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Protein

Phospholipid-transporting ATPase

Gene

tat-3

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

  • sterol metabolic process Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, MagnesiumSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.3.1. 1045.
ReactomeiR-CEL-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid-transporting ATPaseUniRule annotation (EC:3.6.3.1UniRule annotation)
Gene namesi
Name:tat-3Imported
ORF Names:CELE_W09D10.2Imported, W09D10.2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiW09D10.2; CE43310; WBGene00012360; tat-3.

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei131 – 14818HelicalUniRule annotationAdd
BLAST
Transmembranei363 – 38523HelicalUniRule annotationAdd
BLAST
Transmembranei426 – 44823HelicalUniRule annotationAdd
BLAST
Transmembranei1139 – 115921HelicalUniRule annotationAdd
BLAST
Transmembranei1171 – 119121HelicalUniRule annotationAdd
BLAST
Transmembranei1221 – 124323HelicalUniRule annotationAdd
BLAST
Transmembranei1255 – 127319HelicalUniRule annotationAdd
BLAST
Transmembranei1285 – 130824HelicalUniRule annotationAdd
BLAST
Transmembranei1328 – 134619HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiO18182.

Interactioni

Protein-protein interaction databases

STRINGi6239.W09D10.2.

Structurei

3D structure databases

ProteinModelPortaliO18182.
SMRiO18182. Positions 814-1183.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini97 – 15256PhoLip_ATPase_NInterPro annotationAdd
BLAST
Domaini162 – 448287E1-E2_ATPaseInterPro annotationAdd
BLAST
Domaini1107 – 1356250PhoLip_ATPase_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0206. Eukaryota.
COG0474. LUCA.
GeneTreeiENSGT00770000120474.
HOGENOMiHOG000202528.
InParanoidiO18182.
OMAiFAMARFR.
OrthoDBiEOG76471S.
PhylomeDBiO18182.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 3 hits.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 2 hits.
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01652. ATPase-Plipid. 2 hits.
TIGR01494. ATPase_P-type. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O18182-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKKSVDVEA STSNSSSALY DTTVTKGHHR RTSSLWVPPT RPIFSSPTQV
60 70 80 90 100
IKEKAENGGR ILKTHPVTRW LFPTQPMLPQ QRLVVPNNQK EPPPRYEQPN
110 120 130 140 150
RKYCGNRIST TKYSVLTFIP KNLFEQLHRA ANLYFIFIVI LNMIIGAFGK
160 170 180 190 200
YISVLPIAFV LGITAIKDAF EDYRRYKSDQ KINHSTCRVW DASQQRYRKL
210 220 230 240 250
EWQNILVGDF VHLSHDEIIP ADILLLRSSD VNGVCYVETC NLDGESNLKQ
260 270 280 290 300
RQAIRSMGKY HNANVPLEYS PAEFNYRIAC EQPTTDVYKF EGRLEAIEGG
310 320 330 340 350
PPLAREFTIL AKENVLLRGC VVKNTDFVEG IVLYAGKDTK AMLNNNGPRY
360 370 380 390 400
KRSSLEKMTN VDILWSVCTL LALCVIGAVL SGVWLRTFST PYIVPFLVFI
410 420 430 440 450
HPNSSYHNNN DSQYKYSPSY ESWFSFWSYI IVLQVMIPIS LYVSIEFIKI
460 470 480 490 500
FQVWFMSQDR NMYYDKVDKR LQCRALNITE ELGQIQYVMS DKTGTLTENQ
510 520 530 540 550
MVFRRCSVNG NDYGGRPVVD AVDSSLELVA STLRSDQPTE KKLQMAALAE
560 570 580 590 600
AAAKTRRLRP SRDPALESQL ASSVLKLGAD IDDPVFAFFL TMAICNTVVV
610 620 630 640 650
NAKPHEDLMD PDGDIVNSRF APEEVSPRRG SSLEDGFKYL ADVEEESPAS
660 670 680 690 700
TQASTPVMIT EENDGFEEIE LIEFPEVKTD ETQMTEKEET ISAEVAAKKS
710 720 730 740 750
GSDEKDNNYN GERKEGKGFG ILHRPSILSV PFAKLKGMKS PFRRSVDKRS
760 770 780 790 800
SSSTETAVAP PLHSFYDSES PDELALVEAA REYGIRLLRR RFDDVIVYLR
810 820 830 840 850
HSTSSVKYKV LHTLPFDADR KRMSVIIRES SGLKRIIVLT KGADATVIPV
860 870 880 890 900
LSEAFSTSAR GEEVIFKSQE HLTQYAKEGL RTLCLSMKIW TEEEYQGWKE
910 920 930 940 950
KHEEAELDMM DKETMLAEST LRAEQDLELL GVTAIEDRLQ DGVPECIHSL
960 970 980 990 1000
REAGIRVWVL TGDKIETAVN IAYSSRLFSP SMDLLNIGAN GVRAVSDLLT
1010 1020 1030 1040 1050
EHLKRIARAY EVSADAADSF GLVLNASTMS YCLDPHNLER FVKLLRGCRS
1060 1070 1080 1090 1100
VLCCRATPLQ KAQLVNLAKN HLKGKVLAIG DGANDVSMIQ GADVGIGLSG
1110 1120 1130 1140 1150
QEGMQAVMSS DFAMARFRFL SNLLLVHGHW NYYRLAQTIL YFFYKNAMLV
1160 1170 1180 1190 1200
FVIFWYQIFN GFSAQVPIDP VYLMVYNLIF TSVPPLLFGC LDQDASAELL
1210 1220 1230 1240 1250
LDCPRLYEQG RLGKRYRWYS FWINMLDAVW QSLVVFFICY FTYRGSNVDM
1260 1270 1280 1290 1300
WTFGHLLVTQ LIIVNTFHLA LFVQYWTWPM FWSMFLSVLL FFICALLYNG
1310 1320 1330 1340 1350
FVTANWTWTN VKDPPSMVSL KSFSSLEFWM ALIISVVLCL TPRYVLTTVV
1360 1370 1380 1390 1400
NTVSPSTTLR TRLGAEDGFK KKTESRFTAC AVGCLSAPFK CARMCCQKTK
1410
PADVHIEEVH H
Length:1,411
Mass (Da):159,945
Last modified:December 16, 2008 - v3
Checksum:i545C4F858FC225CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA. Translation: CAB07859.3.
RefSeqiNP_499363.3. NM_066962.4.
UniGeneiCel.9919.

Genome annotation databases

EnsemblMetazoaiW09D10.2; W09D10.2; WBGene00012360.
GeneIDi176498.
KEGGicel:CELE_W09D10.2.
UCSCiW09D10.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA. Translation: CAB07859.3.
RefSeqiNP_499363.3. NM_066962.4.
UniGeneiCel.9919.

3D structure databases

ProteinModelPortaliO18182.
SMRiO18182. Positions 814-1183.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.W09D10.2.

Proteomic databases

PaxDbiO18182.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiW09D10.2; W09D10.2; WBGene00012360.
GeneIDi176498.
KEGGicel:CELE_W09D10.2.
UCSCiW09D10.2. c. elegans.

Organism-specific databases

CTDi176498.
WormBaseiW09D10.2; CE43310; WBGene00012360; tat-3.

Phylogenomic databases

eggNOGiKOG0206. Eukaryota.
COG0474. LUCA.
GeneTreeiENSGT00770000120474.
HOGENOMiHOG000202528.
InParanoidiO18182.
OMAiFAMARFR.
OrthoDBiEOG76471S.
PhylomeDBiO18182.

Enzyme and pathway databases

BRENDAi3.6.3.1. 1045.
ReactomeiR-CEL-936837. Ion transport by P-type ATPases.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 3 hits.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 2 hits.
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01652. ATPase-Plipid. 2 hits.
TIGR01494. ATPase_P-type. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiO18182_CAEEL
AccessioniPrimary (citable) accession number: O18182
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: December 16, 2008
Last modified: July 6, 2016
This is version 139 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.