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Protein

Putative cytochrome P450 cyp-13B1

Gene

cyp-13B1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases (Probable). They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics (Probable). May play a role in the regulation of lifespan (PubMed:19575768).Curated1 Publication

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi456Iron (heme axial ligand)By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-CEL-211958 Miscellaneous substrates
R-CEL-211979 Eicosanoids
R-CEL-211981 Xenobiotics
R-CEL-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
R-CEL-5423646 Aflatoxin activation and detoxification
R-CEL-9027307 Biosynthesis of maresin-like SPMs

Names & Taxonomyi

Protein namesi
Recommended name:
Putative cytochrome P450 cyp-13B1 (EC:1.14.-.-)
Gene namesi
Name:cyp-13B1Imported
ORF Names:F02C12.5Imported
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF02C12.5 ; CE23627 ; WBGene00008519 ; cyp-13B1

Pathology & Biotechi

Disruption phenotypei

RNAi-mediated knockdown results in a 25% increase in lifespan.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000519241 – 510Putative cytochrome P450 cyp-13B1Add BLAST510

Proteomic databases

PaxDbiO17624
PeptideAtlasiO17624
PRIDEiO17624

Expressioni

Gene expression databases

BgeeiWBGene00008519

Interactioni

Protein-protein interaction databases

BioGridi46365, 1 interactor
DIPiDIP-25013N
STRINGi6239.F02C12.5a

Structurei

3D structure databases

ProteinModelPortaliO17624
SMRiO17624
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Sequence analysis

Phylogenomic databases

eggNOGiKOG0158 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140779
HOGENOMiHOG000016177
InParanoidiO17624
KOiK17861
OrthoDBiEOG091G0JNC
PhylomeDBiO17624

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

O17624-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAIIVLVVL FATIAGYFKW IHTYWRRRGI SGPEGLPFIG NYYDLADVNK
60 70 80 90 100
PRGYLIHKWT QKFGKVFGYY EGAVPVLVVS DMDMLQELFL KKFDNFYARK
110 120 130 140 150
STNHIHGNLE CSKSEPRINL FTSRGARWKR LRALASPGFS VKALKQVHDV
160 170 180 190 200
MEDSAINMVD LMAKHEDGKP FNIHAYFQEF TYDVISRLAM GQPNSELFNN
210 220 230 240 250
SGVEIVKSIF MRTHRVLPWY FTVLFPQFEH LVKRMFYNHA AVQGGDIEKL
260 270 280 290 300
LLICKKTVES RIQEREENAK LGFENAENDF IDMFLNYYSE QVEDIEFGST
310 320 330 340 350
VEKKVTAEDV IGACFVFLLA GFDTTANSLA YASYLLAKHP EKMKLAQEEV
360 370 380 390 400
DTVVGSENVS YDDMTKLKYL DAVVRESLRL YPVAWFACSR ECVKPTTLGD
410 420 430 440 450
IYIDKGVKIE ADVMSLHRSK EIWGENADDF VPERWLEPSS RHTMSWIPFG
460 470 480 490 500
AGPRQCVGMR LGLSEAKTAL AHLLRRYDLV AGVETEKELN ILGCTTTSPE
510
AVTLYLKPRI
Length:510
Mass (Da):58,260
Last modified:February 15, 2017 - v3
Checksum:iB05B299244154584
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z54269, Z92827 Genomic DNA Translation: CAB54208.1
PIRiT19575
T19576
T19577
RefSeqiNP_510233.1, NM_077832.3
UniGeneiCel.11068

Genome annotation databases

EnsemblMetazoaiF02C12.5; F02C12.5; WBGene00008519
GeneIDi181462
KEGGicel:CELE_F02C12.5
UCSCiF02C12.5c c. elegans

Similar proteinsi

Entry informationi

Entry nameiC13B1_CAEEL
AccessioniPrimary (citable) accession number: O17624
Secondary accession number(s): O17625, Q27491, Q9TVN5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 15, 2017
Last modified: May 23, 2018
This is version 124 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

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