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Protein

Pyruvate kinase

Gene

pyk-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 5 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase 2 (gpd-2), Glyceraldehyde-3-phosphate dehydrogenase 4 (gpd-4), Glyceraldehyde-3-phosphate dehydrogenase 3 (gpd-3), Glyceraldehyde-3-phosphate dehydrogenase 1 (gpd-1)
  2. Probable phosphoglycerate kinase (pgk-1)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (ipgm-1)
  4. Enolase (enol-1)
  5. Pyruvate kinase (pyk-1), Pyruvate kinase (pyk-1), Pyruvate kinase (pyk-2), Pyruvate kinase (pyk-2), Pyruvate kinase (pyk-1), Pyruvate kinase (pyk-2), Pyruvate kinase (pyk-1), Pyruvate kinase (pyk-1)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationImported, Transferase

Keywords - Biological processi

GlycolysisUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, PyruvateImported

Enzyme and pathway databases

ReactomeiR-CEL-70171. Glycolysis.
UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinaseUniRule annotation (EC:2.7.1.40UniRule annotation)
Gene namesi
Name:pyk-1Imported
ORF Names:CELE_F25H5.3Imported, F25H5.3Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiF25H5.3a; CE15898; WBGene00009126; pyk-1.

PTM / Processingi

Proteomic databases

EPDiO17836.
PaxDbiO17836.
PRIDEiO17836.

Expressioni

Gene expression databases

ExpressionAtlasiO17836. baseline.

Interactioni

Protein-protein interaction databases

DIPiDIP-25767N.
IntActiO17836. 2 interactions.
STRINGi6239.F25H5.3e.

Structurei

3D structure databases

ProteinModelPortaliO17836.
SMRiO17836. Positions 60-559.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini78 – 425348PKInterPro annotationAdd
BLAST
Domaini442 – 559118PK_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the pyruvate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2323. Eukaryota.
COG0469. LUCA.
GeneTreeiENSGT00390000008859.
HOGENOMiHOG000021559.
KOiK00873.

Family and domain databases

Gene3Di2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProiIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
PROSITEiPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O17836-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSQVQDVE LAEAGDTINE VKASSASGRG RLARRMTIEE EHAGDYFKQE
60 70 80 90 100
QKLAAVPATT HMEHLCRLDI REAPHLVRQT GIICTIGPAC ASVEMLQKLI
110 120 130 140 150
LNGMNIARLN FSHGSHEYHA GTIANVREAA DSFSDKRVIG IALDTKGPEI
160 170 180 190 200
RTGLLAGGAS AEIELARGAS IRLTTDPHFS ESGTAVNLFV DYKNIAKVLS
210 220 230 240 250
VGSRVYIDDG LISLIVEELQ TDAVICSVEN GGMLGSRKGV NLPGTIVDLP
260 270 280 290 300
AVSEKDCKDL QFGVEQGVDI IFASFIRNAE GIRTIRKVLG EKGKKIKIIA
310 320 330 340 350
KIENQEGVDN ADEIISESDG VMVARGDLGI EIPAEKVFLA QKMLISKCNR
360 370 380 390 400
AGKPVICATQ MLESMVHKPR PTRAEGSDVA NAVLDGADCV MLSGETAKGE
410 420 430 440 450
YPVDALKIMH YICKEAEAAV YHRRLFDELL QNTQKPTDMS HTIAIAATSA
460 470 480 490 500
AASCHASAIL LITTTGRSAI QCSRYKPAVP ILTISRDVAV CRQLHLYRGV
510 520 530 540 550
FPVHYPAERA ADWPTDVDNR INHAIAIGKD RGFIHKGDFL VVVTGWRQGA
560
GATNTLRIIT AE
Length:562
Mass (Da):60,664
Last modified:January 1, 1998 - v1
Checksum:i6865EC68BBCAD9A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CAB02984.1.
PIRiT21361.
RefSeqiNP_492458.1. NM_060057.4.
UniGeneiCel.17414.

Genome annotation databases

EnsemblMetazoaiF25H5.3a; F25H5.3a; WBGene00009126.
GeneIDi172744.
KEGGicel:CELE_F25H5.3.
UCSCiF25H5.3d. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CAB02984.1.
PIRiT21361.
RefSeqiNP_492458.1. NM_060057.4.
UniGeneiCel.17414.

3D structure databases

ProteinModelPortaliO17836.
SMRiO17836. Positions 60-559.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-25767N.
IntActiO17836. 2 interactions.
STRINGi6239.F25H5.3e.

Proteomic databases

EPDiO17836.
PaxDbiO17836.
PRIDEiO17836.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF25H5.3a; F25H5.3a; WBGene00009126.
GeneIDi172744.
KEGGicel:CELE_F25H5.3.
UCSCiF25H5.3d. c. elegans.

Organism-specific databases

CTDi172744.
WormBaseiF25H5.3a; CE15898; WBGene00009126; pyk-1.

Phylogenomic databases

eggNOGiKOG2323. Eukaryota.
COG0469. LUCA.
GeneTreeiENSGT00390000008859.
HOGENOMiHOG000021559.
KOiK00873.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00188.
ReactomeiR-CEL-70171. Glycolysis.

Gene expression databases

ExpressionAtlasiO17836. baseline.

Family and domain databases

Gene3Di2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProiIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
PROSITEiPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiO17836_CAEEL
AccessioniPrimary (citable) accession number: O17836
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: July 6, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.