]
    GeneIDi178398.
    KEGGicel:CELE_Y57G11C.3.
    UCSCiY57G11C.3a. c. elegans. [O18229-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z99281 Genomic DNA. Translation: CAB16505.2 .
    Z99281 Genomic DNA. Translation: CAJ76962.1 .
    PIRi F88904.
    T27244.
    RefSeqi NP_001041049.1. NM_001047584.3. [O18229-1 ]
    NP_001041050.1. NM_001047585.1. [O18229-2 ]
    UniGenei Cel.11880.

    3D structure databases

    ProteinModelPortali O18229.
    SMRi O18229. Positions 42-254.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 43481. 1 interaction.
    DIPi DIP-26505N.
    MINTi MINT-1106673.
    STRINGi 6239.Y57G11C.3a.

    Proteomic databases

    PaxDbi O18229.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai Y57G11C.3a ; Y57G11C.3a ; WBGene00013301 . [O18229-1 ]
    GeneIDi 178398.
    KEGGi cel:CELE_Y57G11C.3.
    UCSCi Y57G11C.3a. c. elegans. [O18229-1 ]

    Organism-specific databases

    CTDi 178398.
    WormBasei Y57G11C.3a ; CE24473 ; WBGene00013301 .
    Y57G11C.3b ; CE14930 ; WBGene00013301 .

    Phylogenomic databases

    eggNOGi COG0363.
    GeneTreei ENSGT00550000075110.
    HOGENOMi HOG000256285.
    InParanoidi O18229.
    KOi K01057.
    OMAi ENIYAID.
    OrthoDBi EOG7RZ5QV.
    PhylomeDBi O18229.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00409 .

    Miscellaneous databases

    NextBioi 900966.
    PROi O18229.

    Family and domain databases

    InterProi IPR005900. 6-phosphogluconolactonase_DevB.
    IPR006148. Glc/Gal-6P_isomerase.
    [Graphical view ]
    Pfami PF01182. Glucosamine_iso. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01198. pgl. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
      Strain: Bristol N2.

    Entry informationi

    Entry namei6PGL_CAEEL
    AccessioniPrimary (citable) accession number: O18229
    Secondary accession number(s): Q2EEL9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: July 11, 2001
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3