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O18037

- CGT1_CAEEL

UniProt

O18037 - CGT1_CAEEL

Protein

Ceramide glucosyltransferase 1

Gene

cgt-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 2 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide.1 Publication

    Catalytic activityi

    UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine.1 Publication

    Pathwayi

    GO - Molecular functioni

    1. ceramide glucosyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. sphingolipid metabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Sphingolipid metabolism

    Enzyme and pathway databases

    ReactomeiREACT_197713. Glycosphingolipid metabolism.
    UniPathwayiUPA00222.

    Protein family/group databases

    CAZyiGT21. Glycosyltransferase Family 21.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ceramide glucosyltransferase 1 (EC:2.4.1.80)
    Gene namesi
    Name:cgt-1
    ORF Names:T06C12.10
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome V

    Organism-specific databases

    WormBaseiT06C12.10; CE31986; WBGene00011517; cgt-1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Reduced brood size.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 466466Ceramide glucosyltransferase 1PRO_0000421281Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.T06C12.10.2.

    Structurei

    3D structure databases

    ProteinModelPortaliO18037.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei70 – 9021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei354 – 37421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei403 – 42321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 2 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1215.
    GeneTreeiENSGT00390000012898.
    HOGENOMiHOG000039663.
    InParanoidiO18037.
    OMAiEILFCAR.
    PhylomeDBiO18037.

    Family and domain databases

    Gene3Di3.90.550.10. 1 hit.
    InterProiIPR025993. Ceramide_glucosylTrfase.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view]
    PfamiPF13506. Glyco_transf_21. 1 hit.
    [Graphical view]
    SUPFAMiSSF53448. SSF53448. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O18037-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEAANEVVNL FASQATTPSS LDAVTTLETV STPTFIFPEV SDSQILQLMP    50
    ATLYSGMNWL RDHLDGFSLL ALSGCIFVSV LYLVHIIAFF YSIYRLHHKV 100
    EPDPTLPGVS VIKPIVGTDK NLYQNLESFF TSQYHSFELL FCFHSEEDEA 150
    IEVVRSLIKK HPNIEAKILF EGEPVGMNPK VNNMMPAYRA ARYPLVLISD 200
    SAIFMRPDGI LDMATTMMSH EKMASVTQIP YCKDRQGFHA AFEQIFFGTS 250
    HARLYLVGNF LGVVCSSGMS SMMKKSALDE CGGMEKFGEY LAEDYFFAKA 300
    LTSRGCKAAI STHPALQNSA SVTVLSFFNR IGRWIKLRIA MMPHLMVVEP 350
    LQDCVTSGLI MAFGLNYLGG YSVYKTFGLH LFYWIVMDFS LMTSMQNGKF 400
    NFTPFLFVFI WLFREFTSPF IFIKAVLAPT IVWRNNKFKL SWGGRIRTSK 450
    NSQKVPEAVS LSKGAV 466
    Length:466
    Mass (Da):52,416
    Last modified:March 1, 2003 - v2
    Checksum:iEBC36C0EF42C5831
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z81116 Genomic DNA. Translation: CAB03296.2.
    PIRiT24561.
    RefSeqiNP_506971.2. NM_074570.4.
    UniGeneiCel.23835.

    Genome annotation databases

    EnsemblMetazoaiT06C12.10; T06C12.10; WBGene00011517.
    GeneIDi188169.
    KEGGicel:CELE_T06C12.10.
    UCSCiT06C12.10.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z81116 Genomic DNA. Translation: CAB03296.2 .
    PIRi T24561.
    RefSeqi NP_506971.2. NM_074570.4.
    UniGenei Cel.23835.

    3D structure databases

    ProteinModelPortali O18037.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.T06C12.10.2.

    Protein family/group databases

    CAZyi GT21. Glycosyltransferase Family 21.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai T06C12.10 ; T06C12.10 ; WBGene00011517 .
    GeneIDi 188169.
    KEGGi cel:CELE_T06C12.10.
    UCSCi T06C12.10.1. c. elegans.

    Organism-specific databases

    CTDi 188169.
    WormBasei T06C12.10 ; CE31986 ; WBGene00011517 ; cgt-1.

    Phylogenomic databases

    eggNOGi COG1215.
    GeneTreei ENSGT00390000012898.
    HOGENOMi HOG000039663.
    InParanoidi O18037.
    OMAi EILFCAR.
    PhylomeDBi O18037.

    Enzyme and pathway databases

    UniPathwayi UPA00222 .
    Reactomei REACT_197713. Glycosphingolipid metabolism.

    Miscellaneous databases

    NextBioi 937850.

    Family and domain databases

    Gene3Di 3.90.550.10. 1 hit.
    InterProi IPR025993. Ceramide_glucosylTrfase.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view ]
    Pfami PF13506. Glyco_transf_21. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53448. SSF53448. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    2. "Ceramide glucosyltransferase of the nematode Caenorhabditis elegans is involved in oocyte formation and in early embryonic cell division."
      Nomura K.H., Murata D., Hayashi Y., Dejima K., Mizuguchi S., Kage-Nakadai E., Gengyo-Ando K., Mitani S., Hirabayashi Y., Ito M., Nomura K.
      Glycobiology 21:834-848(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, CATALYTIC ACTIVITY, PATHWAY, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiCGT1_CAEEL
    AccessioniPrimary (citable) accession number: O18037
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 6, 2013
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 81 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3