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O17695

- HDA1_CAEEL

UniProt

O17695 - HDA1_CAEEL

Protein

Histone deacetylase 1

Gene

hda-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in the endoderm determination possibly by repressing end-1 expression. Also involved in vulval development, possibly by repressing lag-2 expression.2 Publications

    Catalytic activityi

    Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei145 – 1451By similarity

    GO - Molecular functioni

    1. histone deacetylase activity Source: WormBase
    2. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
    3. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
    4. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
    5. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC
    6. protein binding Source: UniProtKB

    GO - Biological processi

    1. embryo development ending in birth or egg hatching Source: WormBase
    2. embryonic digestive tract morphogenesis Source: WormBase
    3. gonad development Source: WormBase
    4. histone deacetylation Source: WormBase
    5. negative regulation of Notch signaling pathway Source: WormBase
    6. negative regulation of Ras protein signal transduction Source: WormBase
    7. negative regulation of transcription from RNA polymerase II promoter Source: WormBase
    8. negative regulation of vulval development Source: WormBase
    9. nematode male tail tip morphogenesis Source: WormBase
    10. positive regulation of transcription from RNA polymerase II promoter Source: WormBase
    11. regulation of cell differentiation Source: WormBase
    12. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Developmental protein, Hydrolase, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone deacetylase 1 (EC:3.5.1.98)
    Gene namesi
    Name:hda-1
    ORF Names:C53A5.3
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome V

    Organism-specific databases

    WormBaseiC53A5.3; CE08952; WBGene00001834; hda-1.

    Subcellular locationi

    Nucleus. Cytoplasm
    Note: Except in the germ line where it is also cytoplasmic.

    GO - Cellular componenti

    1. cytoplasm Source: WormBase
    2. germ cell nucleus Source: WormBase
    3. histone deacetylase complex Source: WormBase
    4. nucleus Source: WormBase
    5. NuRD complex Source: WormBase

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi145 – 1451H → F: Loss of function.
    Mutagenesisi186 – 1861G → E in gon-10; specific defects in gonadogenesis and vulval development. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 461461Histone deacetylase 1PRO_0000114719Add
    BLAST

    Post-translational modificationi

    Sumoylated.1 Publication

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    PaxDbiO17695.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed throughout embryonic and postembryonic development.1 Publication

    Developmental stagei

    Expressed both maternally and zygotically.1 Publication

    Interactioni

    Subunit structurei

    Interacts with pop-1.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    pie-1Q941313EBI-318045,EBI-300501
    pop-1Q106663EBI-318045,EBI-317870

    Protein-protein interaction databases

    BioGridi44961. 22 interactions.
    DIPiDIP-26427N.
    IntActiO17695. 11 interactions.
    MINTiMINT-226391.
    STRINGi6239.C53A5.3.2.

    Structurei

    3D structure databases

    ProteinModelPortaliO17695.
    SMRiO17695. Positions 12-377.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni13 – 325313Histone deacetylaseAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0123.
    GeneTreeiENSGT00530000062889.
    HOGENOMiHOG000225180.
    InParanoidiO17695.
    KOiK06067.
    OMAiQIQPDNE.
    PhylomeDBiO17695.

    Family and domain databases

    Gene3Di3.40.800.20. 1 hit.
    InterProiIPR000286. His_deacetylse.
    IPR003084. His_deacetylse_1.
    IPR023801. His_deacetylse_dom.
    [Graphical view]
    PANTHERiPTHR10625. PTHR10625. 1 hit.
    PfamiPF00850. Hist_deacetyl. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
    PRINTSiPR01270. HDASUPER.
    PR01271. HISDACETLASE.

    Sequencei

    Sequence statusi: Complete.

    O17695-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSNGPLMEH GKRRVAYYYD SNIGNYYYGQ GHVMKPHRIR MTHHLVLNYG    50
    LYRNLEIFRP FPASFEDMTR FHSDEYMTFL KSANPDNLKS FNKQMLKFNV 100
    GEDCPLFDGL YEFCQLSSGG SLAAATKLNK QKVDIAINWM GGLHHAKKSE 150
    ASGFCYTNDI VLGILELLKY HKRVLYVDID VHHGDGVEEA FYTTDRVMTV 200
    SFHKYGDFFP GTGDLKDIGA GKGKLYSVNV PLRDGITDVS YQSIFKPIMT 250
    KVMERFDPCA VVLQCGADSL NGDRLGPFNL TLKGHGECAR FFRSYNVPLM 300
    MVGGGGYTPR NVARCWTYET SIAVDKEVPN ELPYNDYFEY FGPNYRLHIE 350
    SSNAANENSS DMLAKLQTDV IANLEQLTFV PSVQMRPIPE DALSALNDDS 400
    LIADQANPDK RLPPQITDGM IQDDGDFYDG EREGDDRRNE SDAKRAAQFE 450
    SEGGEKRQKT E 461
    Length:461
    Mass (Da):52,138
    Last modified:January 1, 1998 - v1
    Checksum:i9A104E88C5A1C07A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z81486 Genomic DNA. Translation: CAB03984.1.
    PIRiT20163.
    RefSeqiNP_506599.1. NM_074198.7.
    UniGeneiCel.17341.

    Genome annotation databases

    EnsemblMetazoaiC53A5.3; C53A5.3; WBGene00001834.
    GeneIDi179959.
    KEGGicel:CELE_C53A5.3.
    UCSCiC53A5.3.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z81486 Genomic DNA. Translation: CAB03984.1 .
    PIRi T20163.
    RefSeqi NP_506599.1. NM_074198.7.
    UniGenei Cel.17341.

    3D structure databases

    ProteinModelPortali O17695.
    SMRi O17695. Positions 12-377.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 44961. 22 interactions.
    DIPi DIP-26427N.
    IntActi O17695. 11 interactions.
    MINTi MINT-226391.
    STRINGi 6239.C53A5.3.2.

    Proteomic databases

    PaxDbi O17695.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai C53A5.3 ; C53A5.3 ; WBGene00001834 .
    GeneIDi 179959.
    KEGGi cel:CELE_C53A5.3.
    UCSCi C53A5.3.1. c. elegans.

    Organism-specific databases

    CTDi 179959.
    WormBasei C53A5.3 ; CE08952 ; WBGene00001834 ; hda-1.

    Phylogenomic databases

    eggNOGi COG0123.
    GeneTreei ENSGT00530000062889.
    HOGENOMi HOG000225180.
    InParanoidi O17695.
    KOi K06067.
    OMAi QIQPDNE.
    PhylomeDBi O17695.

    Miscellaneous databases

    NextBioi 907546.

    Family and domain databases

    Gene3Di 3.40.800.20. 1 hit.
    InterProi IPR000286. His_deacetylse.
    IPR003084. His_deacetylse_1.
    IPR023801. His_deacetylse_dom.
    [Graphical view ]
    PANTHERi PTHR10625. PTHR10625. 1 hit.
    Pfami PF00850. Hist_deacetyl. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037913. His_deacetylse_1. 1 hit.
    PRINTSi PR01270. HDASUPER.
    PR01271. HISDACETLASE.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    2. "A POP-1 repressor complex restricts inappropriate cell type-specific gene transcription during Caenorhabditis elegans embryogenesis."
      Calvo D., Victor M., Gay F., Sui G., Luke M.P.-S., Dufourcq P., Wen G., Maduro M., Rothman J., Shi Y.
      EMBO J. 20:7197-7208(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH POP-1.
    3. "Functional requirement for histone deacetylase 1 in Caenorhabditis elegans gonadogenesis."
      Dufourcq P., Victor M., Gay F., Calvo D., Hodgkin J., Shi Y.
      Mol. Cell. Biol. 22:3024-3034(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, MUTAGENESIS OF GLY-186.
    4. "Chromatin regulation and sumoylation in the inhibition of Ras-induced vulval development in Caenorhabditis elegans."
      Poulin G., Dong Y., Fraser A.G., Hopper N.A., Ahringer J.
      EMBO J. 24:2613-2623(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUMOYLATION.

    Entry informationi

    Entry nameiHDA1_CAEEL
    AccessioniPrimary (citable) accession number: O17695
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3