Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Putative cytochrome P450 cyp-13B1

Gene

cyp-13B1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.Curated

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi456Iron (heme axial ligand)By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-CEL-211958. Miscellaneous substrates.
R-CEL-211979. Eicosanoids.
R-CEL-211981. Xenobiotics.
R-CEL-2162123. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).
R-CEL-5423646. Aflatoxin activation and detoxification.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative cytochrome P450 cyp-13B1 (EC:1.14.-.-)
Gene namesi
ORF Names:F02C12.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF02C12.5a; CE09177; WBGene00008519; cyp-13B1.
F02C12.5c; CE23627; WBGene00008519; cyp-13B1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000519241 – 527Putative cytochrome P450 cyp-13B1Add BLAST527

Proteomic databases

PaxDbiO17624.
PeptideAtlasiO17624.

Expressioni

Gene expression databases

BgeeiWBGene00008519.

Interactioni

Protein-protein interaction databases

BioGridi46365. 1 interactor.
DIPiDIP-25013N.
MINTiMINT-1067324.
STRINGi6239.F02C12.5a.

Structurei

3D structure databases

ProteinModelPortaliO17624.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Sequence analysis

Phylogenomic databases

eggNOGiKOG0158. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118816.
HOGENOMiHOG000016177.
InParanoidiO17624.
KOiK17861.
OrthoDBiEOG091G0JNC.
PhylomeDBiO17624.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a1 Publication (identifier: O17624-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGAIIVLVVL FATIAGYFKW IHTYWRRRGI SGPEGLPFIG NYYDLADVNK
60 70 80 90 100
PRGYLIHKWT QKFGKVFGYY EGAVPVLVVS DMDMLQELFL KKFDNFYARK
110 120 130 140 150
STNHIHGNLE CSKSEPRINL FTSRGARWKR LRALASPGFS VKALKQVHDV
160 170 180 190 200
MEDSAINMVD LMAKHEDGKP FNIHAYFQEF TYDVISRLAM GQPNSELFNN
210 220 230 240 250
SGVEIVKSIF MRTHRVLPWY FTVLFPQFEH LVKRMFYNHA AVQGGDIEKL
260 270 280 290 300
LLICKKTVES RIQEREENAK LGFENAENDF IDMFLNYYSE QVEDIEFGST
310 320 330 340 350
VEKKVTAEDV IGACFVFLLA GFDTTANSLA YASYLLAKHP EKMKLAQEEV
360 370 380 390 400
DTVVGSENVS YDDMTKLKYL DAVVRESLRL YPVAWFACSR ECVKPTTLGD
410 420 430 440 450
IYIDKGVKIE ADVMSLHRSK EIWGENADDF VPERWLEPSS RHTMSWIPFG
460 470 480 490 500
AGPRQCVGMR LGLSEAKTAL AHLLRRYDLV AGVETEVRLT LRFFFIFKSS
510 520
QIQKELNILG CTTTSPEAVT LYLKPRI
Note: No experimental confirmation available.Curated
Length:527
Mass (Da):60,373
Last modified:November 1, 1998 - v2
Checksum:iFFADF20F0531BDA5
GO
Isoform c1 Publication (identifier: O17624-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     487-503: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:510
Mass (Da):58,260
Checksum:iB05B299244154584
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_050222487 – 503Missing in isoform c. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z54269, Z92827 Genomic DNA. Translation: CAB54208.1.
Z54269, Z92827 Genomic DNA. Translation: CAA91023.1.
PIRiT19575.
T19576.
T19577.
RefSeqiNP_510233.1. NM_077832.3. [O17624-3]
UniGeneiCel.11068.

Genome annotation databases

EnsemblMetazoaiF02C12.5a; F02C12.5a; WBGene00008519. [O17624-1]
GeneIDi181462.
KEGGicel:CELE_F02C12.5.
UCSCiF02C12.5c. c. elegans. [O17624-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z54269, Z92827 Genomic DNA. Translation: CAB54208.1.
Z54269, Z92827 Genomic DNA. Translation: CAA91023.1.
PIRiT19575.
T19576.
T19577.
RefSeqiNP_510233.1. NM_077832.3. [O17624-3]
UniGeneiCel.11068.

3D structure databases

ProteinModelPortaliO17624.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi46365. 1 interactor.
DIPiDIP-25013N.
MINTiMINT-1067324.
STRINGi6239.F02C12.5a.

Proteomic databases

PaxDbiO17624.
PeptideAtlasiO17624.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF02C12.5a; F02C12.5a; WBGene00008519. [O17624-1]
GeneIDi181462.
KEGGicel:CELE_F02C12.5.
UCSCiF02C12.5c. c. elegans. [O17624-1]

Organism-specific databases

CTDi181462.
WormBaseiF02C12.5a; CE09177; WBGene00008519; cyp-13B1.
F02C12.5c; CE23627; WBGene00008519; cyp-13B1.

Phylogenomic databases

eggNOGiKOG0158. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118816.
HOGENOMiHOG000016177.
InParanoidiO17624.
KOiK17861.
OrthoDBiEOG091G0JNC.
PhylomeDBiO17624.

Enzyme and pathway databases

ReactomeiR-CEL-211958. Miscellaneous substrates.
R-CEL-211979. Eicosanoids.
R-CEL-211981. Xenobiotics.
R-CEL-2162123. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).
R-CEL-5423646. Aflatoxin activation and detoxification.

Miscellaneous databases

PROiO17624.

Gene expression databases

BgeeiWBGene00008519.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC13B1_CAEEL
AccessioniPrimary (citable) accession number: O17624
Secondary accession number(s): O17625, Q27491, Q9TVN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.