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Protein

GTP-binding nuclear protein ran-1

Gene

ran-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Ran GTPase system comprises ran-1, ran-2 and ran-3 and is essential in nucleocytoplasmic transport. Ran-1 is a GTP-binding protein that mediates the interaction between mitotic chromosomes and kinetochore microtubules. Plays a crucial role in nuclear envelope assembly at the end of each cell division. Required for the import of protein into the nucleus and also for RNA export. RCC1 (ran-3)/Ran (ran-1) complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA.1 Publication

Miscellaneous

Loss of ran-1 results in failure of correct attachment of kinetochore microtubules to mitotic chromosomes and the resultant loss of correct chromosome segregation. The number and the location of centrosomes are normal, and astral mictrotubules also seem unaffected. Nuclear envelope is not reestablished at the end of each cell division.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 23GTPBy similarity8
Nucleotide bindingi64 – 68GTPBy similarity5
Nucleotide bindingi121 – 124GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • embryo development ending in birth or egg hatching Source: WormBase
  • oogenesis Source: WormBase
  • protein import into nucleus Source: GO_Central
  • ribosomal subunit export from nucleus Source: GO_Central
  • signal transduction Source: InterPro

Keywordsi

Biological processCell cycle, Cell division, Mitosis, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-1655829. Regulation of cholesterol biosynthesis by SREBP (SREBF).

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding nuclear protein ran-1
Alternative name(s):
Ras-related nuclear protein 1
Gene namesi
Name:ran-1
ORF Names:K01G5.4
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiK01G5.4; CE16194; WBGene00004302; ran-1.

Subcellular locationi

  • Nucleus 1 Publication
  • Chromosomecentromerekinetochore 1 Publication
  • Chromosome 1 Publication

  • Note: At interphase, ran-1 is localized to the nucleus and the nuclear envelope. At prometaphase, ran-1 is still localized to the nuclear envelope. When the nuclear envelope begins to disassemble at M phase (early metaphase), ran-1 is localized throughout the entire cell. At late metaphase, ran-1 localizes to the kinetochore regions, this persists until anaphase. At telophase, ran-1 is localized around the decondensing chromosomes.

GO - Cellular componenti

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002087081 – 215GTP-binding nuclear protein ran-1Add BLAST215

Proteomic databases

EPDiO17915.
PaxDbiO17915.
PeptideAtlasiO17915.
PRIDEiO17915.

PTM databases

iPTMnetiO17915.

Expressioni

Gene expression databases

BgeeiWBGene00004302.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
npp-9Q86G906EBI-324099,EBI-313076

Protein-protein interaction databases

BioGridi41690. 26 interactors.
DIPiDIP-25217N.
IntActiO17915. 17 interactors.
MINTiMINT-1038463.
STRINGi6239.K01G5.4.1.

Structurei

3D structure databases

ProteinModelPortaliO17915.
SMRiO17915.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ran family.Curated

Phylogenomic databases

eggNOGiKOG0096. Eukaryota.
ENOG410XNRS. LUCA.
GeneTreeiENSGT00840000129836.
HOGENOMiHOG000216664.
InParanoidiO17915.
KOiK07936.
OMAiYNVWDTA.
OrthoDBiEOG091G0L3X.
PhylomeDBiO17915.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR002041. Ran_GTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
PfamiView protein in Pfam
PF00071. Ras. 1 hit.
PRINTSiPR00627. GTPRANTC4.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51418. RAN. 1 hit.

Sequencei

Sequence statusi: Complete.

O17915-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGGDGIPTF KLVLVGDGGT GKTTFVKRHL TGEFEKKYVA TLGVEVHPLV
60 70 80 90 100
FHTNRGQIRF NVWDTAGQEK FGGLRDGYYI QGQCAIIMFD VTARVTYKNV
110 120 130 140 150
PNWHRDLARV CENIPIVLCG NKVDVKDRKV KAKTITFHRK KNLQYYDISA
160 170 180 190 200
KSNYNFEKPF LWLARKLLGD PNLEFVAMPA LAPPEVQMDP AMIAEYEKDL
210
DNAAKADLPD DDDDL
Length:215
Mass (Da):24,254
Last modified:January 1, 1998 - v1
Checksum:i90B32613588745E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z92803 Genomic DNA. Translation: CAB07240.1.
PIRiT23195.
RefSeqiNP_499369.1. NM_066968.5.
UniGeneiCel.17475.

Genome annotation databases

EnsemblMetazoaiK01G5.4; K01G5.4; WBGene00004302.
GeneIDi176503.
KEGGicel:CELE_K01G5.4.
UCSCiK01G5.4.1. c. elegans.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRAN_CAEEL
AccessioniPrimary (citable) accession number: O17915
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: January 1, 1998
Last modified: June 7, 2017
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families