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Protein

Putative H/ACA ribonucleoprotein complex subunit 4

Gene

K01G5.5

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Plays a central role in ribosomal RNA processing. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity).By similarity

Catalytic activityi

RNA uridine = RNA pseudouridine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei113NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Ribonucleoprotein, RNA-binding
Biological processRibosome biogenesis, rRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Putative H/ACA ribonucleoprotein complex subunit 4 (EC:5.4.99.-)
Gene namesi
ORF Names:K01G5.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiK01G5.5; CE16195; WBGene00010478.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001219881 – 445Putative H/ACA ribonucleoprotein complex subunit 4Add BLAST445

Proteomic databases

EPDiO17919.
PaxDbiO17919.
PeptideAtlasiO17919.
PRIDEiO17919.

PTM databases

iPTMnetiO17919.

Expressioni

Gene expression databases

BgeeiWBGene00010478.

Interactioni

Subunit structurei

Component of the small nucleolar ribonucleoprotein particle containing H/ACA-type snoRNAs (H/ACA snoRNPs).By similarity

Protein-protein interaction databases

BioGridi41691. 1 interactor.
DIPiDIP-25862N.
IntActiO17919. 2 interactors.
MINTiMINT-1040832.
STRINGi6239.K01G5.5.1.

Structurei

3D structure databases

ProteinModelPortaliO17919.
SMRiO17919.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini284 – 359PUAPROSITE-ProRule annotationAdd BLAST76

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi421 – 425Poly-Glu5

Sequence similaritiesi

Belongs to the pseudouridine synthase TruB family.Curated

Phylogenomic databases

eggNOGiKOG2529. Eukaryota.
COG0130. LUCA.
GeneTreeiENSGT00510000047092.
HOGENOMiHOG000231224.
InParanoidiO17919.
KOiK11131.
OMAiIYQRPPL.
OrthoDBiEOG091G079R.
PhylomeDBiO17919.

Family and domain databases

Gene3Di2.30.130.10. 1 hit.
InterProiView protein in InterPro
IPR012960. Dyskerin-like.
IPR020103. PsdUridine_synth_cat_dom.
IPR002501. PsdUridine_synth_N.
IPR002478. PUA.
IPR015947. PUA-like_domain.
IPR004802. tRNA_PsdUridine_synth_B_fam.
IPR032819. TruB_C.
IPR004521. Uncharacterised_CHP00451.
PANTHERiPTHR23127. PTHR23127. 1 hit.
PfamiView protein in Pfam
PF08068. DKCLD. 1 hit.
PF01472. PUA. 1 hit.
PF16198. TruB_C_2. 1 hit.
PF01509. TruB_N. 1 hit.
SMARTiView protein in SMART
SM01136. DKCLD. 1 hit.
SM00359. PUA. 1 hit.
SUPFAMiSSF55120. SSF55120. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR00425. CBF5. 1 hit.
TIGR00451. unchar_dom_2. 1 hit.
PROSITEiView protein in PROSITE
PS50890. PUA. 1 hit.

Sequencei

Sequence statusi: Complete.

O17919-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKKDKRSKL EGDDLAEAQQ KGSFQLPSSN ETAKLDASQW PLLLKNYDKL
60 70 80 90 100
NVRTNHYTPH VEGVSPLKRD IKNYISSGFF NLDKPSNPSS HEVVSWIKRI
110 120 130 140 150
LRCEKTGHSG TLDPKVSGCL IVCIDRTTRL AKSQQGAGKE YICIFKLHEE
160 170 180 190 200
VEDDRKVKQA LEKLTGALFQ RPPLISAVKR QLRIRTVYEN KFIEYDPAQQ
210 220 230 240 250
MGIFNCICES GTYVRTICVH LGLILGCGGQ MQELRRNRSG ICDENENMVT
260 270 280 290 300
MHDVLDAQYL LDTQKDESYM RHIVRPLEAL LTQHKRVVVK DSCINAICYG
310 320 330 340 350
AKILIPGILR YDDDIEVGKE IVIMSTKGEA ICIAIAQMNT STIASVDHGV
360 370 380 390 400
VAKSKRVIME RDVYGRKWGL GPVASKKKQM VKDGLLDKFG KPNDTTPKSW
410 420 430 440
AKEYVQTSTK KEVKKEETPD EEEEEAPKKK SKKSKKQESS DSDSD
Length:445
Mass (Da):50,211
Last modified:January 1, 1998 - v1
Checksum:i12F445A78E4A6B88
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z92803 Genomic DNA. Translation: CAB07244.1.
PIRiT23199.
RefSeqiNP_499370.1. NM_066969.4.
UniGeneiCel.7654.

Genome annotation databases

EnsemblMetazoaiK01G5.5; K01G5.5; WBGene00010478.
GeneIDi176504.
KEGGicel:CELE_K01G5.5.
UCSCiK01G5.5.1. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiDKC1_CAEEL
AccessioniPrimary (citable) accession number: O17919
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: September 27, 2017
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families