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Protein
Submitted name:

Uncharacterized protein

Gene

egl-21

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • carboxypeptidase activity Source: WormBase
  • metallocarboxypeptidase activity Source: GO_Central
  • serine-type carboxypeptidase activity Source: GO_Central
  • zinc ion binding Source: InterPro

GO - Biological processi

  • acetylcholine secretion, neurotransmission Source: WormBase
  • larval feeding behavior Source: UniProtKB
  • peptide metabolic process Source: GO_Central
  • protein processing Source: WormBase
  • regulation of eating behavior Source: UniProtKB
Complete GO annotation...

Protein family/group databases

MEROPSiM14.033.

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:egl-21Imported
ORF Names:CELE_F01D4.4Imported, F01D4.4Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiF01D4.4; CE09156; WBGene00001189; egl-21.

Subcellular locationi

GO - Cellular componenti

  • axon Source: WormBase
  • cytoplasmic vesicle Source: WormBase
  • extracellular space Source: GO_Central
  • neuronal cell body Source: WormBase
  • presynapse Source: GOC
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_500415741122 – 472Sequence analysisAdd BLAST451

Proteomic databases

EPDiO17754.
PaxDbiO17754.
PeptideAtlasiO17754.

Expressioni

Gene expression databases

BgeeiWBGene00001189.

Interactioni

Protein-protein interaction databases

DIPiDIP-26452N.
IntActiO17754. 1 interactor.
MINTiMINT-1076769.
STRINGi6239.F01D4.4.1.

Structurei

3D structure databases

ProteinModelPortaliO17754.
SMRiO17754.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini92 – 114Peptidase_M14InterPro annotationAdd BLAST23

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG2649. Eukaryota.
ENOG410XX0H. LUCA.
GeneTreeiENSGT00760000119124.
HOGENOMiHOG000232185.
InParanoidiO17754.
KOiK01294.
OMAiINLIHNT.
OrthoDBiEOG091G06A9.
PhylomeDBiO17754.

Family and domain databases

Gene3Di2.60.40.1120. 1 hit.
InterProiIPR008969. CarboxyPept-like_regulatory.
IPR014766. CarboxyPept_regulatory_dom.
IPR000834. Peptidase_M14.
[Graphical view]
PfamiPF00246. Peptidase_M14. 1 hit.
[Graphical view]
PRINTSiPR00765. CRBOXYPTASEA.
SMARTiSM00631. Zn_pept. 1 hit.
[Graphical view]
SUPFAMiSSF49464. SSF49464. 1 hit.
PROSITEiPS00132. CARBOXYPEPT_ZN_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O17754-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLHAMRPVLL VAALLAVTAH AFLGFGSGST HKDDAEWGHY HNQAQLEAKL
60 70 80 90 100
GEINEKCPEI TTLYEIGQSV EGRPLVVIQF STTPGEHIPT KPEVKLIGNM
110 120 130 140 150
HGNEPIGREL LLRFAETLCN GAINNDKEIV QLLNSTSIHI LPSMNPDGFE
160 170 180 190 200
LALGTEPAQR QWLTGRSNIN GVDLNRDFPD LDSIFYELQK IGVPKFDHLL
210 220 230 240 250
SLFEDNVDRQ PETIAVGQWT LSLPFVLSAN FHEGDLVANY PFDAAIDENS
260 270 280 290 300
QKTAYSASPD DGTFRWLAKS YADNHAHMSK NDHAPCDGTS QDAFARQGGI
310 320 330 340 350
TNGAKWYSVA GGMQDFNYLA TNAMEITLEL SCEKMPEGSQ LPRFWEDNQK
360 370 380 390 400
SIFEYVWKSH SGVKGMVVDA MTGEPIKRAV VWIRNGTETV PVKHPVTTWS
410 420 430 440 450
EGDFYRVLPA GKYEIIVAAE GYDIAAKNVT VENKVRDSAL VVNFALSPAA
460 470
DEPSENEQEQ IAELVNEIAR RR
Length:472
Mass (Da):52,279
Last modified:January 1, 1998 - v1
Checksum:iE3B1AFF682075A8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CAB02881.1.
PIRiT20454.
RefSeqiNP_501935.1. NM_069534.6.
UniGeneiCel.17657.

Genome annotation databases

EnsemblMetazoaiF01D4.4.1; F01D4.4.1; WBGene00001189.
F01D4.4.2; F01D4.4.2; WBGene00001189.
F01D4.4.3; F01D4.4.3; WBGene00001189.
GeneIDi177940.
KEGGicel:CELE_F01D4.4.
UCSCiF01D4.4.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CAB02881.1.
PIRiT20454.
RefSeqiNP_501935.1. NM_069534.6.
UniGeneiCel.17657.

3D structure databases

ProteinModelPortaliO17754.
SMRiO17754.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-26452N.
IntActiO17754. 1 interactor.
MINTiMINT-1076769.
STRINGi6239.F01D4.4.1.

Protein family/group databases

MEROPSiM14.033.

Proteomic databases

EPDiO17754.
PaxDbiO17754.
PeptideAtlasiO17754.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF01D4.4.1; F01D4.4.1; WBGene00001189.
F01D4.4.2; F01D4.4.2; WBGene00001189.
F01D4.4.3; F01D4.4.3; WBGene00001189.
GeneIDi177940.
KEGGicel:CELE_F01D4.4.
UCSCiF01D4.4.1. c. elegans.

Organism-specific databases

CTDi177940.
WormBaseiF01D4.4; CE09156; WBGene00001189; egl-21.

Phylogenomic databases

eggNOGiKOG2649. Eukaryota.
ENOG410XX0H. LUCA.
GeneTreeiENSGT00760000119124.
HOGENOMiHOG000232185.
InParanoidiO17754.
KOiK01294.
OMAiINLIHNT.
OrthoDBiEOG091G06A9.
PhylomeDBiO17754.

Gene expression databases

BgeeiWBGene00001189.

Family and domain databases

Gene3Di2.60.40.1120. 1 hit.
InterProiIPR008969. CarboxyPept-like_regulatory.
IPR014766. CarboxyPept_regulatory_dom.
IPR000834. Peptidase_M14.
[Graphical view]
PfamiPF00246. Peptidase_M14. 1 hit.
[Graphical view]
PRINTSiPR00765. CRBOXYPTASEA.
SMARTiSM00631. Zn_pept. 1 hit.
[Graphical view]
SUPFAMiSSF49464. SSF49464. 1 hit.
PROSITEiPS00132. CARBOXYPEPT_ZN_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO17754_CAEEL
AccessioniPrimary (citable) accession number: O17754
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.