Reviewed, UniProtKB/Swiss-Prot O17624 (C13B1_CAEEL)

Names and origin

Protein names

Recommended name:
    Putative cytochrome P450 cyp-13B1
    EC=1.14.-.-

Gene names

Name:	cyp-13B1
ORF Names:	F02C12.5

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	527 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Cofactor	Heme group By similarity.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro monooxygenase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform a Ref.1 (identifier: O17624-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform c Ref.1 (identifier: O17624-3)

The sequence of this isoform differs from the canonical sequence as follows:
     487-503: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 527	527	Putative cytochrome P450 cyp-13B1		PRO_0000051924
Sites
	Metal binding	456	1	Iron (heme axial ligand) By similarity UniProtKB Q27520
Natural variations
	Alternative sequence	487 – 503	17	Missing in isoform c. Ref.1		VSP_050222

Sequences

	Sequence		Length	Mass (Da)
	Isoform a [UniParc]. Last modified November 1, 1998. Version 2. Checksum: FFADF20F0531BDA5	FASTA	527	60,373
	10 20 30 40 50 60 MGAIIVLVVL FATIAGYFKW IHTYWRRRGI SGPEGLPFIG NYYDLADVNK PRGYLIHKWT 70 80 90 100 110 120 QKFGKVFGYY EGAVPVLVVS DMDMLQELFL KKFDNFYARK STNHIHGNLE CSKSEPRINL 130 140 150 160 170 180 FTSRGARWKR LRALASPGFS VKALKQVHDV MEDSAINMVD LMAKHEDGKP FNIHAYFQEF 190 200 210 220 230 240 TYDVISRLAM GQPNSELFNN SGVEIVKSIF MRTHRVLPWY FTVLFPQFEH LVKRMFYNHA 250 260 270 280 290 300 AVQGGDIEKL LLICKKTVES RIQEREENAK LGFENAENDF IDMFLNYYSE QVEDIEFGST 310 320 330 340 350 360 VEKKVTAEDV IGACFVFLLA GFDTTANSLA YASYLLAKHP EKMKLAQEEV DTVVGSENVS 370 380 390 400 410 420 YDDMTKLKYL DAVVRESLRL YPVAWFACSR ECVKPTTLGD IYIDKGVKIE ADVMSLHRSK 430 440 450 460 470 480 EIWGENADDF VPERWLEPSS RHTMSWIPFG AGPRQCVGMR LGLSEAKTAL AHLLRRYDLV 490 500 510 520 AGVETEVRLT LRFFFIFKSS QIQKELNILG CTTTSPEAVT LYLKPRI
	Isoform c. Checksum: B05B299244154584	FASTA	510	58,260
	10 20 30 40 50 60 MGAIIVLVVL FATIAGYFKW IHTYWRRRGI SGPEGLPFIG NYYDLADVNK PRGYLIHKWT 70 80 90 100 110 120 QKFGKVFGYY EGAVPVLVVS DMDMLQELFL KKFDNFYARK STNHIHGNLE CSKSEPRINL 130 140 150 160 170 180 FTSRGARWKR LRALASPGFS VKALKQVHDV MEDSAINMVD LMAKHEDGKP FNIHAYFQEF 190 200 210 220 230 240 TYDVISRLAM GQPNSELFNN SGVEIVKSIF MRTHRVLPWY FTVLFPQFEH LVKRMFYNHA 250 260 270 280 290 300 AVQGGDIEKL LLICKKTVES RIQEREENAK LGFENAENDF IDMFLNYYSE QVEDIEFGST 310 320 330 340 350 360 VEKKVTAEDV IGACFVFLLA GFDTTANSLA YASYLLAKHP EKMKLAQEEV DTVVGSENVS 370 380 390 400 410 420 YDDMTKLKYL DAVVRESLRL YPVAWFACSR ECVKPTTLGD IYIDKGVKIE ADVMSLHRSK 430 440 450 460 470 480 EIWGENADDF VPERWLEPSS RHTMSWIPFG AGPRQCVGMR LGLSEAKTAL AHLLRRYDLV 490 500 510 AGVETEKELN ILGCTTTSPE AVTLYLKPRI

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING. Strain: Bristol N2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z54269, Z92827 Genomic DNA. Translation: CAB54208.1. Z54269, Z92827 Genomic DNA. Translation: CAA91023.1. Z92827, Z54269 Genomic DNA. Translation: CAB07330.1. Z92827, Z54269 Genomic DNA. Translation: CAB54200.1.
PIR	T19575. T19576. T19577.
RefSeq	NP_510232.1.
UniGene	Cel.11068
3D structure databases
HSSP	HSSP built from PDB template 1JPZ based on UniProtKB P14779.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:25013N.
IntAct	O17624. 1 interaction.
Genome annotation databases
Ensembl	F02C12.5. Caenorhabditis elegans. [Contig view]
GeneID	181462.
KEGG	cel:F02C12.5.
Organism-specific databases
WormBase	WBGene00008519. cyp-13B1.
WormPep	F02C12.5a. CE09177. [WorfDB] F02C12.5c. CE23627. [WorfDB]
Gene expression databases
ArrayExpress	O17624.
Family and domain databases
InterPro	IPR001128. Cyt_P450. IPR017973. Cyt_P450_C. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. [Graphical view]
Gene3D	G3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHER	PTHR19383. Cyt_P450. 1 hit.
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR00385. P450.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	914044.

Entry information

Entry name

C13B1_CAEEL

Accession

Primary (citable) accession number: O17624
Secondary accession number(s): O17625, Q27491, Q9TVN5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	November 1, 1998
Last modified:	June 16, 2009
This is version 54 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project