Reviewed,
UniProtKB/Swiss-Prot O17695 (HDA1_CAEEL)
Last modified
November 3, 2009.
Version 72.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Histone deacetylase 1 EC=3.5.1.98 | ||||
| Gene names |
| ||||
| Organism | Caenorhabditis elegans [Complete proteome] | ||||
| Taxonomic identifier | 6239 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Protein attributes
| Sequence length | 461 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in the endoderm determination possibly by repressing end-1 expression. Also involved in vulval development, possibly by repressing lag-2 expression. Ref.2 Ref.3 |
| Catalytic activity | Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone. |
| Subunit structure | Interacts with pop-1. Ref.2 |
| Subcellular location | Nucleus. Cytoplasm. Note: Except in the germ line where it is also cytoplasmic. |
| Tissue specificity | Ubiquitously expressed throughout embryonic and postembryonic development. Ref.3 |
| Developmental stage | Expressed both maternally and zygotically. Ref.3 |
| Post-translational modification | Sumoylated Probable. |
| Sequence similarities | Belongs to the histone deacetylase family. Type 1 subfamily. |
Ontologies
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| lin-35 | O01682 | 1 | EBI-318045,EBI-321470 | |
| lin-53 | P90916 | 1 | EBI-318045,EBI-324314 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 461 | 461 | Histone deacetylase 1 | PRO_0000114719 | |||||
Regions | |||||||||
| Region | 13 – 325 | 313 | Histone deacetylase | ||||||
Sites | |||||||||
| Active site | 145 | 1 | By similarity | ||||||
Experimental info | |||||||||
| Mutagenesis | 145 | 1 | H → F: Loss of function. | ||||||
| Mutagenesis | 186 | 1 | G → E in gon-10; specific defects in gonadogenesis and vulval development. Ref.3 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2. |
| [2] | "A POP-1 repressor complex restricts inappropriate cell type-specific gene transcription during Caenorhabditis elegans embryogenesis." Calvo D., Victor M., Gay F., Sui G., Luke M.P.-S., Dufourcq P., Wen G., Maduro M., Rothman J., Shi Y. EMBO J. 20:7197-7208(2001) [PubMed: 11742996] [Abstract] Cited for: FUNCTION, INTERACTION WITH POP-1. |
| [3] | "Functional requirement for histone deacetylase 1 in Caenorhabditis elegans gonadogenesis." Dufourcq P., Victor M., Gay F., Calvo D., Hodgkin J., Shi Y. Mol. Cell. Biol. 22:3024-3034(2002) [PubMed: 11940660] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, MUTAGENESIS OF GLY-186. |
| [4] | "Chromatin regulation and sumoylation in the inhibition of Ras-induced vulval development in Caenorhabditis elegans." Poulin G., Dong Y., Fraser A.G., Hopper N.A., Ahringer J. EMBO J. 24:2613-2623(2005) [PubMed: 15990876] [Abstract] Cited for: SUMOYLATION. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| Z81486 Genomic DNA. Translation: CAB03984.1. | |
| PIR | T20163. |
| RefSeq | NP_506599.1. |
| UniGene | Cel.17341 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1C3P based on UniProtKB O67135. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:26427N. |
| IntAct | O17695. 10 interactions. |
| STRING | O17695. |
Genome annotation databases | |
| Ensembl | C53A5.3.1; C53A5.3.1; C53A5.3; Caenorhabditis elegans. [Genome view] C53A5.3.2; C53A5.3.2; C53A5.3; Caenorhabditis elegans. [Genome view] |
| GeneID | 179959. |
| KEGG | cel:C53A5.3. |
| UCSC | C53A5.3.1. c. elegans. |
Organism-specific databases | |
| CTD | 179959. |
| WormBase | WBGene00001834. hda-1. |
| WormPep | C53A5.3. CE08952. [WorfDB] |
Phylogenomic databases | |
| OMA | GECARFF. |
Gene expression databases | |
| ArrayExpress | O17695. |
Family and domain databases | |
| InterPro | IPR000286. His_deacetylse. IPR003084. His_deacetylse_1. [Graphical view] |
| Gene3D | G3DSA:3.40.800.20. His_deacetylse. 1 hit. |
| PANTHER | PTHR10625. His_deacetylse. 1 hit. PTHR10625:SF28. His_deacetylse_1. 1 hit. |
| Pfam | PF00850. Hist_deacetyl. 1 hit. [Graphical view] |
| PIRSF | PIRSF037913. His_deacetylse_1. 1 hit. |
| PRINTS | PR01270. HDASUPER. PR01271. HISDACETLASE. |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 907546. |
Entry information
| Entry name | HDA1_CAEEL | ||||||||
| Accession | Primary (citable) accession number: O17695 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Caenorhabditis annotation project | ||||||||
Relevant documents
| Caenorhabditis elegans Caenorhabditis elegans: entries, gene names and cross-references to WormPep |
| SIMILARITY comments Index of protein domains and families |

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