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Protein

26S proteasome non-ATPase regulatory subunit 4

Gene
N/A
Organism
Schistosoma mansoni (Blood fluke)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Binds and presumably selects ubiquitin-conjugates for destruction.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome non-ATPase regulatory subunit 4
Alternative name(s):
26S proteasome regulatory subunit RPN10
26S proteasome regulatory subunit S5A
OrganismiSchistosoma mansoni (Blood fluke)
Taxonomic identifieri6183 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001738311 – 42026S proteasome non-ATPase regulatory subunit 4Add BLAST420

Expressioni

Gene expression databases

ExpressionAtlasiO17453. differential.

Interactioni

Subunit structurei

The 26S proteasome is composed of a core protease, known as the 20S proteasome, capped at one or both ends by the 19S regulatory complex (RC). The RC is composed of at least 18 different subunits in two subcomplexes, the base and the lid, which form the portions proximal and distal to the 20S proteolytic core, respectively (By similarity).By similarity

Protein-protein interaction databases

STRINGi6183.Smp_000740.2__mRNA.

Structurei

3D structure databases

ProteinModelPortaliO17453.
SMRiO17453.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 174VWFAAdd BLAST174
Domaini210 – 229UIM 1PROSITE-ProRule annotationAdd BLAST20
Domaini255 – 274UIM 2PROSITE-ProRule annotationAdd BLAST20
Domaini288 – 307UIM 3PROSITE-ProRule annotationAdd BLAST20

Sequence similaritiesi

Belongs to the proteasome subunit S5A family.Curated
Contains 3 UIM (ubiquitin-interacting motif) domains.PROSITE-ProRule annotation
Contains 1 VWFA domain.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2884. Eukaryota.
COG5148. LUCA.
HOGENOMiHOG000165630.
OMAiDETNAPM.
OrthoDBiEOG091G0A6L.
PhylomeDBiO17453.

Family and domain databases

InterProiIPR027040. Proteasome_su_Rpn10.
IPR003903. UIM_dom.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR10223. PTHR10223. 2 hits.
PfamiPF02809. UIM. 3 hits.
PF13519. VWA_2. 1 hit.
[Graphical view]
SMARTiSM00726. UIM. 3 hits.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS50330. UIM. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O17453-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQEATIIAV DNSDYMRNGD FFPTRLQAQN DAVGLICQSK RQRNPENTIG
60 70 80 90 100
LLSLANTEVL CTLTNDVSKI YNRLHLVEPK GRIIFCSSIR IAHLALRHRQ
110 120 130 140 150
LRHQKMRIVC FIGSPILEDE KELTRLAKRL KKEKVNVDII NFGENETNEQ
160 170 180 190 200
KLSEFIDTLN GKDGTGSHLI SVAPGTVLHD TLMTSPVVAG EDGSGMAGAG
210 220 230 240 250
LGLEFGLDGA EDPDLLYALR VSMEDQRMRQ EHEVNGDGSN TSVVATSLPA
260 270 280 290 300
GSGTSEEAML QQALAMSMQM NNTESSSLPM DIDLAAMSEE DQIAYALRMS
310 320 330 340 350
LQQMGEETTQ PTTTTLESDK TIVEPSGVAM DIDQTPTKVT ENPNLSSSSG
360 370 380 390 400
TLAAATSAVP TSADLDVMYD AEFLESVLQS LPGVDTQNED VRKAINALTK
410 420
SQSQRGSKKD EKEDEDKQNS
Length:420
Mass (Da):45,728
Last modified:December 15, 1998 - v2
Checksum:i441F8D0303B7ACD1
GO

Sequence cautioni

The sequence AAB86561 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030960 mRNA. Translation: AAB86561.1. Different initiation.

Genome annotation databases

EnsemblMetazoaiSmp_000740.2; Smp_000740.2:pep; Smp_000740.
GeneDBiSmp_000740.1:pep.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030960 mRNA. Translation: AAB86561.1. Different initiation.

3D structure databases

ProteinModelPortaliO17453.
SMRiO17453.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6183.Smp_000740.2__mRNA.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiSmp_000740.2; Smp_000740.2:pep; Smp_000740.
GeneDBiSmp_000740.1:pep.

Phylogenomic databases

eggNOGiKOG2884. Eukaryota.
COG5148. LUCA.
HOGENOMiHOG000165630.
OMAiDETNAPM.
OrthoDBiEOG091G0A6L.
PhylomeDBiO17453.

Gene expression databases

ExpressionAtlasiO17453. differential.

Family and domain databases

InterProiIPR027040. Proteasome_su_Rpn10.
IPR003903. UIM_dom.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR10223. PTHR10223. 2 hits.
PfamiPF02809. UIM. 3 hits.
PF13519. VWA_2. 1 hit.
[Graphical view]
SMARTiSM00726. UIM. 3 hits.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS50330. UIM. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPSMD4_SCHMA
AccessioniPrimary (citable) accession number: O17453
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 15, 1998
Last modified: November 30, 2016
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.