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Protein

Nuclear hormone receptor family member nhr-127

Gene

nhr-127

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Orphan nuclear receptor.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi10 – 86Nuclear receptorPROSITE-ProRule annotationAdd BLAST77
Zinc fingeri13 – 33NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri49 – 69NR C4-typePROSITE-ProRule annotationAdd BLAST21

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear hormone receptor family member nhr-127
Gene namesi
Name:nhr-127
ORF Names:T13F3.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiT13F3.3; CE35617; WBGene00003717; nhr-127.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002237021 – 355Nuclear hormone receptor family member nhr-127Add BLAST355

Proteomic databases

PaxDbiO18087.

Expressioni

Gene expression databases

BgeeiWBGene00003717.

Interactioni

Protein-protein interaction databases

IntActiO18087. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliO18087.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.Curated
Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri13 – 33NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri49 – 69NR C4-typePROSITE-ProRule annotationAdd BLAST21

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00820000127229.
HOGENOMiHOG000020710.
InParanoidiO18087.
OrthoDBiEOG091G1LLF.
PhylomeDBiO18087.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O18087-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKITFSPELS IPCEVCKNQS NGYHFEVLSC GACASFFRRS VVSKIKYQCK
60 70 80 90 100
DGKKRCQIRY LDRHFCRYCR FSKCVKAGMK AEKIQKNRDL DSSPTPTDQN
110 120 130 140 150
NCIPSDVLHD DGILIKDIRG LFKQFNPHNA SEGCSKLEKL TEGLQFIRRN
160 170 180 190 200
QERECIKIID EMDSESLKDV QFKVIGSCAT WLLFSSFFQK LEENEKVVIL
210 220 230 240 250
ERLWHGWTVL EFLSRSLEIF GNKVIDEKIV FISDNTAIRL ITAFENSLKT
260 270 280 290 300
ASPKKSESIK KKLELSFSVI FDELALHFIN WKPTEIEISY MQWQIVWSVA
310 320 330 340 350
EQLLSGNSLE KGEHFTEQLS KDLHEYYVRE LKLENYAFRI EKMMDIVQIV

QNNFY
Length:355
Mass (Da):41,475
Last modified:July 5, 2004 - v2
Checksum:iE985FFF8130E550D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z93389 Genomic DNA. Translation: CAB07671.2.
PIRiT24891.
RefSeqiNP_507104.2. NM_074703.2.
UniGeneiCel.2316.

Genome annotation databases

EnsemblMetazoaiT13F3.3; T13F3.3; WBGene00003717.
GeneIDi188480.
KEGGicel:CELE_T13F3.3.
UCSCiT13F3.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z93389 Genomic DNA. Translation: CAB07671.2.
PIRiT24891.
RefSeqiNP_507104.2. NM_074703.2.
UniGeneiCel.2316.

3D structure databases

ProteinModelPortaliO18087.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO18087. 1 interactor.

Proteomic databases

PaxDbiO18087.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT13F3.3; T13F3.3; WBGene00003717.
GeneIDi188480.
KEGGicel:CELE_T13F3.3.
UCSCiT13F3.3. c. elegans.

Organism-specific databases

CTDi188480.
WormBaseiT13F3.3; CE35617; WBGene00003717; nhr-127.

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00820000127229.
HOGENOMiHOG000020710.
InParanoidiO18087.
OrthoDBiEOG091G1LLF.
PhylomeDBiO18087.

Miscellaneous databases

PROiO18087.

Gene expression databases

BgeeiWBGene00003717.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNH127_CAEEL
AccessioniPrimary (citable) accession number: O18087
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.