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Protein

Proteasome subunit alpha type-6

Gene

pas-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiR-CEL-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-CEL-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-CEL-382556. ABC-family proteins mediated transport.
R-CEL-4641258. Degradation of DVL.
R-CEL-5689603. UCH proteinases.
R-CEL-5689880. Ub-specific processing proteases.
R-CEL-68949. Orc1 removal from chromatin.
R-CEL-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-CEL-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-CEL-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-CEL-8941858. Regulation of RUNX3 expression and activity.
R-CEL-8948751. Regulation of PTEN stability and activity.
R-CEL-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Protein family/group databases

MEROPSiT01.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alpha type-6 (EC:3.4.25.1)
Alternative name(s):
Proteasome subunit alpha 1
Gene namesi
Name:pas-1
ORF Names:C15H11.7
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiC15H11.7; CE08184; WBGene00003922; pas-1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001241331 – 246Proteasome subunit alpha type-6Add BLAST246

Proteomic databases

EPDiO17586.
PaxDbiO17586.
PeptideAtlasiO17586.
PRIDEiO17586.

2D gel databases

World-2DPAGEi0020:O17586.

PTM databases

iPTMnetiO17586.

Expressioni

Gene expression databases

BgeeiWBGene00003922.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
pas-7Q095836EBI-315388,EBI-315406

Protein-protein interaction databases

BioGridi44945. 7 interactors.
IntActiO17586. 7 interactors.
MINTiMINT-211228.
STRINGi6239.C15H11.7.2.

Structurei

3D structure databases

ProteinModelPortaliO17586.
SMRiO17586.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0182. Eukaryota.
ENOG410XR7X. LUCA.
GeneTreeiENSGT00550000074807.
HOGENOMiHOG000091084.
InParanoidiO17586.
KOiK02730.
OMAiYGYEITP.
OrthoDBiEOG091G0GSR.
PhylomeDBiO17586.

Family and domain databases

CDDicd03754. proteasome_alpha_type_6. 1 hit.
Gene3Di3.60.20.10. 1 hit.
InterProiView protein in InterPro
IPR029055. Ntn_hydrolases_N.
IPR023332. Proteasome_alpha-type.
IPR000426. Proteasome_asu_N.
IPR001353. Proteasome_sua/b.
IPR034642. Proteasome_subunit_alpha6.
PANTHERiPTHR11599:SF11. PTHR11599:SF11. 1 hit.
PfamiView protein in Pfam
PF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
SMARTiView protein in SMART
SM00948. Proteasome_A_N. 1 hit.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiView protein in PROSITE
PS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O17586-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRGSSAGFD RHITIFSPEG RVYQVEYAFK AINSTNLTAV AVKGADAAVI
60 70 80 90 100
AVQKRVPDSL IVADTVTSVY QISQSVGCCA IGMIPDAKFQ IKRAQGEAAS
110 120 130 140 150
WKYKNGYDMP CELLAKKMAD LNQYYTQNAE MRSLGCALLF ISYDDEKGPE
160 170 180 190 200
VYRVDPAGYY RGMKGVSVGV KQLPATSFLE KKIKKKSELT STEAIELAIE
210 220 230 240
ALQTSLGIDV RSKDLEVVVV TKDNSKFTKL TSDQVEHHLN QIANRD
Length:246
Mass (Da):27,049
Last modified:January 1, 1998 - v1
Checksum:iACB71BDEC523547C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81035 Genomic DNA. Translation: CAB02738.1.
PIRiT19320.
RefSeqiNP_506571.1. NM_074170.3.
UniGeneiCel.2930.

Genome annotation databases

EnsemblMetazoaiC15H11.7; C15H11.7; WBGene00003922.
GeneIDi179941.
KEGGicel:CELE_C15H11.7.
UCSCiC15H11.7.1. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiPSA6_CAEEL
AccessioniPrimary (citable) accession number: O17586
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: January 1, 1998
Last modified: November 22, 2017
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families