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O17850 (ATX3_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ataxin-3 homolog

EC=3.4.19.12
Alternative name(s):
Machado-Joseph disease-like protein
Gene names
Name:atx-3
ORF Names:F28F8.6
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length317 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Interacts with key regulators of transcription and represses transcription. Acts as a histone-binding protein that regulates transcription. Acts as a deubiquitinating enzyme By similarity. UniProtKB P54252

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subcellular location

Nucleus By similarity UniProtKB P54252.

Sequence similarities

Contains 1 Josephin domain.

Contains 2 UIM (ubiquitin-interacting motif) repeats.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

cdc-48.2P548123EBI-320650,EBI-320265

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 317317Ataxin-3 homolog
PRO_0000053835

Regions

Domain7 – 178172Josephin
Repeat219 – 23618UIM 1
Repeat247 – 26418UIM 2

Sites

Active site201Nucleophile By similarity
Active site1171Proton acceptor By similarity
Active site1321 By similarity

Sequences

Sequence LengthMass (Da)Tools
O17850 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 31798FD62667FB19

FASTA31735,864
        10         20         30         40         50         60 
MSKDDPINSI FFEHQEAALC AQHALNMLLQ DALYKWQDLR DLAIQMDKME QQILGNANPT 

        70         80         90        100        110        120 
PGRSENMNES GYFSIQVLEK ALETFSLKLT NIENPAMVDY KNNPLTARAY ICNLREHWFV 

       130        140        150        160        170        180 
LRKFGNQWFE LNSVNRGPKL LSDTYVSMFL HQVSSEGYSI FVVQGVLPRS DADDLISLCP 

       190        200        210        220        230        240 
VVPPKVTPKK EQKLEKVMTK FFNTVGKRLG GGSGAPPDSQ EEKDLAIAFA MSMETKDGSE 

       250        260        270        280        290        300 
VSRSSAEIDE ENLRKAIELS QAPGPSEPAE IPLLTRSRSS TPPGASEPFS NAEQQRRDRQ 

       310 
KFLERFEKKK EERNDEK 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
[2]"Structural modeling of ataxin-3 reveals distant homology to adaptins."
Albrecht M., Hoffmann D., Evert B.O., Schmitt I., Wuellner U., Lengauer T.
Proteins 50:355-370(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: 3D-STRUCTURE MODELING.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z81071 Genomic DNA. Translation: CAB03016.1.
PIRT21511.
RefSeqNP_506873.1. NM_074472.7.
UniGeneCel.6510.

3D structure databases

ProteinModelPortalO17850.
SMRO17850. Positions 7-168, 217-266.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid45043. 2 interactions.
DIPDIP-27501N.
IntActO17850. 3 interactions.
MINTMINT-1090524.
STRING6239.F28F8.6.1.

Protein family/group databases

MEROPSC86.003.

Proteomic databases

PaxDbO17850.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaF28F8.6.1; F28F8.6.1; F28F8.6.
F28F8.6.2; F28F8.6.2; F28F8.6.
F28F8.6.3; F28F8.6.3; F28F8.6.
GeneID180049.
KEGGcel:CELE_F28F8.6.
UCSCF28F8.6.1. c. elegans.

Organism-specific databases

CTD180049.
WormBaseF28F8.6; CE09760; WBGene00006446; atx-3.

Phylogenomic databases

eggNOGNOG327234.
HOGENOMHOG000006034.
InParanoidO17850.
KOK11863.
OMANALKFWG.
OrthoDBEOG779NZ3.
PhylomeDBO17850.

Family and domain databases

InterProIPR006155. Josephin.
IPR003903. Ubiquitin-int_motif.
[Graphical view]
PfamPF02099. Josephin. 1 hit.
PF02809. UIM. 2 hits.
[Graphical view]
PRINTSPR01233. JOSEPHIN.
SMARTSM00726. UIM. 2 hits.
[Graphical view]
PROSITEPS50957. JOSEPHIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio907892.
PROO17850.

Entry information

Entry nameATX3_CAEEL
AccessionPrimary (citable) accession number: O17850
Entry history
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: January 1, 1998
Last modified: April 16, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase