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O17450

- PE48_CHRBE

UniProt

O17450 - PE48_CHRBE

Protein

Peritrophin-48

Gene
N/A
Organism
Chrysomya bezziana (Old world screw-worm fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Binds chitin and may bind related oligosaccharide structures.

    GO - Molecular functioni

    1. chitin binding Source: UniProtKB-KW

    GO - Biological processi

    1. chitin metabolic process Source: InterPro

    Keywords - Ligandi

    Chitin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peritrophin-48
    OrganismiChrysomya bezziana (Old world screw-worm fly)
    Taxonomic identifieri69364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaOestroideaCalliphoridaeChrysomyinaeChrysomya

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Add
    BLAST
    Chaini21 – 379359Peritrophin-48PRO_0000023614Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi60 ↔ 73PROSITE-ProRule annotation
    Disulfide bondi120 ↔ 133PROSITE-ProRule annotation
    Glycosylationi150 – 1501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi168 – 1681N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi185 ↔ 198PROSITE-ProRule annotation
    Glycosylationi247 – 2471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi252 – 2521N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi324 ↔ 337PROSITE-ProRule annotation
    Glycosylationi341 – 3411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi356 – 3561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi373 – 3731N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Glycosylated.

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Expressioni

    Tissue specificityi

    Larval peritrophic membrane.

    Structurei

    3D structure databases

    ProteinModelPortaliO17450.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 8359Chitin-binding type-2 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini86 – 14358Chitin-binding type-2 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini151 – 20858Chitin-binding type-2 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini224 – 28360Chitin-binding type-2 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini285 – 35672Chitin-binding type-2 5PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 5 chitin-binding type-2 domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Family and domain databases

    Gene3Di2.170.140.10. 3 hits.
    InterProiIPR002557. Chitin-bd_dom.
    [Graphical view]
    PfamiPF01607. CBM_14. 4 hits.
    [Graphical view]
    SMARTiSM00494. ChtBD2. 5 hits.
    [Graphical view]
    SUPFAMiSSF57625. SSF57625. 4 hits.
    PROSITEiPS50940. CHIT_BIND_II. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O17450-1 [UniParc]FASTAAdd to Basket

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    MKAKTLTATL ALILLAFAQA DYDVASYCQL VQSGTKLPSL DSCQNYYTCV    50
    SNGLPTLSSC SSGYVFNKDS QQCVPTGSFN CFFGVANPCQ NQDKKFVPSA 100
    KQCNEWHYCL AGAIAGTGTC KEGQIFNFAK QSCVYGECSN TGNNILDSPN 150
    LSVCQIMPNG IYFGDNKNCS TWHKCSGMEE KKGTCPNGDN FDPTYASCVP 200
    SNMPACSRIQ NPPSTGVVSG PPSTSPCSLG TVVGDLTSCS VYYKCENATR 250
    SNSTIWNTYT CSGQFFDVIS KQCTSTNQAR TLKGCNRCQF TTGSMYWVNA 300
    VDPQCSEYFT CSNGLETKST ASTCGAGNFF NEDLQYCMIG NSTVGQYAQT 350
    HGACENYTCN PNTRLCNLVT ATNTTSSHR 379
    Length:379
    Mass (Da):40,829
    Last modified:January 1, 1998 - v1
    Checksum:iFCDCC6AAE7976479
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti159 – 1591N → H in AAD25103. (PubMed:11439251)Curated
    Sequence conflicti167 – 1671K → T in AAD25103. (PubMed:11439251)Curated
    Sequence conflicti236 – 2361L → I in AAD25103. (PubMed:11439251)Curated
    Sequence conflicti263 – 2631G → S in AAD25103. (PubMed:11439251)Curated
    Sequence conflicti278 – 2781Q → P in AAD25103. (PubMed:11439251)Curated
    Sequence conflicti282 – 2821L → F in AAD25103. (PubMed:11439251)Curated
    Sequence conflicti286 – 2861N → I in AAD25103. (PubMed:11439251)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF030557 mRNA. Translation: AAB86623.1.
    AF139718 Genomic DNA. Translation: AAD25103.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF030557 mRNA. Translation: AAB86623.1 .
    AF139718 Genomic DNA. Translation: AAD25103.1 .

    3D structure databases

    ProteinModelPortali O17450.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.170.140.10. 3 hits.
    InterProi IPR002557. Chitin-bd_dom.
    [Graphical view ]
    Pfami PF01607. CBM_14. 4 hits.
    [Graphical view ]
    SMARTi SM00494. ChtBD2. 5 hits.
    [Graphical view ]
    SUPFAMi SSF57625. SSF57625. 4 hits.
    PROSITEi PS50940. CHIT_BIND_II. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and molecular characterisation of a peritrophin gene, peritrophin-48, from the myiasis fly Chrysomya bezziana."
      Vuocolo T., Eisemann C.H., Pearson R.D., Willadsen P., Tellam R.L.
      Insect Biochem. Mol. Biol. 31:919-932(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Tissue: Larval peritrophic membrane.

    Entry informationi

    Entry nameiPE48_CHRBE
    AccessioniPrimary (citable) accession number: O17450
    Secondary accession number(s): Q9XZF7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 15, 2002
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3