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Protein
Submitted name:

SERotonin/octopamine receptor family

Gene

ser-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • amine binding Source: WormBase
  • G-protein coupled serotonin receptor activity Source: WormBase
  • neurotransmitter receptor activity Source: GO_Central
  • serotonin binding Source: WormBase

GO - Biological processi

  • calcium-mediated signaling Source: WormBase
  • male mating behavior Source: WormBase
  • oviposition Source: WormBase
  • response to heat Source: WormBase
  • serotonin receptor signaling pathway Source: WormBase

Keywordsi

Molecular functionG-protein coupled receptorUniRule annotation, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-CEL-390666 Serotonin receptors

Names & Taxonomyi

Protein namesi
Submitted name:
SERotonin/octopamine receptor familyImported
Submitted name:
Serotonin receptorImported
Gene namesi
Name:ser-1Imported
Synonyms:5-HT2CeLImported
ORF Names:CELE_F59C12.2Imported, F59C12.2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF59C12.2a ; CE28481 ; WBGene00004776 ; ser-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei57 – 80HelicalSequence analysisAdd BLAST24
Transmembranei92 – 115HelicalSequence analysisAdd BLAST24
Transmembranei121 – 150HelicalSequence analysisAdd BLAST30
Transmembranei171 – 194HelicalSequence analysisAdd BLAST24
Transmembranei214 – 235HelicalSequence analysisAdd BLAST22
Transmembranei373 – 395HelicalSequence analysisAdd BLAST23
Transmembranei407 – 430HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiWBGene00004776
ExpressionAtlasiO17470 baseline

Interactioni

Protein-protein interaction databases

IntActiO17470, 1 interactor
STRINGi6239.F59C12.2a

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 427G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST356

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00890000139331
HOGENOMiHOG000020804
KOiK04157
OMAiNGLRRTM
OrthoDBiEOG091G06VI

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O17470-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIELFSHSA PPEDPYYVPA NESFATTALT PHFSTTSVWS IRVQLIPTMG
60 70 80 90 100
IYHFNGVALF LLPVLCLIGL IGNFLVCVAI ATDRRLHNVT NYFLFSLALA
110 120 130 140 150
DLLVCCIVMP LSIVVEVRHG VWTWSVSMCL LYVYSDVFLC SASIVHMSVI
160 170 180 190 200
SLDRYLGISQ PLRTRNRSKT LIFIKIAIVW VVTLLVSCPI AVLAMHDTAN
210 220 230 240 250
ILRNNQCMIF SRYYIIYGST MTFLIPLCIM GVTYAKTTQL LNKQASILSQ
260 270 280 290 300
KAGDKFNGNG LRRTMPHRKL GYARTYSATV NGTIANGKAI GAHGRTMSSI
310 320 330 340 350
SNIANGETAD RLGTSRPSIN TNGHKQLQKA STINKWKSRT SNLVTNFANK
360 370 380 390 400
VGRRSSLQTA TQDLANEHKA TRVLAVVFAC FFICWTPFFF INFLIGFGGE
410 420 430 440 450
NVQIPDWVAS IFLWLGYVSS TINPIIYTVF NKRFRQAFVR ILRCQCFHPL
460 470 480 490 500
RDSHQMYSRN FTTTIVPDTY TCSRSNQERT TSVITRDETR SARSSERPEP
510 520 530 540 550
SRARSEISEE PVARTNGKLT SEKKKISLPS FPRVSSSRDS RATTEASTTD
560 570 580 590 600
EETKPLIPKS TVPATVINIP EQLINPIKKS LTTIINMPLL DETIPEKAQV
610 620 630 640 650
HHKSQTLLTS STLNFATFST CPQQPTRSYS CVDCKKAEKM LSSDVSDMMT
660 670 680
TSTASTASTV NGAPRKHLTL FNHFDSAIKE TFL
Length:683
Mass (Da):76,200
Last modified:January 1, 1998 - v1
Checksum:i7A2614F617716D4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031414 mRNA Translation: AAC15827.1
BX284606 Genomic DNA Translation: CCD63419.1
PIRiT37239
T37240
RefSeqiNP_001024728.1, NM_001029557.2
UniGeneiCel.19556

Genome annotation databases

EnsemblMetazoaiF59C12.2a; F59C12.2a; WBGene00004776
GeneIDi181716
KEGGicel:CELE_F59C12.2
UCSCiF59C12.2b c. elegans

Similar proteinsi

Entry informationi

Entry nameiO17470_CAEEL
AccessioniPrimary (citable) accession number: O17470
Secondary accession number(s): Q21034
Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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