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O17473

- CATL_BRUPA

UniProt

O17473 - CATL_BRUPA

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Protein
Cathepsin L-like
Gene
N/A
Organism
Brugia pahangi (Filarial nematode worm)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei206 – 2061 By similarity
Active sitei342 – 3421 By similarity
Active sitei363 – 3631 By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Names & Taxonomyi

Protein namesi
Recommended name:
Cathepsin L-like (EC:3.4.22.15)
OrganismiBrugia pahangi (Filarial nematode worm)
Taxonomic identifieri6280 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaSpiruridaFilarioideaOnchocercidaeBrugia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616 Reviewed prediction
Add
BLAST
Propeptidei17 – 181165Activation peptide Reviewed prediction
PRO_0000026293Add
BLAST
Chaini182 – 395214Cathepsin L-like
PRO_0000026294Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi203 ↔ 2461 Publication
Disulfide bondi237 ↔ 2781 Publication
Disulfide bondi337 ↔ 3851 Publication

Keywords - PTMi

Disulfide bond, Zymogen

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni188 – 1925
Beta strandi202 – 2043
Helixi206 – 22318
Helixi231 – 2377
Helixi251 – 2588
Beta strandi259 – 2613
Turni266 – 2683
Beta strandi279 – 2835
Helixi300 – 31011
Beta strandi313 – 3164
Helixi322 – 3265
Beta strandi343 – 3497
Beta strandi358 – 3625
Beta strandi367 – 3693
Beta strandi374 – 3785
Helixi384 – 3863

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BMUmodel-A182-395[»]
ProteinModelPortaliO17473.
SMRiO17473. Positions 182-395.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O17473-1 [UniParc]FASTAAdd to Basket

« Hide

MWTIAQLAVF AILALADFAV AGEIEQLKEV LGKFNKDYKQ GNMTRLASDF    50
RSALKEYGDG QQGESTVVQE FLKKTEDNGE QRAMEKLETE WKDYVTALGK 100
HYDQKENNFR MAIFESNELM TERINKKYEQ GLVSYTTALN DLADLTDEEF 150
MVRNGLRLPN QTDLRGKRQT SEFYRYDKSE RLPDQVDWRT KGAVTPVRNQ 200
GECGSCYAFA TAAALEAYHK QMTGRLLDLS PQNIVDCTRN LGNNGCSGGY 250
MPTAFQYASR YGIAMESRYP YVGTEQRCRW QQSIAVVTDN GFNEIQPGDE 300
LALKHAVAKR GPVVVGISGS KRSFRFYKDG VYSEGNCGRP DHAVLAVGYG 350
THPSYGDYWI VKNSWGTDWG KDGYVYMARN RGNMCHIASA ASFPI 395
Length:395
Mass (Da):44,549
Last modified:January 1, 1998 - v1
Checksum:i6EC65C20333BE2D1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF031819 mRNA. Translation: AAB86867.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF031819 mRNA. Translation: AAB86867.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1BMU model - A 182-395 [» ]
ProteinModelPortali O17473.
SMRi O17473. Positions 182-395.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view ]
PANTHERi PTHR12411. PTHR12411. 1 hit.
Pfami PF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view ]
PRINTSi PR00705. PAPAIN.
SMARTi SM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view ]
PROSITEi PS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cathepsin L-like cysteine protease from Brugia pahangi third stage larvae."
    Selzer P.M., Huong X., Britton C., McKerrow J.H.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular model of Brugia pahangi third-stage larvae cysteine protease."
    Selzer P.M., Chen X., Cohen F.E., McKerrow J.H.
    Submitted (JUL-1998) to the PDB data bank
    Cited for: 3D-STRUCTURE MODELING OF 182-395, DISULFIDE BONDS.

Entry informationi

Entry nameiCATL_BRUPA
AccessioniPrimary (citable) accession number: O17473
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: May 14, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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