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O17695

- HDA1_CAEEL

UniProt

O17695 - HDA1_CAEEL

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Protein

Histone deacetylase 1

Gene

hda-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in the endoderm determination possibly by repressing end-1 expression. Also involved in vulval development, possibly by repressing lag-2 expression.2 Publications

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei145 – 1451By similarity

GO - Molecular functioni

  1. histone deacetylase activity Source: WormBase
  2. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  5. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC

GO - Biological processi

  1. embryo development ending in birth or egg hatching Source: WormBase
  2. embryonic digestive tract morphogenesis Source: WormBase
  3. gonad development Source: WormBase
  4. histone deacetylation Source: WormBase
  5. negative regulation of Notch signaling pathway Source: WormBase
  6. negative regulation of Ras protein signal transduction Source: WormBase
  7. negative regulation of transcription from RNA polymerase II promoter Source: WormBase
  8. negative regulation of vulval development Source: WormBase
  9. nematode male tail tip morphogenesis Source: WormBase
  10. positive regulation of transcription from RNA polymerase II promoter Source: WormBase
  11. regulation of cell differentiation Source: WormBase
  12. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Developmental protein, Hydrolase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 1 (EC:3.5.1.98)
Gene namesi
Name:hda-1
ORF Names:C53A5.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome V

Organism-specific databases

WormBaseiC53A5.3; CE08952; WBGene00001834; hda-1.

Subcellular locationi

Nucleus. Cytoplasm
Note: Except in the germ line where it is also cytoplasmic.

GO - Cellular componenti

  1. cytoplasm Source: WormBase
  2. germ cell nucleus Source: WormBase
  3. histone deacetylase complex Source: WormBase
  4. nucleus Source: WormBase
  5. NuRD complex Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi145 – 1451H → F: Loss of function.
Mutagenesisi186 – 1861G → E in gon-10; specific defects in gonadogenesis and vulval development. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 461461Histone deacetylase 1PRO_0000114719Add
BLAST

Post-translational modificationi

Sumoylated.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiO17695.

Expressioni

Tissue specificityi

Ubiquitously expressed throughout embryonic and postembryonic development.1 Publication

Developmental stagei

Expressed both maternally and zygotically.1 Publication

Interactioni

Subunit structurei

Interacts with pop-1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
pie-1Q941313EBI-318045,EBI-300501
pop-1Q106663EBI-318045,EBI-317870

Protein-protein interaction databases

BioGridi44961. 22 interactions.
DIPiDIP-26427N.
IntActiO17695. 11 interactions.
MINTiMINT-226391.
STRINGi6239.C53A5.3.2.

Structurei

3D structure databases

ProteinModelPortaliO17695.
SMRiO17695. Positions 12-377.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni13 – 325313Histone deacetylaseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0123.
GeneTreeiENSGT00530000062889.
HOGENOMiHOG000225180.
InParanoidiO17695.
KOiK06067.
OMAiQIQPDNE.
PhylomeDBiO17695.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

O17695-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNSNGPLMEH GKRRVAYYYD SNIGNYYYGQ GHVMKPHRIR MTHHLVLNYG
60 70 80 90 100
LYRNLEIFRP FPASFEDMTR FHSDEYMTFL KSANPDNLKS FNKQMLKFNV
110 120 130 140 150
GEDCPLFDGL YEFCQLSSGG SLAAATKLNK QKVDIAINWM GGLHHAKKSE
160 170 180 190 200
ASGFCYTNDI VLGILELLKY HKRVLYVDID VHHGDGVEEA FYTTDRVMTV
210 220 230 240 250
SFHKYGDFFP GTGDLKDIGA GKGKLYSVNV PLRDGITDVS YQSIFKPIMT
260 270 280 290 300
KVMERFDPCA VVLQCGADSL NGDRLGPFNL TLKGHGECAR FFRSYNVPLM
310 320 330 340 350
MVGGGGYTPR NVARCWTYET SIAVDKEVPN ELPYNDYFEY FGPNYRLHIE
360 370 380 390 400
SSNAANENSS DMLAKLQTDV IANLEQLTFV PSVQMRPIPE DALSALNDDS
410 420 430 440 450
LIADQANPDK RLPPQITDGM IQDDGDFYDG EREGDDRRNE SDAKRAAQFE
460
SEGGEKRQKT E
Length:461
Mass (Da):52,138
Last modified:January 1, 1998 - v1
Checksum:i9A104E88C5A1C07A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z81486 Genomic DNA. Translation: CAB03984.1.
PIRiT20163.
RefSeqiNP_506599.1. NM_074198.7.
UniGeneiCel.17341.

Genome annotation databases

EnsemblMetazoaiC53A5.3; C53A5.3; WBGene00001834.
GeneIDi179959.
KEGGicel:CELE_C53A5.3.
UCSCiC53A5.3.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z81486 Genomic DNA. Translation: CAB03984.1 .
PIRi T20163.
RefSeqi NP_506599.1. NM_074198.7.
UniGenei Cel.17341.

3D structure databases

ProteinModelPortali O17695.
SMRi O17695. Positions 12-377.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 44961. 22 interactions.
DIPi DIP-26427N.
IntActi O17695. 11 interactions.
MINTi MINT-226391.
STRINGi 6239.C53A5.3.2.

Proteomic databases

PaxDbi O17695.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai C53A5.3 ; C53A5.3 ; WBGene00001834 .
GeneIDi 179959.
KEGGi cel:CELE_C53A5.3.
UCSCi C53A5.3.1. c. elegans.

Organism-specific databases

CTDi 179959.
WormBasei C53A5.3 ; CE08952 ; WBGene00001834 ; hda-1.

Phylogenomic databases

eggNOGi COG0123.
GeneTreei ENSGT00530000062889.
HOGENOMi HOG000225180.
InParanoidi O17695.
KOi K06067.
OMAi QIQPDNE.
PhylomeDBi O17695.

Miscellaneous databases

NextBioi 907546.

Family and domain databases

Gene3Di 3.40.800.20. 1 hit.
InterProi IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PIRSFi PIRSF037913. His_deacetylse_1. 1 hit.
PRINTSi PR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "A POP-1 repressor complex restricts inappropriate cell type-specific gene transcription during Caenorhabditis elegans embryogenesis."
    Calvo D., Victor M., Gay F., Sui G., Luke M.P.-S., Dufourcq P., Wen G., Maduro M., Rothman J., Shi Y.
    EMBO J. 20:7197-7208(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH POP-1.
  3. "Functional requirement for histone deacetylase 1 in Caenorhabditis elegans gonadogenesis."
    Dufourcq P., Victor M., Gay F., Calvo D., Hodgkin J., Shi Y.
    Mol. Cell. Biol. 22:3024-3034(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, MUTAGENESIS OF GLY-186.
  4. "Chromatin regulation and sumoylation in the inhibition of Ras-induced vulval development in Caenorhabditis elegans."
    Poulin G., Dong Y., Fraser A.G., Hopper N.A., Ahringer J.
    EMBO J. 24:2613-2623(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION.

Entry informationi

Entry nameiHDA1_CAEEL
AccessioniPrimary (citable) accession number: O17695
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3