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Protein
Submitted name:

SERotonin/octopamine receptor family

Gene

ser-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • amine binding Source: WormBase
  • G-protein coupled serotonin receptor activity Source: WormBase
  • serotonin binding Source: WormBase

GO - Biological processi

  • calcium-mediated signaling Source: WormBase
  • male mating behavior Source: WormBase
  • oviposition Source: WormBase
  • response to heat Source: WormBase
  • serotonin receptor signaling pathway Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorUniRule annotation, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-CEL-390666. Serotonin receptors.

Names & Taxonomyi

Protein namesi
Submitted name:
SERotonin/octopamine receptor familyImported
Submitted name:
Serotonin receptorImported
Gene namesi
Name:ser-1Imported
Synonyms:5-HT2CeLImported
ORF Names:CELE_F59C12.2Imported, F59C12.2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF59C12.2a; CE28481; WBGene00004776; ser-1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei57 – 8024HelicalSequence analysisAdd
BLAST
Transmembranei92 – 11524HelicalSequence analysisAdd
BLAST
Transmembranei121 – 15030HelicalSequence analysisAdd
BLAST
Transmembranei171 – 19424HelicalSequence analysisAdd
BLAST
Transmembranei214 – 23522HelicalSequence analysisAdd
BLAST
Transmembranei373 – 39523HelicalSequence analysisAdd
BLAST
Transmembranei407 – 43024HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • intracellular Source: GOC
  • plasma membrane Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi6239.F59C12.2a.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini72 – 427356G_PROTEIN_RECEP_F1_2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00780000121897.
HOGENOMiHOG000020804.
KOiK04157.
OMAiNGLRRTM.
OrthoDBiEOG79KPFC.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O17470-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIELFSHSA PPEDPYYVPA NESFATTALT PHFSTTSVWS IRVQLIPTMG
60 70 80 90 100
IYHFNGVALF LLPVLCLIGL IGNFLVCVAI ATDRRLHNVT NYFLFSLALA
110 120 130 140 150
DLLVCCIVMP LSIVVEVRHG VWTWSVSMCL LYVYSDVFLC SASIVHMSVI
160 170 180 190 200
SLDRYLGISQ PLRTRNRSKT LIFIKIAIVW VVTLLVSCPI AVLAMHDTAN
210 220 230 240 250
ILRNNQCMIF SRYYIIYGST MTFLIPLCIM GVTYAKTTQL LNKQASILSQ
260 270 280 290 300
KAGDKFNGNG LRRTMPHRKL GYARTYSATV NGTIANGKAI GAHGRTMSSI
310 320 330 340 350
SNIANGETAD RLGTSRPSIN TNGHKQLQKA STINKWKSRT SNLVTNFANK
360 370 380 390 400
VGRRSSLQTA TQDLANEHKA TRVLAVVFAC FFICWTPFFF INFLIGFGGE
410 420 430 440 450
NVQIPDWVAS IFLWLGYVSS TINPIIYTVF NKRFRQAFVR ILRCQCFHPL
460 470 480 490 500
RDSHQMYSRN FTTTIVPDTY TCSRSNQERT TSVITRDETR SARSSERPEP
510 520 530 540 550
SRARSEISEE PVARTNGKLT SEKKKISLPS FPRVSSSRDS RATTEASTTD
560 570 580 590 600
EETKPLIPKS TVPATVINIP EQLINPIKKS LTTIINMPLL DETIPEKAQV
610 620 630 640 650
HHKSQTLLTS STLNFATFST CPQQPTRSYS CVDCKKAEKM LSSDVSDMMT
660 670 680
TSTASTASTV NGAPRKHLTL FNHFDSAIKE TFL
Length:683
Mass (Da):76,200
Last modified:January 1, 1998 - v1
Checksum:i7A2614F617716D4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031414 mRNA. Translation: AAC15827.1.
BX284606 Genomic DNA. Translation: CCD63419.1.
PIRiT37239.
T37240.
RefSeqiNP_001024728.1. NM_001029557.2.
UniGeneiCel.19556.

Genome annotation databases

EnsemblMetazoaiF59C12.2a; F59C12.2a; WBGene00004776.
GeneIDi181716.
KEGGicel:CELE_F59C12.2.
UCSCiF59C12.2b. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031414 mRNA. Translation: AAC15827.1.
BX284606 Genomic DNA. Translation: CCD63419.1.
PIRiT37239.
T37240.
RefSeqiNP_001024728.1. NM_001029557.2.
UniGeneiCel.19556.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F59C12.2a.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF59C12.2a; F59C12.2a; WBGene00004776.
GeneIDi181716.
KEGGicel:CELE_F59C12.2.
UCSCiF59C12.2b. c. elegans.

Organism-specific databases

CTDi181716.
WormBaseiF59C12.2a; CE28481; WBGene00004776; ser-1.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00780000121897.
HOGENOMiHOG000020804.
KOiK04157.
OMAiNGLRRTM.
OrthoDBiEOG79KPFC.

Enzyme and pathway databases

ReactomeiR-CEL-390666. Serotonin receptors.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.
  2. "Characterization of a novel serotonin receptor from Caenorhabditis elegans: cloning and expression of two splice variants."
    Hamdan F.F., Ungrin M.D., Abramovitz M., Ribeiro P.
    J. Neurochem. 72:1372-1383(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: N2Imported.
  3. Alber B.E., Fuchs G.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Bristol N2Imported.
  4. WormBase Consortium
    WormBase
    Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiO17470_CAEEL
AccessioniPrimary (citable) accession number: O17470
Secondary accession number(s): Q21034
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: July 6, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.