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O17473

- CATL_BRUPA

UniProt

O17473 - CATL_BRUPA

Protein

Cathepsin L-like

Gene
N/A
Organism
Brugia pahangi (Filarial nematode worm)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei206 – 2061By similarity
    Active sitei342 – 3421By similarity
    Active sitei363 – 3631By similarity

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cathepsin L-like (EC:3.4.22.15)
    OrganismiBrugia pahangi (Filarial nematode worm)
    Taxonomic identifieri6280 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaSpiruridaFilarioideaOnchocercidaeBrugia

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Propeptidei17 – 181165Activation peptideSequence AnalysisPRO_0000026293Add
    BLAST
    Chaini182 – 395214Cathepsin L-likePRO_0000026294Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi203 ↔ 2461 Publication
    Disulfide bondi237 ↔ 2781 Publication
    Disulfide bondi337 ↔ 3851 Publication

    Keywords - PTMi

    Disulfide bond, Zymogen

    Structurei

    Secondary structure

    1
    395
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni188 – 1925
    Beta strandi202 – 2043
    Helixi206 – 22318
    Helixi231 – 2377
    Helixi251 – 2588
    Beta strandi259 – 2613
    Turni266 – 2683
    Beta strandi279 – 2835
    Helixi300 – 31011
    Beta strandi313 – 3164
    Helixi322 – 3265
    Beta strandi343 – 3497
    Beta strandi358 – 3625
    Beta strandi367 – 3693
    Beta strandi374 – 3785
    Helixi384 – 3863

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1BMUmodel-A182-395[»]
    ProteinModelPortaliO17473.
    SMRiO17473. Positions 182-395.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Family and domain databases

    InterProiIPR025661. Pept_asp_AS.
    IPR000169. Pept_cys_AS.
    IPR013128. Peptidase_C1A.
    IPR000668. Peptidase_C1A_C.
    IPR013201. Prot_inhib_I29.
    [Graphical view]
    PANTHERiPTHR12411. PTHR12411. 1 hit.
    PfamiPF08246. Inhibitor_I29. 1 hit.
    PF00112. Peptidase_C1. 1 hit.
    [Graphical view]
    PRINTSiPR00705. PAPAIN.
    SMARTiSM00848. Inhibitor_I29. 1 hit.
    SM00645. Pept_C1. 1 hit.
    [Graphical view]
    PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
    PS00139. THIOL_PROTEASE_CYS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O17473-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWTIAQLAVF AILALADFAV AGEIEQLKEV LGKFNKDYKQ GNMTRLASDF    50
    RSALKEYGDG QQGESTVVQE FLKKTEDNGE QRAMEKLETE WKDYVTALGK 100
    HYDQKENNFR MAIFESNELM TERINKKYEQ GLVSYTTALN DLADLTDEEF 150
    MVRNGLRLPN QTDLRGKRQT SEFYRYDKSE RLPDQVDWRT KGAVTPVRNQ 200
    GECGSCYAFA TAAALEAYHK QMTGRLLDLS PQNIVDCTRN LGNNGCSGGY 250
    MPTAFQYASR YGIAMESRYP YVGTEQRCRW QQSIAVVTDN GFNEIQPGDE 300
    LALKHAVAKR GPVVVGISGS KRSFRFYKDG VYSEGNCGRP DHAVLAVGYG 350
    THPSYGDYWI VKNSWGTDWG KDGYVYMARN RGNMCHIASA ASFPI 395
    Length:395
    Mass (Da):44,549
    Last modified:January 1, 1998 - v1
    Checksum:i6EC65C20333BE2D1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF031819 mRNA. Translation: AAB86867.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF031819 mRNA. Translation: AAB86867.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1BMU model - A 182-395 [» ]
    ProteinModelPortali O17473.
    SMRi O17473. Positions 182-395.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR025661. Pept_asp_AS.
    IPR000169. Pept_cys_AS.
    IPR013128. Peptidase_C1A.
    IPR000668. Peptidase_C1A_C.
    IPR013201. Prot_inhib_I29.
    [Graphical view ]
    PANTHERi PTHR12411. PTHR12411. 1 hit.
    Pfami PF08246. Inhibitor_I29. 1 hit.
    PF00112. Peptidase_C1. 1 hit.
    [Graphical view ]
    PRINTSi PR00705. PAPAIN.
    SMARTi SM00848. Inhibitor_I29. 1 hit.
    SM00645. Pept_C1. 1 hit.
    [Graphical view ]
    PROSITEi PS00640. THIOL_PROTEASE_ASN. 1 hit.
    PS00139. THIOL_PROTEASE_CYS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cathepsin L-like cysteine protease from Brugia pahangi third stage larvae."
      Selzer P.M., Huong X., Britton C., McKerrow J.H.
      Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Molecular model of Brugia pahangi third-stage larvae cysteine protease."
      Selzer P.M., Chen X., Cohen F.E., McKerrow J.H.
      Submitted (JUL-1998) to the PDB data bank
      Cited for: 3D-STRUCTURE MODELING OF 182-395, DISULFIDE BONDS.

    Entry informationi

    Entry nameiCATL_BRUPA
    AccessioniPrimary (citable) accession number: O17473
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    3D-structure

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3