O17586 (PSA6_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Proteasome subunit alpha type-6
EC=3.4.25.1

Alternative name(s):
Proteasome subunit alpha 1

Gene names

Name:	pas-1
ORF Names:	C15H11.7

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	246 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity By similarity.
Catalytic activity	Cleavage of peptide bonds with very broad specificity.
Subunit structure	The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the peptidase T1A family.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus Proteasome
Molecular function	Hydrolase Protease Threonine protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	determination of adult lifespan Inferred from mutant phenotype. Source: WormBase embryo development ending in birth or egg hatching Inferred from mutant phenotype. Source: WormBase growth Inferred from mutant phenotype. Source: WormBase locomotion Inferred from mutant phenotype. Source: WormBase molting cycle, collagen and cuticulin-based cuticle Inferred from mutant phenotype. Source: WormBase negative regulation of multicellular organism growth Inferred from mutant phenotype. Source: WormBase nematode larval development Inferred from mutant phenotype. Source: WormBase reproduction Inferred from mutant phenotype. Source: WormBase ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell proteasome core complex, alpha-subunit complex Inferred from electronic annotation. Source: InterPro
Molecular function	protein binding Inferred from physical interaction. Source: IntAct threonine-type endopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
pas-7	Q09583	6	EBI-315388,EBI-315406

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 246	246	Proteasome subunit alpha type-6		PRO_0000124133

Sequences

	Sequence		Length	Mass (Da)
	O17586 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: ACB71BDEC523547C	FASTA	246	27,049
	10 20 30 40 50 60 MSRGSSAGFD RHITIFSPEG RVYQVEYAFK AINSTNLTAV AVKGADAAVI AVQKRVPDSL 70 80 90 100 110 120 IVADTVTSVY QISQSVGCCA IGMIPDAKFQ IKRAQGEAAS WKYKNGYDMP CELLAKKMAD 130 140 150 160 170 180 LNQYYTQNAE MRSLGCALLF ISYDDEKGPE VYRVDPAGYY RGMKGVSVGV KQLPATSFLE 190 200 210 220 230 240 KKIKKKSELT STEAIELAIE ALQTSLGIDV RSKDLEVVVV TKDNSKFTKL TSDQVEHHLN QIANRD

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z81035 Genomic DNA. Translation: CAB02738.1.
PIR	T19320.
RefSeq	NP_506571.1. NM_074170.2.
UniGene	Cel.2930.
3D structure databases
ProteinModelPortal	O17586.
SMR	O17586. Positions 2-245.
ModBase	Search...
Protein-protein interaction databases
IntAct	O17586. 7 interactions.
MINT	MINT-211228.
STRING	O17586.
Protein family/group databases
MEROPS	T01.971.
2D gel databases
World-2DPAGE	0020:O17586.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	C15H11.7.1; C15H11.7.1; C15H11.7.
GeneID	179941.
KEGG	cel:C15H11.7.
UCSC	C15H11.7.1. c. elegans.
Organism-specific databases
CTD	179941.
WormBase	C15H11.7; CE08184; WBGene00003922; pas-1.
Phylogenomic databases
eggNOG	meNOG04168.
GeneTree	EMGT00050000009409.
HOGENOM	HBG499923.
InParanoid	O17586.
OMA	GKDCAVV.
PhylomeDB	O17586.
Gene expression databases
ArrayExpress	O17586.
Family and domain databases
InterPro	IPR000426. Proteasome_asu_N. IPR023332. Proteasome_suA-type. IPR001353. Proteasome_sua/b. [Graphical view]
KO	K02730.
Pfam	PF00227. Proteasome. 1 hit. PF10584. Proteasome_A_N. 1 hit. [Graphical view]
SMART	SM00948. Proteasome_A_N. 1 hit. [Graphical view]
PROSITE	PS00388. PROTEASOME_A_1. 1 hit. PS51475. PROTEASOME_A_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	907482.

Entry information

Entry name

PSA6_CAEEL

Accession

Primary (citable) accession number: O17586

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 8, 2000
Last sequence update:	January 1, 1998
Last modified:	January 25, 2012
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project