Reviewed, UniProtKB/Swiss-Prot O17695 (HDA1_CAEEL)

Names and origin

Protein names

Recommended name:
    Histone deacetylase 1
    EC=3.5.1.98

Gene names

Name:	hda-1
ORF Names:	C53A5.3

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	461 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in the endoderm determination possibly by repressing end-1 expression. Also involved in vulval development, possibly by repressing lag-2 expression. Ref.2 Ref.3
Catalytic activity	Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
Subunit structure	Interacts with pop-1. Ref.2
Subcellular location	Nucleus. Cytoplasm. Note: Except in the germ line where it is also cytoplasmic.
Tissue specificity	Ubiquitously expressed throughout embryonic and postembryonic development. Ref.3
Developmental stage	Expressed both maternally and zygotically. Ref.3
Post-translational modification	Sumoylated Probable.
Sequence similarities	Belongs to the histone deacetylase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Molecular function	Chromatin regulator Developmental protein Hydrolase Repressor
PTM	Ubl conjugation
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	embryonic development ending in birth or egg hatching Ref.3 Inferred from mutant phenotype. Source: WormBase gonad development Ref.3 Inferred from mutant phenotype. Source: WormBase hermaphrodite genitalia development Inferred from mutant phenotype. Source: WormBase histone deacetylation Inferred from electronic annotation. Source: InterPro negative regulation of vulval development Ref.4 Inferred from mutant phenotype. Source: WormBase positive regulation of growth rate Inferred from mutant phenotype. Source: WormBase regulation of transcription Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	histone deacetylase activity Inferred from electronic annotation. Source: InterPro protein binding Ref.2 Inferred from physical interaction. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
lin-35	O01682	1	EBI-318045,EBI-321470
lin-53	P90916	1	EBI-318045,EBI-324314

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 461	461	Histone deacetylase 1		PRO_0000114719
Regions
	Region	13 – 325	313	Histone deacetylase
Sites
	Active site	145	1	By similarity
Experimental info
	Mutagenesis	145	1	H → F: Loss of function.
	Mutagenesis	186	1	G → E in gon-10; specific defects in gonadogenesis and vulval development. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	O17695-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 9A104E88C5A1C07A	FASTA	461	52,138
	10 20 30 40 50 60 MNSNGPLMEH GKRRVAYYYD SNIGNYYYGQ GHVMKPHRIR MTHHLVLNYG LYRNLEIFRP 70 80 90 100 110 120 FPASFEDMTR FHSDEYMTFL KSANPDNLKS FNKQMLKFNV GEDCPLFDGL YEFCQLSSGG 130 140 150 160 170 180 SLAAATKLNK QKVDIAINWM GGLHHAKKSE ASGFCYTNDI VLGILELLKY HKRVLYVDID 190 200 210 220 230 240 VHHGDGVEEA FYTTDRVMTV SFHKYGDFFP GTGDLKDIGA GKGKLYSVNV PLRDGITDVS 250 260 270 280 290 300 YQSIFKPIMT KVMERFDPCA VVLQCGADSL NGDRLGPFNL TLKGHGECAR FFRSYNVPLM 310 320 330 340 350 360 MVGGGGYTPR NVARCWTYET SIAVDKEVPN ELPYNDYFEY FGPNYRLHIE SSNAANENSS 370 380 390 400 410 420 DMLAKLQTDV IANLEQLTFV PSVQMRPIPE DALSALNDDS LIADQANPDK RLPPQITDGM 430 440 450 460 IQDDGDFYDG EREGDDRRNE SDAKRAAQFE SEGGEKRQKT E

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
[2]	"A POP-1 repressor complex restricts inappropriate cell type-specific gene transcription during Caenorhabditis elegans embryogenesis." Calvo D., Victor M., Gay F., Sui G., Luke M.P.-S., Dufourcq P., Wen G., Maduro M., Rothman J., Shi Y. EMBO J. 20:7197-7208(2001) [PubMed: 11742996] [Abstract] Cited for: FUNCTION, INTERACTION WITH POP-1.
[3]	"Functional requirement for histone deacetylase 1 in Caenorhabditis elegans gonadogenesis." Dufourcq P., Victor M., Gay F., Calvo D., Hodgkin J., Shi Y. Mol. Cell. Biol. 22:3024-3034(2002) [PubMed: 11940660] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, MUTAGENESIS OF GLY-186.
[4]	"Chromatin regulation and sumoylation in the inhibition of Ras-induced vulval development in Caenorhabditis elegans." Poulin G., Dong Y., Fraser A.G., Hopper N.A., Ahringer J. EMBO J. 24:2613-2623(2005) [PubMed: 15990876] [Abstract] Cited for: SUMOYLATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z81486 Genomic DNA. Translation: CAB03984.1.
PIR	T20163.
RefSeq	NP_506599.1.
UniGene	Cel.17341
3D structure databases
HSSP	HSSP built from PDB template 1C3P based on UniProtKB O67135.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:26427N.
IntAct	O17695. 10 interactions.
STRING	O17695.
Genome annotation databases
Ensembl	C53A5.3.1; C53A5.3.1; C53A5.3; Caenorhabditis elegans. [Genome view] C53A5.3.2; C53A5.3.2; C53A5.3; Caenorhabditis elegans. [Genome view]
GeneID	179959.
KEGG	cel:C53A5.3.
UCSC	C53A5.3.1. c. elegans.
Organism-specific databases
CTD	179959.
WormBase	WBGene00001834. hda-1.
WormPep	C53A5.3. CE08952. [WorfDB]
Phylogenomic databases
OMA	GECARFF.
Gene expression databases
ArrayExpress	O17695.
Family and domain databases
InterPro	IPR000286. His_deacetylse. IPR003084. His_deacetylse_1. [Graphical view]
Gene3D	G3DSA:3.40.800.20. His_deacetylse. 1 hit.
PANTHER	PTHR10625. His_deacetylse. 1 hit. PTHR10625:SF28. His_deacetylse_1. 1 hit.
Pfam	PF00850. Hist_deacetyl. 1 hit. [Graphical view]
PIRSF	PIRSF037913. His_deacetylse_1. 1 hit.
PRINTS	PR01270. HDASUPER. PR01271. HISDACETLASE.
ProtoNet	Search...
Other Resources
NextBio	907546.

Entry information

Entry name

HDA1_CAEEL

Accession

Primary (citable) accession number: O17695

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	January 1, 1998
Last modified:	November 3, 2009
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project