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Protein

Putative H/ACA ribonucleoprotein complex subunit 4

Gene

K01G5.5

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Plays a central role in ribosomal RNA processing. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity).By similarity

Catalytic activityi

RNA uridine = RNA pseudouridine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei113 – 1131NucleophileBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Ribonucleoprotein

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative H/ACA ribonucleoprotein complex subunit 4 (EC:5.4.99.-)
Gene namesi
ORF Names:K01G5.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiK01G5.5; CE16195; WBGene00010478.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445Putative H/ACA ribonucleoprotein complex subunit 4PRO_0000121988Add
BLAST

Proteomic databases

EPDiO17919.
PaxDbiO17919.

PTM databases

iPTMnetiO17919.

Interactioni

Subunit structurei

Component of the small nucleolar ribonucleoprotein particle containing H/ACA-type snoRNAs (H/ACA snoRNPs).By similarity

Protein-protein interaction databases

BioGridi41691. 1 interaction.
DIPiDIP-25862N.
IntActiO17919. 1 interaction.
MINTiMINT-1040832.
STRINGi6239.K01G5.5.1.

Structurei

3D structure databases

ProteinModelPortaliO17919.
SMRiO17919. Positions 36-396.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini284 – 35976PUAPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi421 – 4255Poly-Glu

Sequence similaritiesi

Belongs to the pseudouridine synthase TruB family.Curated
Contains 1 PUA domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2529. Eukaryota.
COG0130. LUCA.
GeneTreeiENSGT00510000047092.
HOGENOMiHOG000231224.
InParanoidiO17919.
KOiK11131.
OMAiMDNTRDE.
OrthoDBiEOG7QC7W0.
PhylomeDBiO17919.

Family and domain databases

Gene3Di2.30.130.10. 1 hit.
InterProiIPR012960. Dyskerin-like.
IPR020103. PsdUridine_synth_cat_dom.
IPR002501. PsdUridine_synth_N.
IPR002478. PUA.
IPR015947. PUA-like_domain.
IPR004802. tRNA_PsdUridine_synth_B_fam.
IPR032819. TruB_C.
IPR004521. Uncharacterised_CHP00451.
[Graphical view]
PANTHERiPTHR23127. PTHR23127. 1 hit.
PfamiPF08068. DKCLD. 1 hit.
PF01472. PUA. 1 hit.
PF16198. TruB_C_2. 1 hit.
PF01509. TruB_N. 1 hit.
[Graphical view]
SMARTiSM01136. DKCLD. 1 hit.
SM00359. PUA. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR00425. CBF5. 1 hit.
TIGR00451. unchar_dom_2. 1 hit.
PROSITEiPS50890. PUA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O17919-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKKDKRSKL EGDDLAEAQQ KGSFQLPSSN ETAKLDASQW PLLLKNYDKL
60 70 80 90 100
NVRTNHYTPH VEGVSPLKRD IKNYISSGFF NLDKPSNPSS HEVVSWIKRI
110 120 130 140 150
LRCEKTGHSG TLDPKVSGCL IVCIDRTTRL AKSQQGAGKE YICIFKLHEE
160 170 180 190 200
VEDDRKVKQA LEKLTGALFQ RPPLISAVKR QLRIRTVYEN KFIEYDPAQQ
210 220 230 240 250
MGIFNCICES GTYVRTICVH LGLILGCGGQ MQELRRNRSG ICDENENMVT
260 270 280 290 300
MHDVLDAQYL LDTQKDESYM RHIVRPLEAL LTQHKRVVVK DSCINAICYG
310 320 330 340 350
AKILIPGILR YDDDIEVGKE IVIMSTKGEA ICIAIAQMNT STIASVDHGV
360 370 380 390 400
VAKSKRVIME RDVYGRKWGL GPVASKKKQM VKDGLLDKFG KPNDTTPKSW
410 420 430 440
AKEYVQTSTK KEVKKEETPD EEEEEAPKKK SKKSKKQESS DSDSD
Length:445
Mass (Da):50,211
Last modified:January 1, 1998 - v1
Checksum:i12F445A78E4A6B88
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z92803 Genomic DNA. Translation: CAB07244.1.
PIRiT23199.
RefSeqiNP_499370.1. NM_066969.4.
UniGeneiCel.7654.

Genome annotation databases

EnsemblMetazoaiK01G5.5; K01G5.5; WBGene00010478.
GeneIDi176504.
KEGGicel:CELE_K01G5.5.
UCSCiK01G5.5.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z92803 Genomic DNA. Translation: CAB07244.1.
PIRiT23199.
RefSeqiNP_499370.1. NM_066969.4.
UniGeneiCel.7654.

3D structure databases

ProteinModelPortaliO17919.
SMRiO17919. Positions 36-396.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi41691. 1 interaction.
DIPiDIP-25862N.
IntActiO17919. 1 interaction.
MINTiMINT-1040832.
STRINGi6239.K01G5.5.1.

PTM databases

iPTMnetiO17919.

Proteomic databases

EPDiO17919.
PaxDbiO17919.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiK01G5.5; K01G5.5; WBGene00010478.
GeneIDi176504.
KEGGicel:CELE_K01G5.5.
UCSCiK01G5.5.1. c. elegans.

Organism-specific databases

CTDi176504.
WormBaseiK01G5.5; CE16195; WBGene00010478.

Phylogenomic databases

eggNOGiKOG2529. Eukaryota.
COG0130. LUCA.
GeneTreeiENSGT00510000047092.
HOGENOMiHOG000231224.
InParanoidiO17919.
KOiK11131.
OMAiMDNTRDE.
OrthoDBiEOG7QC7W0.
PhylomeDBiO17919.

Miscellaneous databases

PROiO17919.

Family and domain databases

Gene3Di2.30.130.10. 1 hit.
InterProiIPR012960. Dyskerin-like.
IPR020103. PsdUridine_synth_cat_dom.
IPR002501. PsdUridine_synth_N.
IPR002478. PUA.
IPR015947. PUA-like_domain.
IPR004802. tRNA_PsdUridine_synth_B_fam.
IPR032819. TruB_C.
IPR004521. Uncharacterised_CHP00451.
[Graphical view]
PANTHERiPTHR23127. PTHR23127. 1 hit.
PfamiPF08068. DKCLD. 1 hit.
PF01472. PUA. 1 hit.
PF16198. TruB_C_2. 1 hit.
PF01509. TruB_N. 1 hit.
[Graphical view]
SMARTiSM01136. DKCLD. 1 hit.
SM00359. PUA. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR00425. CBF5. 1 hit.
TIGR00451. unchar_dom_2. 1 hit.
PROSITEiPS50890. PUA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiDKC1_CAEEL
AccessioniPrimary (citable) accession number: O17919
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: June 8, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.