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Protein

Pyruvate kinase

Gene

pyk-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 5 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase 2 (gpd-2), Glyceraldehyde-3-phosphate dehydrogenase 4 (gpd-4), Glyceraldehyde-3-phosphate dehydrogenase 3 (gpd-3), Glyceraldehyde-3-phosphate dehydrogenase 1 (gpd-1)
  2. Probable phosphoglycerate kinase (pgk-1)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (ipgm-1)
  4. Enolase (enol-1)
  5. Pyruvate kinase (pyk-1), Pyruvate kinase (pyk-1), Pyruvate kinase (pyk-2), Pyruvate kinase (pyk-2), Pyruvate kinase (pyk-1), Pyruvate kinase (pyk-2), Pyruvate kinase (pyk-1), Pyruvate kinase (pyk-1)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationImported, Transferase

Keywords - Biological processi

GlycolysisUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, PyruvateImported

Enzyme and pathway databases

ReactomeiR-CEL-70171. Glycolysis.
UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinaseUniRule annotation (EC:2.7.1.40UniRule annotation)
Gene namesi
Name:pyk-1Imported
ORF Names:CELE_F25H5.3Imported, F25H5.3Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiF25H5.3b; CE15899; WBGene00009126; pyk-1.

PTM / Processingi

Proteomic databases

EPDiO17835.
PaxDbiO17835.
PRIDEiO17835.

Expressioni

Gene expression databases

BgeeiWBGene00009126.
ExpressionAtlasiO17835. baseline.

Interactioni

Protein-protein interaction databases

IntActiO17835. 2 interactions.
MINTiMINT-1040211.
STRINGi6239.F25H5.3e.

Structurei

3D structure databases

ProteinModelPortaliO17835.
SMRiO17835. Positions 98-597.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini116 – 463348PKInterPro annotationAdd
BLAST
Domaini480 – 597118PK_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the pyruvate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2323. Eukaryota.
COG0469. LUCA.
GeneTreeiENSGT00390000008859.
HOGENOMiHOG000021559.
OMAiNSIDMIA.
PhylomeDBiO17835.

Family and domain databases

Gene3Di2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProiIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
PROSITEiPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O17835-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRFWSLISG DKVISKTSMK SIENAKHIAH VEQVPLSPML SKLIGEPPAL
60 70 80 90 100
DENNNEKIGG SCSDENRPKT HVCSVPGFMQ KPYKTRQEQK LAAVPATTHM
110 120 130 140 150
EHLCRLDIRE APHLVRQTGI ICTIGPACAS VEMLQKLILN GMNIARLNFS
160 170 180 190 200
HGSHEYHAGT IANVREAADS FSDKRVIGIA LDTKGPEIRT GLLAGGASAE
210 220 230 240 250
IELARGASIR LTTDPHFSES GTAVNLFVDY KNIAKVLSVG SRVYIDDGLI
260 270 280 290 300
SLIVEELQTD AVICSVENGG MLGSRKGVNL PGTIVDLPAV SEKDCKDLQF
310 320 330 340 350
GVEQGVDIIF ASFIRNAEGI RTIRKVLGEK GKKIKIIAKI ENQEGVDNAD
360 370 380 390 400
EIISESDGVM VARGDLGIEI PAEKVFLAQK MLISKCNRAG KPVICATQML
410 420 430 440 450
ESMVHKPRPT RAEGSDVANA VLDGADCVML SGETAKGEYP VDALKIMHYI
460 470 480 490 500
CKEAEAAVYH RRLFDELLQN TQKPTDMSHT IAIAATSAAA SCHASAILLI
510 520 530 540 550
TTTGRSAIQC SRYKPAVPIL TISRDVAVCR QLHLYRGVFP VHYPAERAAD
560 570 580 590 600
WPTDVDNRIN HAIAIGKDRG FIHKGDFLVV VTGWRQGAGA TNTLRIITAE
Length:600
Mass (Da):65,080
Last modified:January 1, 1998 - v1
Checksum:iE03DE235AA9E633E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CAB02983.1.
PIRiT21360.
RefSeqiNP_492459.1. NM_060058.3.
UniGeneiCel.17414.

Genome annotation databases

EnsemblMetazoaiF25H5.3b; F25H5.3b; WBGene00009126.
GeneIDi172744.
UCSCiF25H5.3d. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CAB02983.1.
PIRiT21360.
RefSeqiNP_492459.1. NM_060058.3.
UniGeneiCel.17414.

3D structure databases

ProteinModelPortaliO17835.
SMRiO17835. Positions 98-597.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO17835. 2 interactions.
MINTiMINT-1040211.
STRINGi6239.F25H5.3e.

Proteomic databases

EPDiO17835.
PaxDbiO17835.
PRIDEiO17835.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF25H5.3b; F25H5.3b; WBGene00009126.
GeneIDi172744.
UCSCiF25H5.3d. c. elegans.

Organism-specific databases

CTDi172744.
WormBaseiF25H5.3b; CE15899; WBGene00009126; pyk-1.

Phylogenomic databases

eggNOGiKOG2323. Eukaryota.
COG0469. LUCA.
GeneTreeiENSGT00390000008859.
HOGENOMiHOG000021559.
OMAiNSIDMIA.
PhylomeDBiO17835.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00188.
ReactomeiR-CEL-70171. Glycolysis.

Gene expression databases

BgeeiWBGene00009126.
ExpressionAtlasiO17835. baseline.

Family and domain databases

Gene3Di2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProiIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
PROSITEiPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO17835_CAEEL
AccessioniPrimary (citable) accession number: O17835
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.