##gff-version 3
O17966	UniProtKB	Chain	1	806	.	.	.	ID=PRO_0000330482;Note=DNA topoisomerase 1	
O17966	UniProtKB	Domain	474	803	.	.	.	Note=Topo IB-type catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01382	
O17966	UniProtKB	Region	1	236	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
O17966	UniProtKB	Region	467	468	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250	
O17966	UniProtKB	Region	530	535	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250	
O17966	UniProtKB	Region	634	636	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250	
O17966	UniProtKB	Compositional bias	1	21	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
O17966	UniProtKB	Compositional bias	22	100	.	.	.	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
O17966	UniProtKB	Compositional bias	151	188	.	.	.	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
O17966	UniProtKB	Compositional bias	213	236	.	.	.	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
O17966	UniProtKB	Active site	761	761	.	.	.	Note=O-(3'-phospho-DNA)-tyrosine intermediate;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01382,ECO:0000255|PROSITE-ProRule:PRU10130	
O17966	UniProtKB	Site	358	358	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250	
O17966	UniProtKB	Site	406	406	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250	
O17966	UniProtKB	Site	454	454	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250	
O17966	UniProtKB	Site	485	485	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250	
O17966	UniProtKB	Site	543	543	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250	
O17966	UniProtKB	Site	581	581	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250	
O17966	UniProtKB	Site	623	623	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250	
O17966	UniProtKB	Site	681	681	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250	
O17966	UniProtKB	Site	699	699	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250	
O17966	UniProtKB	Alternative sequence	134	205	.	.	.	ID=VSP_033045;Note=In isoform b. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305	
O17966	UniProtKB	Sequence conflict	172	172	.	.	.	Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305