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O17586

- PSA6_CAEEL

UniProt

O17586 - PSA6_CAEEL

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Protein

Proteasome subunit alpha type-6

Gene

pas-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity By similarity.By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

  1. threonine-type endopeptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiREACT_101459. Regulation of activated PAK-2p34 by proteasome mediated degradation.
REACT_183279. ER-Phagosome pathway.
REACT_183284. Cross-presentation of soluble exogenous antigens (endosomes).
REACT_183296. Antigen processing: Ubiquitination & Proteasome degradation.
REACT_184635. Orc1 removal from chromatin.
REACT_205379. SCF-beta-TrCP mediated degradation of Emi1.
REACT_215136. Asymmetric localization of PCP proteins.

Protein family/group databases

MEROPSiT01.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alpha type-6 (EC:3.4.25.1)
Alternative name(s):
Proteasome subunit alpha 1
Gene namesi
Name:pas-1
ORF Names:C15H11.7
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome V

Organism-specific databases

WormBaseiC15H11.7; CE08184; WBGene00003922; pas-1.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
  3. proteasome core complex, alpha-subunit complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 246246Proteasome subunit alpha type-6PRO_0000124133Add
BLAST

Proteomic databases

PaxDbiO17586.

2D gel databases

World-2DPAGE0020:O17586.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
pas-7Q095836EBI-315388,EBI-315406

Protein-protein interaction databases

BioGridi44945. 7 interactions.
IntActiO17586. 7 interactions.
MINTiMINT-211228.
STRINGi6239.C15H11.7.1.

Structurei

3D structure databases

ProteinModelPortaliO17586.
SMRiO17586. Positions 2-243.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0638.
GeneTreeiENSGT00550000074807.
HOGENOMiHOG000091084.
InParanoidiO17586.
KOiK02730.
OMAiMSRTSYD.
PhylomeDBiO17586.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTiSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O17586-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRGSSAGFD RHITIFSPEG RVYQVEYAFK AINSTNLTAV AVKGADAAVI
60 70 80 90 100
AVQKRVPDSL IVADTVTSVY QISQSVGCCA IGMIPDAKFQ IKRAQGEAAS
110 120 130 140 150
WKYKNGYDMP CELLAKKMAD LNQYYTQNAE MRSLGCALLF ISYDDEKGPE
160 170 180 190 200
VYRVDPAGYY RGMKGVSVGV KQLPATSFLE KKIKKKSELT STEAIELAIE
210 220 230 240
ALQTSLGIDV RSKDLEVVVV TKDNSKFTKL TSDQVEHHLN QIANRD
Length:246
Mass (Da):27,049
Last modified:January 1, 1998 - v1
Checksum:iACB71BDEC523547C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z81035 Genomic DNA. Translation: CAB02738.1.
PIRiT19320.
RefSeqiNP_506571.1. NM_074170.3.
UniGeneiCel.2930.

Genome annotation databases

EnsemblMetazoaiC15H11.7; C15H11.7; WBGene00003922.
GeneIDi179941.
KEGGicel:CELE_C15H11.7.
UCSCiC15H11.7.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z81035 Genomic DNA. Translation: CAB02738.1 .
PIRi T19320.
RefSeqi NP_506571.1. NM_074170.3.
UniGenei Cel.2930.

3D structure databases

ProteinModelPortali O17586.
SMRi O17586. Positions 2-243.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 44945. 7 interactions.
IntActi O17586. 7 interactions.
MINTi MINT-211228.
STRINGi 6239.C15H11.7.1.

Protein family/group databases

MEROPSi T01.971.

2D gel databases

World-2DPAGE 0020:O17586.

Proteomic databases

PaxDbi O17586.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai C15H11.7 ; C15H11.7 ; WBGene00003922 .
GeneIDi 179941.
KEGGi cel:CELE_C15H11.7.
UCSCi C15H11.7.1. c. elegans.

Organism-specific databases

CTDi 179941.
WormBasei C15H11.7 ; CE08184 ; WBGene00003922 ; pas-1.

Phylogenomic databases

eggNOGi COG0638.
GeneTreei ENSGT00550000074807.
HOGENOMi HOG000091084.
InParanoidi O17586.
KOi K02730.
OMAi MSRTSYD.
PhylomeDBi O17586.

Enzyme and pathway databases

Reactomei REACT_101459. Regulation of activated PAK-2p34 by proteasome mediated degradation.
REACT_183279. ER-Phagosome pathway.
REACT_183284. Cross-presentation of soluble exogenous antigens (endosomes).
REACT_183296. Antigen processing: Ubiquitination & Proteasome degradation.
REACT_184635. Orc1 removal from chromatin.
REACT_205379. SCF-beta-TrCP mediated degradation of Emi1.
REACT_215136. Asymmetric localization of PCP proteins.

Miscellaneous databases

NextBioi 907482.
PROi O17586.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
InterProi IPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view ]
Pfami PF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view ]
SMARTi SM00948. Proteasome_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
PROSITEi PS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiPSA6_CAEEL
AccessioniPrimary (citable) accession number: O17586
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3