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Protein

Nephrocystin-1-like protein

Gene

nph-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May be necessary for initial assembly of the cilium.1 Publication

GO - Biological processi

  • determination of adult lifespan Source: WormBase
  • neuronal signal transduction Source: WormBase
  • nonmotile primary cilium assembly Source: WormBase
  • protein localization Source: WormBase
  • response to hermaphrodite contact Source: WormBase
  • turning behavior involved in mating Source: WormBase
Complete GO annotation...

Keywords - Biological processi

Behavior, Cilium biogenesis/degradation

Enzyme and pathway databases

SignaLinkiO17972.

Names & Taxonomyi

Protein namesi
Recommended name:
Nephrocystin-1-like protein
Alternative name(s):
Nephronophthisis homolog
Gene namesi
Name:nph-1
ORF Names:M28.7
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiM28.7; CE16278; WBGene00010898; nph-1.

Subcellular locationi

GO - Cellular componenti

  • ciliary base Source: WormBase
  • ciliary transition zone Source: WormBase
  • nonmotile primary cilium Source: WormBase
Complete GO annotation...

Pathology & Biotechi

Disruption phenotypei

Impaired male mating behavior.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 682682Nephrocystin-1-like proteinPRO_0000159587Add
BLAST

Proteomic databases

PaxDbiO17972.

Expressioni

Tissue specificityi

Expressed in ciliated sensory neurons of the head (amphid neurons) and the tail in hermaphrodites (phasmid neurons) and males (sensory ray neurons).1 Publication

Gene expression databases

BgeeiWBGene00010898.

Interactioni

Protein-protein interaction databases

IntActiO17972. 11 interactions.
STRINGi6239.M28.7.

Structurei

3D structure databases

ProteinModelPortaliO17972.
SMRiO17972. Positions 217-275.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini215 – 27561SH3PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili10 – 10091Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi155 – 17319Gln/Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the nephrocystin-1 family.Curated
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiENOG410IE0Z. Eukaryota.
ENOG410XPXZ. LUCA.
GeneTreeiENSGT00390000007701.
HOGENOMiHOG000016775.
InParanoidiO17972.
KOiK19657.
OMAiYRITQTR.
OrthoDBiEOG091G05R3.
PhylomeDBiO17972.

Family and domain databases

InterProiIPR030642. NPHP1.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR15176:SF1. PTHR15176:SF1. 2 hits.
PfamiPF00018. SH3_1. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O17972-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIFGSILSL QDAINRFPQF EYQINRLEKE QKDTEAASRA SFRKHFVRQC
60 70 80 90 100
QELHRQLDDH RNRIEKAKTD ETYKKENALE QLDKLKQRLT ALSPEKEQLS
110 120 130 140 150
FSVSVDSQSE EEKPKMAAIG RRKSTMYNDD ESEDSDNDSE IIETDVQLDD
160 170 180 190 200
PLPSQPQPPQ QQHQQPQPKP RQPITITKPL ESKTLNERQE LDEVISRLQN
210 220 230 240 250
PSRGDSGEVM EPVVVRGNVF VAIDSWDAEA EGDLELIKGK KYRITQTRSD
260 270 280 290 300
GWWTALDEYG QRGLVPKTYL QHVKEKPKNV PSKVSSRLGV RDSVIGISTT
310 320 330 340 350
TDPSRREANR QASRVDDCLG KAYDNDTHLS LVCHMAPRLS TSNIGFHDLF
360 370 380 390 400
WSHYKDQVYK RTVHISKIIR LVRFEKMPLI EHKALVRMAL VDITNPKSTQ
410 420 430 440 450
IVSNVHTLVP RVKSSTWYFE KKESQTRSCI EFSDFVLRSN YRSPTVVLVV
460 470 480 490 500
EASHLVKTQI GIEEKSLGHT YLRLIIDDKA VPSRTNVLYL DDEVMTKMKL
510 520 530 540 550
PEASKRRVLV QVMDVPKDKV SYVDSLPDVI VFNALYLPFF HFYRRRAGTI
560 570 580 590 600
LIRDNRNPLS AEFISDPLLS VFPFVCDQHD IMDIMLKIWK TKKKVLAKKN
610 620 630 640 650
EAEQTAEFFQ TFLHTAFFIH GIRMISYDVK DDLTLSIRQQ TMQRFVDALN
660 670 680
KGLFKQFIAD QQCKPINIID YSLDLLGNHS ID
Length:682
Mass (Da):78,796
Last modified:August 1, 1998 - v2
Checksum:iF30CCFF8B44B552D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49911 Genomic DNA. Translation: CAA90133.1.
PIRiT23813.
RefSeqiNP_496298.1. NM_063897.4.
UniGeneiCel.14718.

Genome annotation databases

EnsemblMetazoaiM28.7; M28.7; WBGene00010898.
GeneIDi174643.
KEGGicel:CELE_M28.7.
UCSCiM28.7. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49911 Genomic DNA. Translation: CAA90133.1.
PIRiT23813.
RefSeqiNP_496298.1. NM_063897.4.
UniGeneiCel.14718.

3D structure databases

ProteinModelPortaliO17972.
SMRiO17972. Positions 217-275.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO17972. 11 interactions.
STRINGi6239.M28.7.

Proteomic databases

PaxDbiO17972.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiM28.7; M28.7; WBGene00010898.
GeneIDi174643.
KEGGicel:CELE_M28.7.
UCSCiM28.7. c. elegans.

Organism-specific databases

CTDi174643.
WormBaseiM28.7; CE16278; WBGene00010898; nph-1.

Phylogenomic databases

eggNOGiENOG410IE0Z. Eukaryota.
ENOG410XPXZ. LUCA.
GeneTreeiENSGT00390000007701.
HOGENOMiHOG000016775.
InParanoidiO17972.
KOiK19657.
OMAiYRITQTR.
OrthoDBiEOG091G05R3.
PhylomeDBiO17972.

Enzyme and pathway databases

SignaLinkiO17972.

Miscellaneous databases

PROiO17972.

Gene expression databases

BgeeiWBGene00010898.

Family and domain databases

InterProiIPR030642. NPHP1.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR15176:SF1. PTHR15176:SF1. 2 hits.
PfamiPF00018. SH3_1. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNPHP1_CAEEL
AccessioniPrimary (citable) accession number: O17972
Secondary accession number(s): Q21570
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.