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Protein
Submitted name:

Ligand-Gated ion Channel

Gene

lgc-7

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotation

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-CEL-975298. Ligand-gated ion channel transport.

Names & Taxonomyi

Protein namesi
Submitted name:
Ligand-Gated ion ChannelImported
Gene namesi
Name:lgc-7Imported
ORF Names:CELE_Y57G11C.2Imported, Y57G11C.2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiY57G11C.2; CE36675; WBGene00013300; lgc-7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei240 – 26223HelicalSequence analysisAdd
BLAST
Transmembranei274 – 29522HelicalSequence analysisAdd
BLAST
Transmembranei307 – 32822HelicalSequence analysisAdd
BLAST
Transmembranei419 – 43719HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 439415Sequence analysisPRO_5004157144Add
BLAST

Proteomic databases

PaxDbiO18228.

Expressioni

Gene expression databases

BgeeiWBGene00013300.

Interactioni

Protein-protein interaction databases

DIPiDIP-27110N.
MINTiMINT-1120043.

Structurei

3D structure databases

ProteinModelPortaliO18228.
SMRiO18228. Positions 29-365.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 238210Neur_chan_LBDInterPro annotationAdd
BLAST
Domaini245 – 361117Neur_chan_membInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00790000122957.
HOGENOMiHOG000022070.
InParanoidiO18228.
OMAiNLCDMNV.
OrthoDBiEOG091G07VZ.
PhylomeDBiO18228.

Family and domain databases

Gene3Di1.20.120.370. 1 hit.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O18228-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFYDFKFVF YLAISWCNLL EVDGITVAEQ LKDVLMEGYD SSIRPVNNER
60 70 80 90 100
DILIINISMN TMSVLTLDPA EETINFSSEF ILQWKDEFLF WNKSDYNITW
110 120 130 140 150
LKLKESFLWT PDTTVSTSID TNYLIDASER YVSVKHDGTV RQSIYAVFTN
160 170 180 190 200
LCDMNVDKFP YDQQTCMIKM GPWSYTTQEV TCIVGRDIAP NDTDFGDFHG
210 220 230 240 250
NSEWDFEGIV SSVGETEDPD VNFTFSEVHF ALTVKRRPQF YVWVLLIPTY
260 270 280 290 300
IITVVCIFGL FTPTANHGLR EERVNLGITT LLSSAVILQI VANAMPKTSE
310 320 330 340 350
LPLLGNFILA EIFVVAIGVL FAVLVLTLHQ RAHTREWRPP AWMLWILRMT
360 370 380 390 400
GSSKFLSRNI TKIRHKSSTA ERIHYTGEGA YLFKNLDESL QSVREYIQEE
410 420 430
DRDYFRELTY VKFFDRLDFL LLFIFQVGNA LVTLFLVKQ
Length:439
Mass (Da):50,822
Last modified:September 13, 2004 - v2
Checksum:iDE22BDC22959E81E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CAB16504.2.
PIRiT27216.
RefSeqiNP_502777.2. NM_070376.2.
UniGeneiCel.11881.

Genome annotation databases

EnsemblMetazoaiY57G11C.2; Y57G11C.2; WBGene00013300.
GeneIDi190370.
KEGGicel:CELE_Y57G11C.2.
UCSCiY57G11C.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CAB16504.2.
PIRiT27216.
RefSeqiNP_502777.2. NM_070376.2.
UniGeneiCel.11881.

3D structure databases

ProteinModelPortaliO18228.
SMRiO18228. Positions 29-365.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-27110N.
MINTiMINT-1120043.

Proteomic databases

PaxDbiO18228.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY57G11C.2; Y57G11C.2; WBGene00013300.
GeneIDi190370.
KEGGicel:CELE_Y57G11C.2.
UCSCiY57G11C.2. c. elegans.

Organism-specific databases

CTDi190370.
WormBaseiY57G11C.2; CE36675; WBGene00013300; lgc-7.

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00790000122957.
HOGENOMiHOG000022070.
InParanoidiO18228.
OMAiNLCDMNV.
OrthoDBiEOG091G07VZ.
PhylomeDBiO18228.

Enzyme and pathway databases

ReactomeiR-CEL-975298. Ligand-gated ion channel transport.

Gene expression databases

BgeeiWBGene00013300.

Family and domain databases

Gene3Di1.20.120.370. 1 hit.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO18228_CAEEL
AccessioniPrimary (citable) accession number: O18228
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: September 13, 2004
Last modified: September 7, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.