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Protein

GTP-binding nuclear protein ran-1

Gene

ran-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ran GTPase system comprises ran-1, ran-2 and ran-3 and is essential in nucleocytoplasmic transport. Ran-1 is a GTP-binding protein that mediates the interaction between mitotic chromosomes and kinetochore microtubules. Plays a crucial role in nuclear envelope assembly at the end of each cell division. Required for the import of protein into the nucleus and also for RNA export. RCC1 (ran-3)/Ran (ran-1) complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA.1 Publication

Miscellaneous

Loss of ran-1 results in failure of correct attachment of kinetochore microtubules to mitotic chromosomes and the resultant loss of correct chromosome segregation. The number and the location of centrosomes are normal, and astral mictrotubules also seem unaffected. Nuclear envelope is not reestablished at the end of each cell division.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei67GTP; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi17 – 24GTPBy similarity8
Nucleotide bindingi121 – 124GTPBy similarity4
Nucleotide bindingi149 – 151GTPBy similarity3

GO - Molecular functioni

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • embryo development ending in birth or egg hatching Source: WormBase
  • oogenesis Source: WormBase
  • protein import into nucleus Source: GO_Central
  • ribosomal subunit export from nucleus Source: GO_Central

Keywordsi

Biological processCell cycle, Cell division, Mitosis, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF)

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding nuclear protein ran-1
Alternative name(s):
Ras-related nuclear protein 1
Gene namesi
Name:ran-1
ORF Names:K01G5.4
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiK01G5.4 ; CE16194 ; WBGene00004302 ; ran-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002087081 – 215GTP-binding nuclear protein ran-1Add BLAST215

Proteomic databases

EPDiO17915
PaxDbiO17915
PeptideAtlasiO17915
PRIDEiO17915

PTM databases

iPTMnetiO17915

Expressioni

Gene expression databases

BgeeiWBGene00004302

Interactioni

Subunit structurei

Found in a nuclear export complex with RanGTP, exportin and pre-miRNA (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
npp-9Q86G906EBI-324099,EBI-313076

Protein-protein interaction databases

BioGridi41690, 26 interactors
DIPiDIP-25217N
IntActiO17915, 17 interactors
STRINGi6239.K01G5.4.1

Structurei

3D structure databases

ProteinModelPortaliO17915
SMRiO17915
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ran family.Curated

Phylogenomic databases

eggNOGiKOG0096 Eukaryota
ENOG410XNRS LUCA
GeneTreeiENSGT00840000129836
HOGENOMiHOG000216664
InParanoidiO17915
KOiK07936
OMAiYNVWDTA
OrthoDBiEOG091G0L3X
PhylomeDBiO17915

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR002041 Ran_GTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PANTHERiPTHR24071 PTHR24071, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
PRINTSiPR00627 GTPRANTC4
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51418 RAN, 1 hit

Sequencei

Sequence statusi: Complete.

O17915-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGGDGIPTF KLVLVGDGGT GKTTFVKRHL TGEFEKKYVA TLGVEVHPLV
60 70 80 90 100
FHTNRGQIRF NVWDTAGQEK FGGLRDGYYI QGQCAIIMFD VTARVTYKNV
110 120 130 140 150
PNWHRDLARV CENIPIVLCG NKVDVKDRKV KAKTITFHRK KNLQYYDISA
160 170 180 190 200
KSNYNFEKPF LWLARKLLGD PNLEFVAMPA LAPPEVQMDP AMIAEYEKDL
210
DNAAKADLPD DDDDL
Length:215
Mass (Da):24,254
Last modified:January 1, 1998 - v1
Checksum:i90B32613588745E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z92803 Genomic DNA Translation: CAB07240.1
PIRiT23195
RefSeqiNP_499369.1, NM_066968.5
UniGeneiCel.17475

Genome annotation databases

EnsemblMetazoaiK01G5.4; K01G5.4; WBGene00004302
GeneIDi176503
KEGGicel:CELE_K01G5.4
UCSCiK01G5.4.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiRAN_CAEEL
AccessioniPrimary (citable) accession number: O17915
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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