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Protein

Cathepsin L-like

Gene
N/A
Organism
Brugia pahangi (Filarial nematode worm)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei206 – 2061By similarity
Active sitei342 – 3421By similarity
Active sitei363 – 3631By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Names & Taxonomyi

Protein namesi
Recommended name:
Cathepsin L-like (EC:3.4.22.15)
OrganismiBrugia pahangi (Filarial nematode worm)
Taxonomic identifieri6280 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaSpiruridaFilarioideaOnchocercidaeBrugia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence AnalysisAdd
BLAST
Propeptidei17 – 181165Activation peptideSequence AnalysisPRO_0000026293Add
BLAST
Chaini182 – 395214Cathepsin L-likePRO_0000026294Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi203 ↔ 2461 Publication
Disulfide bondi237 ↔ 2781 Publication
Disulfide bondi337 ↔ 3851 Publication

Keywords - PTMi

Disulfide bond, Zymogen

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BMUmodel-A182-395[»]
ProteinModelPortaliO17473.
SMRiO17473. Positions 182-395.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O17473-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWTIAQLAVF AILALADFAV AGEIEQLKEV LGKFNKDYKQ GNMTRLASDF
60 70 80 90 100
RSALKEYGDG QQGESTVVQE FLKKTEDNGE QRAMEKLETE WKDYVTALGK
110 120 130 140 150
HYDQKENNFR MAIFESNELM TERINKKYEQ GLVSYTTALN DLADLTDEEF
160 170 180 190 200
MVRNGLRLPN QTDLRGKRQT SEFYRYDKSE RLPDQVDWRT KGAVTPVRNQ
210 220 230 240 250
GECGSCYAFA TAAALEAYHK QMTGRLLDLS PQNIVDCTRN LGNNGCSGGY
260 270 280 290 300
MPTAFQYASR YGIAMESRYP YVGTEQRCRW QQSIAVVTDN GFNEIQPGDE
310 320 330 340 350
LALKHAVAKR GPVVVGISGS KRSFRFYKDG VYSEGNCGRP DHAVLAVGYG
360 370 380 390
THPSYGDYWI VKNSWGTDWG KDGYVYMARN RGNMCHIASA ASFPI
Length:395
Mass (Da):44,549
Last modified:January 1, 1998 - v1
Checksum:i6EC65C20333BE2D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031819 mRNA. Translation: AAB86867.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031819 mRNA. Translation: AAB86867.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BMUmodel-A182-395[»]
ProteinModelPortaliO17473.
SMRiO17473. Positions 182-395.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cathepsin L-like cysteine protease from Brugia pahangi third stage larvae."
    Selzer P.M., Huong X., Britton C., McKerrow J.H.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular model of Brugia pahangi third-stage larvae cysteine protease."
    Selzer P.M., Chen X., Cohen F.E., McKerrow J.H.
    Submitted (JUL-1998) to the PDB data bank
    Cited for: 3D-STRUCTURE MODELING OF 182-395, DISULFIDE BONDS.

Entry informationi

Entry nameiCATL_BRUPA
AccessioniPrimary (citable) accession number: O17473
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: November 26, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.