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O17850

- ATX3_CAEEL

UniProt

O17850 - ATX3_CAEEL

Protein

Ataxin-3 homolog

Gene

atx-3

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Interacts with key regulators of transcription and represses transcription. Acts as a histone-binding protein that regulates transcription. Acts as a deubiquitinating enzyme By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei20 – 201NucleophilePROSITE-ProRule annotation
    Active sitei117 – 1171Proton acceptorPROSITE-ProRule annotation
    Active sitei132 – 1321PROSITE-ProRule annotation

    GO - Molecular functioni

    1. omega peptidase activity Source: InterPro
    2. protein binding Source: IntAct
    3. ubiquitin-specific protease activity Source: WormBase

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. synaptic transmission Source: WormBase
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Transcription, Transcription regulation, Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC86.003.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ataxin-3 homolog (EC:3.4.19.12)
    Alternative name(s):
    Machado-Joseph disease-like protein
    Gene namesi
    Name:atx-3
    ORF Names:F28F8.6
    OrganismiCaenorhabditis elegansImported
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome V

    Organism-specific databases

    WormBaseiF28F8.6; CE09760; WBGene00006446; atx-3.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: WormBase
    2. nucleus Source: WormBase

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 317317Ataxin-3 homologPRO_0000053835Add
    BLAST

    Proteomic databases

    PaxDbiO17850.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    cdc-48.2P548123EBI-320650,EBI-320265

    Protein-protein interaction databases

    BioGridi45043. 2 interactions.
    DIPiDIP-27501N.
    IntActiO17850. 3 interactions.
    MINTiMINT-1090524.
    STRINGi6239.F28F8.6.1.

    Structurei

    3D structure databases

    ProteinModelPortaliO17850.
    SMRiO17850. Positions 7-168.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini7 – 178172JosephinPROSITE-ProRule annotationAdd
    BLAST
    Repeati219 – 23618UIM 1Add
    BLAST
    Repeati247 – 26418UIM 2Add
    BLAST

    Sequence similaritiesi

    Contains 1 Josephin domain.CuratedPROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG327234.
    GeneTreeiENSGT00390000001830.
    HOGENOMiHOG000006034.
    InParanoidiO17850.
    KOiK11863.
    OMAiNALKFWG.
    OrthoDBiEOG779NZ3.
    PhylomeDBiO17850.

    Family and domain databases

    InterProiIPR006155. Josephin.
    IPR003903. Ubiquitin-int_motif.
    [Graphical view]
    PfamiPF02099. Josephin. 1 hit.
    PF02809. UIM. 2 hits.
    [Graphical view]
    PRINTSiPR01233. JOSEPHIN.
    SMARTiSM00726. UIM. 2 hits.
    [Graphical view]
    PROSITEiPS50957. JOSEPHIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O17850-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKDDPINSI FFEHQEAALC AQHALNMLLQ DALYKWQDLR DLAIQMDKME    50
    QQILGNANPT PGRSENMNES GYFSIQVLEK ALETFSLKLT NIENPAMVDY 100
    KNNPLTARAY ICNLREHWFV LRKFGNQWFE LNSVNRGPKL LSDTYVSMFL 150
    HQVSSEGYSI FVVQGVLPRS DADDLISLCP VVPPKVTPKK EQKLEKVMTK 200
    FFNTVGKRLG GGSGAPPDSQ EEKDLAIAFA MSMETKDGSE VSRSSAEIDE 250
    ENLRKAIELS QAPGPSEPAE IPLLTRSRSS TPPGASEPFS NAEQQRRDRQ 300
    KFLERFEKKK EERNDEK 317
    Length:317
    Mass (Da):35,864
    Last modified:January 1, 1998 - v1
    Checksum:i31798FD62667FB19
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z81071 Genomic DNA. Translation: CAB03016.1.
    PIRiT21511.
    RefSeqiNP_506873.1. NM_074472.7.
    UniGeneiCel.6510.

    Genome annotation databases

    EnsemblMetazoaiF28F8.6.1; F28F8.6.1; WBGene00006446.
    F28F8.6.2; F28F8.6.2; WBGene00006446.
    GeneIDi180049.
    KEGGicel:CELE_F28F8.6.
    UCSCiF28F8.6.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z81071 Genomic DNA. Translation: CAB03016.1 .
    PIRi T21511.
    RefSeqi NP_506873.1. NM_074472.7.
    UniGenei Cel.6510.

    3D structure databases

    ProteinModelPortali O17850.
    SMRi O17850. Positions 7-168.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 45043. 2 interactions.
    DIPi DIP-27501N.
    IntActi O17850. 3 interactions.
    MINTi MINT-1090524.
    STRINGi 6239.F28F8.6.1.

    Protein family/group databases

    MEROPSi C86.003.

    Proteomic databases

    PaxDbi O17850.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai F28F8.6.1 ; F28F8.6.1 ; WBGene00006446 .
    F28F8.6.2 ; F28F8.6.2 ; WBGene00006446 .
    GeneIDi 180049.
    KEGGi cel:CELE_F28F8.6.
    UCSCi F28F8.6.1. c. elegans.

    Organism-specific databases

    CTDi 180049.
    WormBasei F28F8.6 ; CE09760 ; WBGene00006446 ; atx-3.

    Phylogenomic databases

    eggNOGi NOG327234.
    GeneTreei ENSGT00390000001830.
    HOGENOMi HOG000006034.
    InParanoidi O17850.
    KOi K11863.
    OMAi NALKFWG.
    OrthoDBi EOG779NZ3.
    PhylomeDBi O17850.

    Miscellaneous databases

    NextBioi 907892.
    PROi O17850.

    Family and domain databases

    InterProi IPR006155. Josephin.
    IPR003903. Ubiquitin-int_motif.
    [Graphical view ]
    Pfami PF02099. Josephin. 1 hit.
    PF02809. UIM. 2 hits.
    [Graphical view ]
    PRINTSi PR01233. JOSEPHIN.
    SMARTi SM00726. UIM. 2 hits.
    [Graphical view ]
    PROSITEi PS50957. JOSEPHIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    2. "Structural modeling of ataxin-3 reveals distant homology to adaptins."
      Albrecht M., Hoffmann D., Evert B.O., Schmitt I., Wuellner U., Lengauer T.
      Proteins 50:355-370(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING.

    Entry informationi

    Entry nameiATX3_CAEEL
    AccessioniPrimary (citable) accession number: O17850
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 28, 2003
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3