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Protein

Furin-like protease kpc-1

Gene

kpc-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Furin-like protease which regulates dendritic branching of FLP and PVD sensory neurons. Also regulates dauer-specific dendritic branching of IL2 neurons and dauer-specific nictation behavior.1 Publication

Cofactori

Ca2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi176 – 1761Calcium 1By similarity
Active sitei221 – 2211Charge relay systemBy similarity
Metal bindingi230 – 2301Calcium 1By similarity
Active sitei262 – 2621Charge relay systemBy similarity
Metal bindingi276 – 2761Calcium 1By similarity
Metal bindingi326 – 3261Calcium 2By similarity
Metal bindingi369 – 3691Calcium 2By similarity
Metal bindingi399 – 3991Calcium 2By similarity
Active sitei436 – 4361Charge relay systemBy similarity

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • serine-type endopeptidase activity Source: WormBase

GO - Biological processi

  • dendrite morphogenesis Source: WormBase
  • insulin processing Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

SignaLinkiO17798.

Protein family/group databases

MEROPSiS08.047.

Names & Taxonomyi

Protein namesi
Recommended name:
Furin-like protease kpc-11 Publication (EC:3.4.21.-)
Gene namesi
Name:kpc-1Imported
ORF Names:F11A6.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiF11A6.1a; CE17653; WBGene00002232; kpc-1.
F11A6.1b; CE17654; WBGene00002232; kpc-1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei739 – 75921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • axon Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • neuronal cell body Source: WormBase
  • perikaryon Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi440 – 4401P → L in my24; highly disorganized and truncated dauer-specific branching of the IL2Q neuron and disorganized and truncated branching of the PVD and FLP neurons in adults. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence analysisAdd
BLAST
Propeptidei34 – 139106Sequence analysisBy similarityPRO_0000430490Add
BLAST
Chaini140 – 760621Furin-like protease kpc-1By similarityPRO_0000430491Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi275 – 2751N-linked (GlcNAc...)Sequence analysis
Disulfide bondi279 ↔ 428By similarity
Disulfide bondi371 ↔ 401By similarity
Glycosylationi455 – 4551N-linked (GlcNAc...)Sequence analysis
Glycosylationi487 – 4871N-linked (GlcNAc...)Sequence analysis
Disulfide bondi518 ↔ 612By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

EPDiO17798.
PaxDbiO17798.

Expressioni

Tissue specificityi

Expressed broadly in neuronal and epithelial cells throughout the head during the dauer stage. Expressed in the ventral nerve cord and pharynx with strong expression in the g2 pharyngeal gland cells and vpi pharyngeal intestinal valve cells of non-dauer animals. Expressed in the IL2 neurons during dauer but not during non-dauer stages.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi6239.F11A6.1b.

Structurei

3D structure databases

ProteinModelPortaliO17798.
SMRiO17798. Positions 171-518, 600-711.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini216 – 503288Peptidase S8Sequence analysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi638 – 6403Cell attachment siteBy similarity

Sequence similaritiesi

Belongs to the peptidase S8 family. Furin subfamily.Sequence analysis
Contains 1 peptidase S8 domain.Sequence analysis

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3525. Eukaryota.
COG1404. LUCA.
COG4935. LUCA.
HOGENOMiHOG000192536.
InParanoidiO17798.
KOiK01349.
OMAiSSICTTH.
OrthoDBiEOG7BW0JD.
PhylomeDBiO17798.

Family and domain databases

Gene3Di2.60.120.260. 2 hits.
3.30.70.850. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Propept_inh.
IPR002884. PrprotnconvertsP.
IPR032815. S8_pro-domain.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 4 hits.
PfamiPF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
PF16470. S8_pro-domain. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform b1 Publication (identifier: O17798-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSNISWYRHC SVRLQLVTLA LFLLLGSASL GSAHIDEEFE DDVTTTISSI
60 70 80 90 100
ASPMRRTYTN EWAVRIAGGK VEEANRLANK YGYTNLGPII PGDEYYLFRD
110 120 130 140 150
DRKKSRSSRK TRSLSANQLQ HEEDVMWMEQ QVAKRRVKRG YRRIRRHTDD
160 170 180 190 200
NDIFEEDDDG TQISKSRNRK HPDPNDPLWT DMWYLNRGEH HSDSTTRMDH
210 220 230 240 250
NVKEAWDLGY TGKGVVVTIL DDGLERTHPD ISPNYDERAS YDVNDRDNDP
260 270 280 290 300
MPRYEFSDEN RHGTRCAGEV AAIFNNSLCI VGIAYNANIG GIRMLDGDVT
310 320 330 340 350
DAVEAASVGH NADYIDIYSA SWGPDDDGRT VDGPAKLTRS AFEKGITMGR
360 370 380 390 400
KGKGSIFVWA SGNGGKDADS CNCDGYTNSI YTLSISSATE NGNIPWYSEA
410 420 430 440 450
CSSTLATTYS SGATGEKMIL TTDLHHACTN MHTGTSASAP LAAGIVALAL
460 470 480 490 500
EANPNLTWRD LQHIVIRTAK PINLRAGDWT TNGVGRNVSH SFGYGLMDAG
510 520 530 540 550
AMVKLAKIWK KVDEQHRCRQ FYPSRYKRFS NLPEVYRSLQ KFPKISRFFQ
560 570 580 590 600
KFLEVSEVHT IFQKFPGTST RFQKFPKILE IEKMFRNSKK LQVFRNIPNG
610 620 630 640 650
NRLQLQLYSD GCYGGADENK VSYVEHVQAI VTLKAPKRGD LQIYLTSPSG
660 670 680 690 700
TKSTLLTKRA RDTSRSGFTD WAFMTTHNWG EQAAGLWILE IDNDGWDDAE
710 720 730 740 750
LVKWELVLYG TDRETGDFGG QHASPLAVRS VQMEATSSGT QYSIFHVITL
760
VILTFSQILY
Note: No experimental confirmation available.Curated
Length:760
Mass (Da):85,467
Last modified:August 1, 1998 - v2
Checksum:i1AC28B3A9103291C
GO
Isoform a1 Publication (identifier: O17798-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     528-595: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:692
Mass (Da):77,125
Checksum:iB5F17DDF22BA3311
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei528 – 59568Missing in isoform a. 1 PublicationVSP_056769Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81498 Genomic DNA. Translation: CAB04085.1.
Z81498 Genomic DNA. Translation: CAB04086.1.
PIRiT20759.
T20760.
RefSeqiNP_492974.2. NM_060573.5. [O17798-2]
UniGeneiCel.22630.

Genome annotation databases

GeneIDi173051.
KEGGicel:CELE_F11A6.1.
UCSCiF11A6.1a.2. c. elegans. [O17798-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81498 Genomic DNA. Translation: CAB04085.1.
Z81498 Genomic DNA. Translation: CAB04086.1.
PIRiT20759.
T20760.
RefSeqiNP_492974.2. NM_060573.5. [O17798-2]
UniGeneiCel.22630.

3D structure databases

ProteinModelPortaliO17798.
SMRiO17798. Positions 171-518, 600-711.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F11A6.1b.

Protein family/group databases

MEROPSiS08.047.

Proteomic databases

EPDiO17798.
PaxDbiO17798.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi173051.
KEGGicel:CELE_F11A6.1.
UCSCiF11A6.1a.2. c. elegans. [O17798-1]

Organism-specific databases

CTDi173051.
WormBaseiF11A6.1a; CE17653; WBGene00002232; kpc-1.
F11A6.1b; CE17654; WBGene00002232; kpc-1.

Phylogenomic databases

eggNOGiKOG3525. Eukaryota.
COG1404. LUCA.
COG4935. LUCA.
HOGENOMiHOG000192536.
InParanoidiO17798.
KOiK01349.
OMAiSSICTTH.
OrthoDBiEOG7BW0JD.
PhylomeDBiO17798.

Enzyme and pathway databases

SignaLinkiO17798.

Miscellaneous databases

PROiO17798.

Family and domain databases

Gene3Di2.60.120.260. 2 hits.
3.30.70.850. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Propept_inh.
IPR002884. PrprotnconvertsP.
IPR032815. S8_pro-domain.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 4 hits.
PfamiPF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
PF16470. S8_pro-domain. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2Imported.
  2. "Dauer-specific dendrite arborization in C. elegans is regulated by KPC-1/Furin."
    Schroeder N.E., Androwski R.J., Rashid A., Lee H., Lee J., Barr M.M.
    Curr. Biol. 23:1527-1535(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF PRO-440.
    Strain: Bristol N21 Publication.

Entry informationi

Entry nameiFKPC1_CAEEL
AccessioniPrimary (citable) accession number: O17798
Secondary accession number(s): O17797
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 2014
Last sequence update: August 1, 1998
Last modified: July 6, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.