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Protein

Ataxin-3 homolog

Gene

atx-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Interacts with key regulators of transcription and represses transcription. Acts as a histone-binding protein that regulates transcription. Acts as a deubiquitinating enzyme (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei20 – 201NucleophilePROSITE-ProRule annotation
Active sitei117 – 1171Proton acceptorPROSITE-ProRule annotation
Active sitei132 – 1321PROSITE-ProRule annotation

GO - Molecular functioni

  1. omega peptidase activity Source: InterPro
  2. ubiquitin-specific protease activity Source: WormBase

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. synaptic transmission Source: WormBase
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Transcription, Transcription regulation, Ubl conjugation pathway

Protein family/group databases

MEROPSiC86.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Ataxin-3 homolog (EC:3.4.19.12)
Alternative name(s):
Machado-Joseph disease-like protein
Gene namesi
Name:atx-3
ORF Names:F28F8.6
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiF28F8.6; CE09760; WBGene00006446; atx-3.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: WormBase
  2. nucleus Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317Ataxin-3 homologPRO_0000053835Add
BLAST

Proteomic databases

PaxDbiO17850.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
cdc-48.2P548123EBI-320650,EBI-320265

Protein-protein interaction databases

BioGridi45043. 4 interactions.
DIPiDIP-27501N.
IntActiO17850. 3 interactions.
MINTiMINT-1090524.
STRINGi6239.F28F8.6.1.

Structurei

3D structure databases

ProteinModelPortaliO17850.
SMRiO17850. Positions 7-168.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 178172JosephinPROSITE-ProRule annotationAdd
BLAST
Domaini219 – 23921UIM 1CuratedAdd
BLAST
Domaini247 – 26418UIM 2CuratedAdd
BLAST

Sequence similaritiesi

Contains 1 Josephin domain.PROSITE-ProRule annotationCurated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG327234.
GeneTreeiENSGT00390000001830.
HOGENOMiHOG000006034.
InParanoidiO17850.
KOiK11863.
OMAiNALKFWG.
OrthoDBiEOG779NZ3.
PhylomeDBiO17850.

Family and domain databases

InterProiIPR006155. Josephin.
IPR003903. Ubiquitin-int_motif.
[Graphical view]
PfamiPF02099. Josephin. 1 hit.
PF02809. UIM. 2 hits.
[Graphical view]
PRINTSiPR01233. JOSEPHIN.
SMARTiSM00726. UIM. 2 hits.
[Graphical view]
PROSITEiPS50957. JOSEPHIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O17850-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKDDPINSI FFEHQEAALC AQHALNMLLQ DALYKWQDLR DLAIQMDKME
60 70 80 90 100
QQILGNANPT PGRSENMNES GYFSIQVLEK ALETFSLKLT NIENPAMVDY
110 120 130 140 150
KNNPLTARAY ICNLREHWFV LRKFGNQWFE LNSVNRGPKL LSDTYVSMFL
160 170 180 190 200
HQVSSEGYSI FVVQGVLPRS DADDLISLCP VVPPKVTPKK EQKLEKVMTK
210 220 230 240 250
FFNTVGKRLG GGSGAPPDSQ EEKDLAIAFA MSMETKDGSE VSRSSAEIDE
260 270 280 290 300
ENLRKAIELS QAPGPSEPAE IPLLTRSRSS TPPGASEPFS NAEQQRRDRQ
310
KFLERFEKKK EERNDEK
Length:317
Mass (Da):35,864
Last modified:January 1, 1998 - v1
Checksum:i31798FD62667FB19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81071 Genomic DNA. Translation: CAB03016.1.
PIRiT21511.
RefSeqiNP_506873.1. NM_074472.7.
UniGeneiCel.6510.

Genome annotation databases

EnsemblMetazoaiF28F8.6.1; F28F8.6.1; WBGene00006446.
F28F8.6.2; F28F8.6.2; WBGene00006446.
GeneIDi180049.
KEGGicel:CELE_F28F8.6.
UCSCiF28F8.6.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81071 Genomic DNA. Translation: CAB03016.1.
PIRiT21511.
RefSeqiNP_506873.1. NM_074472.7.
UniGeneiCel.6510.

3D structure databases

ProteinModelPortaliO17850.
SMRiO17850. Positions 7-168.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi45043. 4 interactions.
DIPiDIP-27501N.
IntActiO17850. 3 interactions.
MINTiMINT-1090524.
STRINGi6239.F28F8.6.1.

Protein family/group databases

MEROPSiC86.003.

Proteomic databases

PaxDbiO17850.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF28F8.6.1; F28F8.6.1; WBGene00006446.
F28F8.6.2; F28F8.6.2; WBGene00006446.
GeneIDi180049.
KEGGicel:CELE_F28F8.6.
UCSCiF28F8.6.1. c. elegans.

Organism-specific databases

CTDi180049.
WormBaseiF28F8.6; CE09760; WBGene00006446; atx-3.

Phylogenomic databases

eggNOGiNOG327234.
GeneTreeiENSGT00390000001830.
HOGENOMiHOG000006034.
InParanoidiO17850.
KOiK11863.
OMAiNALKFWG.
OrthoDBiEOG779NZ3.
PhylomeDBiO17850.

Miscellaneous databases

NextBioi907892.
PROiO17850.

Family and domain databases

InterProiIPR006155. Josephin.
IPR003903. Ubiquitin-int_motif.
[Graphical view]
PfamiPF02099. Josephin. 1 hit.
PF02809. UIM. 2 hits.
[Graphical view]
PRINTSiPR01233. JOSEPHIN.
SMARTiSM00726. UIM. 2 hits.
[Graphical view]
PROSITEiPS50957. JOSEPHIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Structural modeling of ataxin-3 reveals distant homology to adaptins."
    Albrecht M., Hoffmann D., Evert B.O., Schmitt I., Wuellner U., Lengauer T.
    Proteins 50:355-370(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING.

Entry informationi

Entry nameiATX3_CAEEL
AccessioniPrimary (citable) accession number: O17850
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: January 1, 1998
Last modified: January 7, 2015
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.