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Protein

Putative H/ACA ribonucleoprotein complex subunit 4

Gene

K01G5.5

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays a central role in ribosomal RNA processing. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity).By similarity

Catalytic activityi

RNA uridine = RNA pseudouridine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei113NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Ribonucleoprotein, RNA-binding
Biological processRibosome biogenesis, rRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Putative H/ACA ribonucleoprotein complex subunit 4 (EC:5.4.99.-)
Gene namesi
ORF Names:K01G5.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiK01G5.5 ; CE16195 ; WBGene00010478

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001219881 – 445Putative H/ACA ribonucleoprotein complex subunit 4Add BLAST445

Proteomic databases

EPDiO17919
PaxDbiO17919
PeptideAtlasiO17919
PRIDEiO17919

PTM databases

iPTMnetiO17919

Expressioni

Gene expression databases

BgeeiWBGene00010478

Interactioni

Subunit structurei

Component of the small nucleolar ribonucleoprotein particle containing H/ACA-type snoRNAs (H/ACA snoRNPs).By similarity

Protein-protein interaction databases

BioGridi41691, 1 interactor
DIPiDIP-25862N
IntActiO17919, 1 interactor
STRINGi6239.K01G5.5.1

Structurei

3D structure databases

ProteinModelPortaliO17919
SMRiO17919
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini284 – 359PUAPROSITE-ProRule annotationAdd BLAST76

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi421 – 425Poly-Glu5

Sequence similaritiesi

Belongs to the pseudouridine synthase TruB family.Curated

Phylogenomic databases

eggNOGiKOG2529 Eukaryota
COG0130 LUCA
GeneTreeiENSGT00510000047092
HOGENOMiHOG000231224
InParanoidiO17919
KOiK11131
OMAiIYQRPPL
OrthoDBiEOG091G079R
PhylomeDBiO17919

Family and domain databases

InterProiView protein in InterPro
IPR012960 Dyskerin-like
IPR020103 PsdUridine_synth_cat_dom_sf
IPR002501 PsdUridine_synth_N
IPR002478 PUA
IPR015947 PUA-like_sf
IPR004802 tRNA_PsdUridine_synth_B_fam
IPR032819 TruB_C
IPR004521 Uncharacterised_CHP00451
PANTHERiPTHR23127 PTHR23127, 1 hit
PfamiView protein in Pfam
PF08068 DKCLD, 1 hit
PF01472 PUA, 1 hit
PF16198 TruB_C_2, 1 hit
PF01509 TruB_N, 1 hit
SMARTiView protein in SMART
SM01136 DKCLD, 1 hit
SM00359 PUA, 1 hit
SUPFAMiSSF55120 SSF55120, 1 hit
SSF88697 SSF88697, 1 hit
TIGRFAMsiTIGR00425 CBF5, 1 hit
TIGR00451 unchar_dom_2, 1 hit
PROSITEiView protein in PROSITE
PS50890 PUA, 1 hit

Sequencei

Sequence statusi: Complete.

O17919-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKKDKRSKL EGDDLAEAQQ KGSFQLPSSN ETAKLDASQW PLLLKNYDKL
60 70 80 90 100
NVRTNHYTPH VEGVSPLKRD IKNYISSGFF NLDKPSNPSS HEVVSWIKRI
110 120 130 140 150
LRCEKTGHSG TLDPKVSGCL IVCIDRTTRL AKSQQGAGKE YICIFKLHEE
160 170 180 190 200
VEDDRKVKQA LEKLTGALFQ RPPLISAVKR QLRIRTVYEN KFIEYDPAQQ
210 220 230 240 250
MGIFNCICES GTYVRTICVH LGLILGCGGQ MQELRRNRSG ICDENENMVT
260 270 280 290 300
MHDVLDAQYL LDTQKDESYM RHIVRPLEAL LTQHKRVVVK DSCINAICYG
310 320 330 340 350
AKILIPGILR YDDDIEVGKE IVIMSTKGEA ICIAIAQMNT STIASVDHGV
360 370 380 390 400
VAKSKRVIME RDVYGRKWGL GPVASKKKQM VKDGLLDKFG KPNDTTPKSW
410 420 430 440
AKEYVQTSTK KEVKKEETPD EEEEEAPKKK SKKSKKQESS DSDSD
Length:445
Mass (Da):50,211
Last modified:January 1, 1998 - v1
Checksum:i12F445A78E4A6B88
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z92803 Genomic DNA Translation: CAB07244.1
PIRiT23199
RefSeqiNP_499370.1, NM_066969.4
UniGeneiCel.7654

Genome annotation databases

EnsemblMetazoaiK01G5.5; K01G5.5; WBGene00010478
GeneIDi176504
KEGGicel:CELE_K01G5.5
UCSCiK01G5.5.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiDKC1_CAEEL
AccessioniPrimary (citable) accession number: O17919
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

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