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Protein

UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase

Gene

ogt-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Addition of nucleotide-activated sugars directly onto the polypeptide through O-glycosidic linkage with the hydroxyl of serine or threonine.By similarity

Catalytic activityi

UDP-N-acetyl-alpha-D-glucosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine.By similarity
UDP-N-acetyl-alpha-D-glucosamine + [protein]-L-threonine = UDP + [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine.By similarity

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei612Proton acceptorBy similarity1
Binding sitei954UDPBy similarity1
Binding sitei957UDPBy similarity1
Binding sitei1040UDPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi1010 – 1013UDPBy similarity4
Nucleotide bindingi1016 – 1019UDPBy similarity4
Nucleotide bindingi1034 – 1036UDPBy similarity3

GO - Molecular functioni

  • protein N-acetylglucosaminyltransferase activity Source: WormBase
  • protein serine/threonine phosphatase activity Source: WormBase

GO - Biological processi

  • dauer larval development Source: WormBase
  • energy reserve metabolic process Source: WormBase
  • glycogen metabolic process Source: WormBase
  • lipid storage Source: WormBase
  • protein dephosphorylation Source: WormBase
  • protein O-linked glycosylation Source: WormBase
  • reproduction Source: WormBase

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378

Protein family/group databases

CAZyiGT41 Glycosyltransferase Family 41

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase (EC:2.4.1.255By similarity)
Alternative name(s):
O-GlcNAc
OGT
Gene namesi
Name:ogt-1
ORF Names:K04G7.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiK04G7.3a ; CE25042 ; WBGene00003858 ; ogt-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001917751 – 1151UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferaseAdd BLAST1151

Proteomic databases

EPDiO18158
PaxDbiO18158
PeptideAtlasiO18158
PRIDEiO18158

Expressioni

Gene expression databases

BgeeiWBGene00003858
ExpressionAtlasiO18158 baseline and differential

Interactioni

Protein-protein interaction databases

BioGridi41212, 3 interactors
DIPiDIP-26521N
IntActiO18158, 2 interactors
STRINGi6239.K04G7.3a

Structurei

3D structure databases

ProteinModelPortaliO18158
SMRiO18158
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati125 – 158TPR 1Add BLAST34
Repeati193 – 226TPR 2Add BLAST34
Repeati227 – 260TPR 3Add BLAST34
Repeati261 – 294TPR 4Add BLAST34
Repeati295 – 328TPR 5Add BLAST34
Repeati329 – 362TPR 6Add BLAST34
Repeati363 – 396TPR 7Add BLAST34
Repeati397 – 430TPR 8Add BLAST34
Repeati431 – 464TPR 9Add BLAST34
Repeati465 – 498TPR 10Add BLAST34
Repeati499 – 532TPR 11Add BLAST34
Repeati533 – 566TPR 12Add BLAST34
Repeati567 – 577TPR 13; truncatedAdd BLAST11

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi591 – 607Nuclear localization signalSequence analysisAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi63 – 106Gln-richAdd BLAST44

Domaini

The TPR repeat domain mediates recognition of protein substrates.By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG4626 Eukaryota
COG0457 LUCA
COG3914 LUCA
GeneTreeiENSGT00550000074327
HOGENOMiHOG000003765
InParanoidiO18158
KOiK09667
OMAiPFMDYII
OrthoDBiEOG091G024Y
PhylomeDBiO18158

Family and domain databases

Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR037919 OGT
IPR029489 OGT/SEC/SPY_C
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR001440 TPR_1
IPR019734 TPR_repeat
PANTHERiPTHR44366 PTHR44366, 1 hit
PfamiView protein in Pfam
PF13844 Glyco_transf_41, 1 hit
PF00515 TPR_1, 1 hit
PF13181 TPR_8, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 12 hits
SUPFAMiSSF48452 SSF48452, 4 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 12 hits
PS50293 TPR_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

O18158-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKPNYFQSY NKVIGATGEQ LAPGAVPPHP VLAPSIAPGG VAGVSAANMA
60 70 80 90 100
NIMQTPGFAN LVQQAIRTQL ENQAAQQLAV NQQFQLNGAT AVQQQLLLTP
110 120 130 140 150
QQSLAQPIAL APQPTVVLNG VSETLKKVTE LAHRQFQSGN YVEAEKYCNL
160 170 180 190 200
VFQSDPNNLP TLLLLSAINF QTKNLEKSMQ YSMLAIKVNN QCAEAYSNLG
210 220 230 240 250
NYYKEKGQLQ DALENYKLAV KLKPEFIDAY INLAAALVSG GDLEQAVTAY
260 270 280 290 300
FNALQINPDL YCVRSDLGNL LKAMGRLEEA KVCYLKAIET QPQFAVAWSN
310 320 330 340 350
LGCVFNSQGE IWLAIHHFEK AVTLDPNFLD AYINLGNVLK EARIFDRAVS
360 370 380 390 400
AYLRALNLSG NHAVVHGNLA CVYYEQGLID LAIDTYKKAI DLQPHFPDAY
410 420 430 440 450
CNLANALKEK GSVVEAEQMY MKALELCPTH ADSQNNLANI KREQGKIEDA
460 470 480 490 500
TRLYLKALEI YPEFAAAHSN LASILQQQGK LNDAILHYKE AIRIAPTFAD
510 520 530 540 550
AYSNMGNTLK EMGDSSAAIA CYNRAIQINP AFADAHSNLA SIHKDAGNMA
560 570 580 590 600
EAIQSYSTAL KLKPDFPDAY CNLAHCHQII CDWNDYDKRV RKLVQIVEDQ
610 620 630 640 650
LCKKRLPSVH PHHSMLYPLS HAARIAIAAK HASLCFDKVH VQMLGKTPLI
660 670 680 690 700
HADRFSVQNG QRLRIGYVSS DFGNHPTSHL MQSIPGMHDR SRVEVFCYAL
710 720 730 740 750
SVNDGTNFRS KLMNESEHFV DLSQIPCNGK AAEKIAQDGI HILINMNGYT
760 770 780 790 800
KGARNEIFAL RPAPIQVMWL GYPSTSGATF MDYIITDAVT SPLRLANAFT
810 820 830 840 850
EKLAYMPHTF FIGDHAQMLR HLTDKVVVKD KETTERDSCL IMNTANMDPI
860 870 880 890 900
LAKSEIKEQV LDTEVVSGPN KELVRAEMVL PVLEVPTEPI KQMIMTGQMT
910 920 930 940 950
MNVMEDMNVQ NGLGQSQMHH KAATGEEIPN SVLLTSRAQY QLPDDAIVFC
960 970 980 990 1000
NFNQLYKIDP STLDMWIKIL ENVPKSILWL LRFPYQGEEH IRKYCVERGL
1010 1020 1030 1040 1050
DPSRIVFSNV AAKEEHVRRG QLADVCLDTP LCNGHTTGMD ILWTGTPMVT
1060 1070 1080 1090 1100
MPLESLASRV ATSQLYALGV PELVAKTRQE YVSIAVRLGT DADHLANMRA
1110 1120 1130 1140 1150
KVWMARTSST LFDVKQYCHD MEDLLGQMWK RYESGMPIDH ITNNTETPHG

L
Length:1,151
Mass (Da):128,012
Last modified:October 1, 2002 - v2
Checksum:iD1CE2A19401CC44F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti129T → A in AAB63465 (PubMed:9083068).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77412 mRNA Translation: AAB63465.1
FO080149 Genomic DNA Translation: CCD61614.1
PIRiE88499
RefSeqiNP_001040860.1, NM_001047395.3
UniGeneiCel.16882

Genome annotation databases

EnsemblMetazoaiK04G7.3a.1; K04G7.3a.1; WBGene00003858
K04G7.3a.2; K04G7.3a.2; WBGene00003858
GeneIDi176000
KEGGicel:CELE_K04G7.3
UCSCiK04G7.3a c. elegans

Similar proteinsi

Entry informationi

Entry nameiOGT1_CAEEL
AccessioniPrimary (citable) accession number: O18158
Secondary accession number(s): Q21232
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health