Pyruvate kinase - Caenorhabditis elegans

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Unreviewed, UniProtKB/TrEMBL O17835 (O17835_CAEEL)

Last modified February 9, 2010. Version 76. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequences · References · Cross-references · Entry information

Names and origin

Protein names

Recommended name:
Pyruvate kinase RuleBase RU000504V4
EC=2.7.1.40 RuleBase RU000504V4

Gene names

Name:	pyk-1 EMBL CAB02983.1
ORF Names:	F25H5.3 WormBase WBGene00009126 WormPep F25H5.3b, F25H5.3B, F25H5.3b EMBL CAB02983.1

Organism

Caenorhabditis elegans [Complete proteome] EMBL CAB02983.1

Taxonomic identifier

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	600 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	ATP + pyruvate = ADP + phosphoenolpyruvate. RuleBase RU000504V4
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5. RuleBase RU000504V4
Sequence similarities	Belongs to the pyruvate kinase family.

Ontologies

Keywords
Biological process	Glycolysis RuleBase RU000504V4
Ligand	Magnesium RuleBase RU000504V4
Molecular function	Kinase RuleBase RU000504V4 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	embryonic development ending in birth or egg hatching Inferred from mutant phenotype. Source: WormBase glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW potassium ion binding Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: IntAct pyruvate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
nhr-111	O45521	1	EBI-320466,EBI-313236

Sequences

Sequence

Length

Mass (Da)

Tools

O17835-1 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: E03DE235AA9E633E
Show »

600

65,080

        10         20         30         40         50         60 
MYRFWSLISG DKVISKTSMK SIENAKHIAH VEQVPLSPML SKLIGEPPAL DENNNEKIGG 

        70         80         90        100        110        120 
SCSDENRPKT HVCSVPGFMQ KPYKTRQEQK LAAVPATTHM EHLCRLDIRE APHLVRQTGI 

       130        140        150        160        170        180 
ICTIGPACAS VEMLQKLILN GMNIARLNFS HGSHEYHAGT IANVREAADS FSDKRVIGIA 

       190        200        210        220        230        240 
LDTKGPEIRT GLLAGGASAE IELARGASIR LTTDPHFSES GTAVNLFVDY KNIAKVLSVG 

       250        260        270        280        290        300 
SRVYIDDGLI SLIVEELQTD AVICSVENGG MLGSRKGVNL PGTIVDLPAV SEKDCKDLQF 

       310        320        330        340        350        360 
GVEQGVDIIF ASFIRNAEGI RTIRKVLGEK GKKIKIIAKI ENQEGVDNAD EIISESDGVM 

       370        380        390        400        410        420 
VARGDLGIEI PAEKVFLAQK MLISKCNRAG KPVICATQML ESMVHKPRPT RAEGSDVANA 

       430        440        450        460        470        480 
VLDGADCVML SGETAKGEYP VDALKIMHYI CKEAEAAVYH RRLFDELLQN TQKPTDMSHT 

       490        500        510        520        530        540 
IAIAATSAAA SCHASAILLI TTTGRSAIQC SRYKPAVPIL TISRDVAVCR QLHLYRGVFP 

       550        560        570        580        590        600 
VHYPAERAAD WPTDVDNRIN HAIAIGKDRG FIHKGDFLVV VTGWRQGAGA TNTLRIITAE

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z81068 Genomic DNA. Translation: CAB02983.1.
PIR	T21360.
RefSeq	NP_492459.1.
UniGene	Cel.17414
3D structure databases
HSSP	HSSP built from PDB template 1LIY based on UniProtKB P30613.
SMR	O17835. Positions 87-597.
ModBase	Search...
Protein-protein interaction databases
IntAct	O17835. 4 interactions.
STRING	O17835.
Proteomic databases
PRIDE	O17835.
Genome annotation databases
Ensembl	F25H5.3b; F25H5.3b; F25H5.3; Caenorhabditis elegans. [Genome view]
GeneID	172744.
UCSC	F25H5.3d. c. elegans.
Organism-specific databases
CTD	172744.
WormBase	WBGene00009126. F25H5.3.
WormPep	F25H5.3b. CE15899. [WorfDB]
Phylogenomic databases
eggNOG	meNOG07045.
OMA	DEICSTA.
PhylomeDB	O17835.
Gene expression databases
ArrayExpress	O17835.
Family and domain databases
InterPro	IPR001697. Pyr_Knase. IPR015813. Pyrv/PenolPyrv_Kinase_cat. IPR015794. Pyrv_Knase_a/b. IPR018209. Pyrv_Knase_AS. IPR011037. Pyrv_Knase_b-brl-like. IPR015793. Pyrv_Knase_brl. IPR015795. Pyrv_Knase_C-like. [Graphical view]
Gene3D	G3DSA:3.20.20.60. Pyrv/PenolPyrv_Kinase_cat. 1 hit. G3DSA:3.40.1380.20. Pyrv_Knase_a/b. 1 hit.
PANTHER	PTHR11817. Pyruvate_kinase. 1 hit.
Pfam	PF00224. PK. 1 hit. PF02887. PK_C. 1 hit. [Graphical view]
PRINTS	PR01050. PYRUVTKNASE.
TIGRFAMs	TIGR01064. pyruv_kin. 1 hit.
PROSITE	PS00110. PYRUVATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	876831.

Entry information

Entry name

O17835_CAEEL

Accession

Primary (citable) accession number: O17835

Entry history

Integrated into UniProtKB/TrEMBL:	January 1, 1998
Last sequence update:	January 1, 1998
Last modified:	February 9, 2010
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequences · References · Cross-references · Entry information