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Protein

Nuclear hormone receptor family member nhr-53

Gene

nhr-53

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Orphan nuclear receptor.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi20 – 95Nuclear receptorPROSITE-ProRule annotationAdd BLAST76
Zinc fingeri23 – 43NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri59 – 83NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear hormone receptor family member nhr-53
Gene namesi
Name:nhr-53
ORF Names:K06B4.11
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiK06B4.11 ; CE27770 ; WBGene00003643 ; nhr-53

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000537871 – 364Nuclear hormone receptor family member nhr-53Add BLAST364

Proteomic databases

PaxDbiO17933

Expressioni

Gene expression databases

BgeeiWBGene00003643

Interactioni

Protein-protein interaction databases

BioGridi45046, 4 interactors
IntActiO17933, 7 interactors
STRINGi6239.K06B4.11

Structurei

3D structure databases

ProteinModelPortaliO17933
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini110 – 363NR LBDPROSITE-ProRule annotationAdd BLAST254

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri23 – 43NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri59 – 83NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00530000064422
HOGENOMiHOG000237300
InParanoidiO17933
OMAiFLCEAFP
OrthoDBiEOG091G0BF9
PhylomeDBiO17933

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

O17933-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSPTHLLNN FESSSSQGPP SYCLICCEVA DGHHFGAAAC RACAAFFRRT
60 70 80 90 100
VQLNKVHDCP KNGQCFILSN VRNMCRACRY EKCLEVGMQR SSVQQKRDQL
110 120 130 140 150
GRRDGLPTNR EEPVLDTMRR AYEKLLVVRK KVHNRQENQL PRAISFNELQ
160 170 180 190 200
VVYQNEMTVI YQFLCEAFPE YSELLPDTKR SLFKNFFLPF TLLESSYYGY
210 220 230 240 250
LTKQENVMLI PSGDYVDLAH LESYFNNNHH TFSQKDTISM FAQQFRMLHT
260 270 280 290 300
SITVPLSAEN VDVNEFLALA AIILWESDLE VEADRKNVQE EAVKIKSAII
310 320 330 340 350
KDLLFHYQSI NVYADVAMRL GAVLSILPSI QRASHRFHEY MEIKNLLNLY
360
ALPKNLYDMF SPTS
Length:364
Mass (Da):41,980
Last modified:January 31, 2002 - v3
Checksum:i6E6016AAA5AC9F2E
GO

Sequence cautioni

The sequence AAG15147 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAG15148 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF273798 mRNA Translation: AAG15147.1 Different initiation.
AF273799 mRNA Translation: AAG15148.1 Different initiation.
Z83233 Genomic DNA Translation: CAB05768.2
PIRiT23372
RefSeqiNP_741644.1, NM_171556.4
UniGeneiCel.19468

Genome annotation databases

EnsemblMetazoaiK06B4.11; K06B4.11; WBGene00003643
GeneIDi180053
KEGGicel:CELE_K06B4.11
UCSCiK06B4.11 c. elegans

Similar proteinsi

Entry informationi

Entry nameiNHR53_CAEEL
AccessioniPrimary (citable) accession number: O17933
Secondary accession number(s): Q9GTG0, Q9GTG1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 31, 2002
Last modified: March 28, 2018
This is version 133 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health