Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O18037

- CGT1_CAEEL

UniProt

O18037 - CGT1_CAEEL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Ceramide glucosyltransferase 1

Gene

cgt-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide.1 Publication

Catalytic activityi

UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine.1 Publication

Pathwayi

GO - Molecular functioni

  1. ceramide glucosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. sphingolipid metabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Sphingolipid metabolism

Enzyme and pathway databases

ReactomeiREACT_197713. Glycosphingolipid metabolism.
UniPathwayiUPA00222.

Protein family/group databases

CAZyiGT21. Glycosyltransferase Family 21.

Names & Taxonomyi

Protein namesi
Recommended name:
Ceramide glucosyltransferase 1 (EC:2.4.1.80)
Gene namesi
Name:cgt-1
ORF Names:T06C12.10
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome V

Organism-specific databases

WormBaseiT06C12.10; CE31986; WBGene00011517; cgt-1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Reduced brood size.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 466466Ceramide glucosyltransferase 1PRO_0000421281Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi6239.T06C12.10.2.

Structurei

3D structure databases

ProteinModelPortaliO18037.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei70 – 9021HelicalSequence AnalysisAdd
BLAST
Transmembranei354 – 37421HelicalSequence AnalysisAdd
BLAST
Transmembranei403 – 42321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1215.
GeneTreeiENSGT00390000012898.
HOGENOMiHOG000039663.
InParanoidiO18037.
OMAiEILFCAR.
PhylomeDBiO18037.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR025993. Ceramide_glucosylTrfase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF13506. Glyco_transf_21. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

O18037-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEAANEVVNL FASQATTPSS LDAVTTLETV STPTFIFPEV SDSQILQLMP
60 70 80 90 100
ATLYSGMNWL RDHLDGFSLL ALSGCIFVSV LYLVHIIAFF YSIYRLHHKV
110 120 130 140 150
EPDPTLPGVS VIKPIVGTDK NLYQNLESFF TSQYHSFELL FCFHSEEDEA
160 170 180 190 200
IEVVRSLIKK HPNIEAKILF EGEPVGMNPK VNNMMPAYRA ARYPLVLISD
210 220 230 240 250
SAIFMRPDGI LDMATTMMSH EKMASVTQIP YCKDRQGFHA AFEQIFFGTS
260 270 280 290 300
HARLYLVGNF LGVVCSSGMS SMMKKSALDE CGGMEKFGEY LAEDYFFAKA
310 320 330 340 350
LTSRGCKAAI STHPALQNSA SVTVLSFFNR IGRWIKLRIA MMPHLMVVEP
360 370 380 390 400
LQDCVTSGLI MAFGLNYLGG YSVYKTFGLH LFYWIVMDFS LMTSMQNGKF
410 420 430 440 450
NFTPFLFVFI WLFREFTSPF IFIKAVLAPT IVWRNNKFKL SWGGRIRTSK
460
NSQKVPEAVS LSKGAV
Length:466
Mass (Da):52,416
Last modified:March 1, 2003 - v2
Checksum:iEBC36C0EF42C5831
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z81116 Genomic DNA. Translation: CAB03296.2.
PIRiT24561.
RefSeqiNP_506971.2. NM_074570.4.
UniGeneiCel.23835.

Genome annotation databases

EnsemblMetazoaiT06C12.10; T06C12.10; WBGene00011517.
GeneIDi188169.
KEGGicel:CELE_T06C12.10.
UCSCiT06C12.10.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z81116 Genomic DNA. Translation: CAB03296.2 .
PIRi T24561.
RefSeqi NP_506971.2. NM_074570.4.
UniGenei Cel.23835.

3D structure databases

ProteinModelPortali O18037.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.T06C12.10.2.

Protein family/group databases

CAZyi GT21. Glycosyltransferase Family 21.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai T06C12.10 ; T06C12.10 ; WBGene00011517 .
GeneIDi 188169.
KEGGi cel:CELE_T06C12.10.
UCSCi T06C12.10.1. c. elegans.

Organism-specific databases

CTDi 188169.
WormBasei T06C12.10 ; CE31986 ; WBGene00011517 ; cgt-1.

Phylogenomic databases

eggNOGi COG1215.
GeneTreei ENSGT00390000012898.
HOGENOMi HOG000039663.
InParanoidi O18037.
OMAi EILFCAR.
PhylomeDBi O18037.

Enzyme and pathway databases

UniPathwayi UPA00222 .
Reactomei REACT_197713. Glycosphingolipid metabolism.

Miscellaneous databases

NextBioi 937850.

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
InterProi IPR025993. Ceramide_glucosylTrfase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
Pfami PF13506. Glyco_transf_21. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Ceramide glucosyltransferase of the nematode Caenorhabditis elegans is involved in oocyte formation and in early embryonic cell division."
    Nomura K.H., Murata D., Hayashi Y., Dejima K., Mizuguchi S., Kage-Nakadai E., Gengyo-Ando K., Mitani S., Hirabayashi Y., Ito M., Nomura K.
    Glycobiology 21:834-848(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY, PATHWAY, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiCGT1_CAEEL
AccessioniPrimary (citable) accession number: O18037
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2013
Last sequence update: March 1, 2003
Last modified: October 1, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3