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Protein
Submitted name:

Uncharacterized protein

Gene

eat-16

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • GTPase activator activity Source: WormBase
  • signal transducer activity Source: InterPro

GO - Biological processi

  • dopamine receptor signaling pathway Source: WormBase
  • intracellular signal transduction Source: InterPro
  • modulation of synaptic transmission Source: WormBase
  • negative regulation of locomotion Source: WormBase
  • nematode larval development Source: WormBase
  • phospholipase C-inhibiting G-protein coupled receptor signaling pathway Source: WormBase
  • regulation of G-protein coupled receptor protein signaling pathway Source: WormBase
  • regulation of GTPase activity Source: WormBase
  • regulation of locomotion Source: WormBase
  • regulation of oviposition Source: WormBase
  • regulation of pharyngeal pumping Source: WormBase
  • reproduction Source: WormBase
  • response to food Source: WormBase
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:eat-16Imported
ORF Names:C16C2.2Imported, CELE_C16C2.2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiC16C2.2a; CE17404; WBGene00001145; eat-16.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: WormBase
  • heterotrimeric G-protein complex Source: InterPro
  • membrane Source: WormBase
  • neuron projection Source: WormBase
  • plasma membrane Source: WormBase
Complete GO annotation...

PTM / Processingi

Proteomic databases

EPDiO17589.
PaxDbiO17589.
PRIDEiO17589.

Expressioni

Gene expression databases

ExpressionAtlasiO17589. baseline.

Interactioni

Protein-protein interaction databases

STRINGi6239.C16C2.2a.2.

Structurei

3D structure databases

ProteinModelPortaliO17589.
SMRiO17589. Positions 2-410.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 9076DEPInterPro annotationAdd
BLAST
Domaini287 – 407121RGSInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RGS domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG3589. Eukaryota.
ENOG410YMJD. LUCA.
GeneTreeiENSGT00760000119142.
HOGENOMiHOG000220864.
InParanoidiO17589.
KOiK16449.
OMAiWISDEAS.
PhylomeDBiO17589.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.196.10. 1 hit.
4.10.260.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR015898. G-protein_gamma-like_dom.
IPR016137. RGS.
IPR024066. RGS_subdom1.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00610. DEP. 1 hit.
PF00631. G-gamma. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00049. DEP. 1 hit.
SM00224. GGL. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF48097. SSF48097. 1 hit.
SSF48670. SSF48670. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O17589-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMPPLTKIEV LAKRVMEGAQ LKTHKYFRIA VPHAITGQQL IALVLERGAP
60 70 80 90 100
DDEAEASHLA SLLLHHGYMF PVIEHGQPFK DDGTLYRLQR PYFWPSQAEL
110 120 130 140 150
VPDVEYAIYL NKRLLRNEQK HGLEEDEVES FNRLADVLAH MWAFIVQQSE
160 170 180 190 200
LQLKQQKEKK KVDKVVFDSE ERAFWKIRKP SRGGPNFLED PYMKIEKKIR
210 220 230 240 250
RQNAQGYRCL MDRLRFAIKT KPWLKALKAS DTMVTWVDQR AEFDPFLHPP
260 270 280 290 300
QPSNPWISDE ASFWNQPTDT SSAEIPTEKR VKRWGLSVQE LVKDPIGRQV
310 320 330 340 350
LETFLESEFS SENIRFWIAI QDLKYAPNEQ IYQKAERIRE EFLAQGAPAQ
360 370 380 390 400
VNVDNRTLDQ TLECISKAKD ASQMRFAFYH SEEHVFTLMA KDSYPRFVRS
410 420 430 440 450
QIYKAVLTAA QQHGTKRLGW RNFVFNMGTT KKPATSKPAK PQDSIGTGQV
460 470
LPKQLSSDSL PVRQAHGVKP DPE
Length:473
Mass (Da):54,686
Last modified:August 1, 1998 - v2
Checksum:i27B0CD420A8B34D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CAB02742.1.
PIRiT19337.
RefSeqiNP_740904.1. NM_170911.4.
UniGeneiCel.20772.

Genome annotation databases

EnsemblMetazoaiC16C2.2a.1; C16C2.2a.1; WBGene00001145.
C16C2.2a.2; C16C2.2a.2; WBGene00001145.
GeneIDi172823.
KEGGicel:CELE_C16C2.2.
UCSCiC16C2.2a.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CAB02742.1.
PIRiT19337.
RefSeqiNP_740904.1. NM_170911.4.
UniGeneiCel.20772.

3D structure databases

ProteinModelPortaliO17589.
SMRiO17589. Positions 2-410.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C16C2.2a.2.

Proteomic databases

EPDiO17589.
PaxDbiO17589.
PRIDEiO17589.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC16C2.2a.1; C16C2.2a.1; WBGene00001145.
C16C2.2a.2; C16C2.2a.2; WBGene00001145.
GeneIDi172823.
KEGGicel:CELE_C16C2.2.
UCSCiC16C2.2a.1. c. elegans.

Organism-specific databases

CTDi172823.
WormBaseiC16C2.2a; CE17404; WBGene00001145; eat-16.

Phylogenomic databases

eggNOGiKOG3589. Eukaryota.
ENOG410YMJD. LUCA.
GeneTreeiENSGT00760000119142.
HOGENOMiHOG000220864.
InParanoidiO17589.
KOiK16449.
OMAiWISDEAS.
PhylomeDBiO17589.

Gene expression databases

ExpressionAtlasiO17589. baseline.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.196.10. 1 hit.
4.10.260.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR015898. G-protein_gamma-like_dom.
IPR016137. RGS.
IPR024066. RGS_subdom1.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00610. DEP. 1 hit.
PF00631. G-gamma. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00049. DEP. 1 hit.
SM00224. GGL. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF48097. SSF48097. 1 hit.
SSF48670. SSF48670. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiO17589_CAEEL
AccessioniPrimary (citable) accession number: O17589
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: August 1, 1998
Last modified: July 6, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.