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O17586

- PSA6_CAEEL

UniProt

O17586 - PSA6_CAEEL

Protein

Proteasome subunit alpha type-6

Gene

pas-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity By similarity.By similarity

    Catalytic activityi

    Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. threonine-type endopeptidase activity Source: UniProtKB-KW

    GO - Biological processi

    1. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Threonine protease

    Enzyme and pathway databases

    ReactomeiREACT_101459. Regulation of activated PAK-2p34 by proteasome mediated degradation.
    REACT_183279. ER-Phagosome pathway.
    REACT_183284. Cross-presentation of soluble exogenous antigens (endosomes).
    REACT_183296. Antigen processing: Ubiquitination & Proteasome degradation.
    REACT_184635. Orc1 removal from chromatin.
    REACT_205379. SCF-beta-TrCP mediated degradation of Emi1.
    REACT_215136. Asymmetric localization of PCP proteins.

    Protein family/group databases

    MEROPSiT01.971.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proteasome subunit alpha type-6 (EC:3.4.25.1)
    Alternative name(s):
    Proteasome subunit alpha 1
    Gene namesi
    Name:pas-1
    ORF Names:C15H11.7
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome V

    Organism-specific databases

    WormBaseiC15H11.7; CE08184; WBGene00003922; pas-1.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell
    3. proteasome core complex, alpha-subunit complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Proteasome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 246246Proteasome subunit alpha type-6PRO_0000124133Add
    BLAST

    Proteomic databases

    PaxDbiO17586.

    2D gel databases

    World-2DPAGE0020:O17586.

    Interactioni

    Subunit structurei

    The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    pas-7Q095836EBI-315388,EBI-315406

    Protein-protein interaction databases

    BioGridi44945. 7 interactions.
    IntActiO17586. 7 interactions.
    MINTiMINT-211228.
    STRINGi6239.C15H11.7.1.

    Structurei

    3D structure databases

    ProteinModelPortaliO17586.
    SMRiO17586. Positions 2-243.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase T1A family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0638.
    GeneTreeiENSGT00550000074807.
    HOGENOMiHOG000091084.
    InParanoidiO17586.
    KOiK02730.
    OMAiMSRTSYD.
    PhylomeDBiO17586.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    InterProiIPR029055. Ntn_hydrolases_N.
    IPR000426. Proteasome_asu_N.
    IPR023332. Proteasome_suA-type.
    IPR001353. Proteasome_sua/b.
    [Graphical view]
    PfamiPF00227. Proteasome. 1 hit.
    PF10584. Proteasome_A_N. 1 hit.
    [Graphical view]
    SMARTiSM00948. Proteasome_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    PROSITEiPS00388. PROTEASOME_ALPHA_1. 1 hit.
    PS51475. PROTEASOME_ALPHA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O17586-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRGSSAGFD RHITIFSPEG RVYQVEYAFK AINSTNLTAV AVKGADAAVI    50
    AVQKRVPDSL IVADTVTSVY QISQSVGCCA IGMIPDAKFQ IKRAQGEAAS 100
    WKYKNGYDMP CELLAKKMAD LNQYYTQNAE MRSLGCALLF ISYDDEKGPE 150
    VYRVDPAGYY RGMKGVSVGV KQLPATSFLE KKIKKKSELT STEAIELAIE 200
    ALQTSLGIDV RSKDLEVVVV TKDNSKFTKL TSDQVEHHLN QIANRD 246
    Length:246
    Mass (Da):27,049
    Last modified:January 1, 1998 - v1
    Checksum:iACB71BDEC523547C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z81035 Genomic DNA. Translation: CAB02738.1.
    PIRiT19320.
    RefSeqiNP_506571.1. NM_074170.3.
    UniGeneiCel.2930.

    Genome annotation databases

    EnsemblMetazoaiC15H11.7; C15H11.7; WBGene00003922.
    GeneIDi179941.
    KEGGicel:CELE_C15H11.7.
    UCSCiC15H11.7.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z81035 Genomic DNA. Translation: CAB02738.1 .
    PIRi T19320.
    RefSeqi NP_506571.1. NM_074170.3.
    UniGenei Cel.2930.

    3D structure databases

    ProteinModelPortali O17586.
    SMRi O17586. Positions 2-243.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 44945. 7 interactions.
    IntActi O17586. 7 interactions.
    MINTi MINT-211228.
    STRINGi 6239.C15H11.7.1.

    Protein family/group databases

    MEROPSi T01.971.

    2D gel databases

    World-2DPAGE 0020:O17586.

    Proteomic databases

    PaxDbi O17586.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai C15H11.7 ; C15H11.7 ; WBGene00003922 .
    GeneIDi 179941.
    KEGGi cel:CELE_C15H11.7.
    UCSCi C15H11.7.1. c. elegans.

    Organism-specific databases

    CTDi 179941.
    WormBasei C15H11.7 ; CE08184 ; WBGene00003922 ; pas-1.

    Phylogenomic databases

    eggNOGi COG0638.
    GeneTreei ENSGT00550000074807.
    HOGENOMi HOG000091084.
    InParanoidi O17586.
    KOi K02730.
    OMAi MSRTSYD.
    PhylomeDBi O17586.

    Enzyme and pathway databases

    Reactomei REACT_101459. Regulation of activated PAK-2p34 by proteasome mediated degradation.
    REACT_183279. ER-Phagosome pathway.
    REACT_183284. Cross-presentation of soluble exogenous antigens (endosomes).
    REACT_183296. Antigen processing: Ubiquitination & Proteasome degradation.
    REACT_184635. Orc1 removal from chromatin.
    REACT_205379. SCF-beta-TrCP mediated degradation of Emi1.
    REACT_215136. Asymmetric localization of PCP proteins.

    Miscellaneous databases

    NextBioi 907482.
    PROi O17586.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    InterProi IPR029055. Ntn_hydrolases_N.
    IPR000426. Proteasome_asu_N.
    IPR023332. Proteasome_suA-type.
    IPR001353. Proteasome_sua/b.
    [Graphical view ]
    Pfami PF00227. Proteasome. 1 hit.
    PF10584. Proteasome_A_N. 1 hit.
    [Graphical view ]
    SMARTi SM00948. Proteasome_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    PROSITEi PS00388. PROTEASOME_ALPHA_1. 1 hit.
    PS51475. PROTEASOME_ALPHA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiPSA6_CAEEL
    AccessioniPrimary (citable) accession number: O17586
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 8, 2000
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3