Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O17450

- PE48_CHRBE

UniProt

O17450 - PE48_CHRBE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Peritrophin-48

Gene
N/A
Organism
Chrysomya bezziana (Old world screw-worm fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Binds chitin and may bind related oligosaccharide structures.

GO - Molecular functioni

  1. chitin binding Source: UniProtKB-KW

GO - Biological processi

  1. chitin metabolic process Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Chitin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Peritrophin-48
OrganismiChrysomya bezziana (Old world screw-worm fly)
Taxonomic identifieri69364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaOestroideaCalliphoridaeChrysomyinaeChrysomya

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Add
BLAST
Chaini21 – 379359Peritrophin-48PRO_0000023614Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi60 ↔ 73PROSITE-ProRule annotation
Disulfide bondi120 ↔ 133PROSITE-ProRule annotation
Glycosylationi150 – 1501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi168 – 1681N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi185 ↔ 198PROSITE-ProRule annotation
Glycosylationi247 – 2471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi252 – 2521N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi324 ↔ 337PROSITE-ProRule annotation
Glycosylationi341 – 3411N-linked (GlcNAc...)Sequence Analysis
Glycosylationi356 – 3561N-linked (GlcNAc...)Sequence Analysis
Glycosylationi373 – 3731N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Larval peritrophic membrane.

Structurei

3D structure databases

ProteinModelPortaliO17450.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 8359Chitin-binding type-2 1PROSITE-ProRule annotationAdd
BLAST
Domaini86 – 14358Chitin-binding type-2 2PROSITE-ProRule annotationAdd
BLAST
Domaini151 – 20858Chitin-binding type-2 3PROSITE-ProRule annotationAdd
BLAST
Domaini224 – 28360Chitin-binding type-2 4PROSITE-ProRule annotationAdd
BLAST
Domaini285 – 35672Chitin-binding type-2 5PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 5 chitin-binding type-2 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3Di2.170.140.10. 3 hits.
InterProiIPR002557. Chitin-bd_dom.
[Graphical view]
PfamiPF01607. CBM_14. 4 hits.
[Graphical view]
SMARTiSM00494. ChtBD2. 5 hits.
[Graphical view]
SUPFAMiSSF57625. SSF57625. 4 hits.
PROSITEiPS50940. CHIT_BIND_II. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O17450-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKAKTLTATL ALILLAFAQA DYDVASYCQL VQSGTKLPSL DSCQNYYTCV
60 70 80 90 100
SNGLPTLSSC SSGYVFNKDS QQCVPTGSFN CFFGVANPCQ NQDKKFVPSA
110 120 130 140 150
KQCNEWHYCL AGAIAGTGTC KEGQIFNFAK QSCVYGECSN TGNNILDSPN
160 170 180 190 200
LSVCQIMPNG IYFGDNKNCS TWHKCSGMEE KKGTCPNGDN FDPTYASCVP
210 220 230 240 250
SNMPACSRIQ NPPSTGVVSG PPSTSPCSLG TVVGDLTSCS VYYKCENATR
260 270 280 290 300
SNSTIWNTYT CSGQFFDVIS KQCTSTNQAR TLKGCNRCQF TTGSMYWVNA
310 320 330 340 350
VDPQCSEYFT CSNGLETKST ASTCGAGNFF NEDLQYCMIG NSTVGQYAQT
360 370
HGACENYTCN PNTRLCNLVT ATNTTSSHR
Length:379
Mass (Da):40,829
Last modified:January 1, 1998 - v1
Checksum:iFCDCC6AAE7976479
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti159 – 1591N → H in AAD25103. (PubMed:11439251)Curated
Sequence conflicti167 – 1671K → T in AAD25103. (PubMed:11439251)Curated
Sequence conflicti236 – 2361L → I in AAD25103. (PubMed:11439251)Curated
Sequence conflicti263 – 2631G → S in AAD25103. (PubMed:11439251)Curated
Sequence conflicti278 – 2781Q → P in AAD25103. (PubMed:11439251)Curated
Sequence conflicti282 – 2821L → F in AAD25103. (PubMed:11439251)Curated
Sequence conflicti286 – 2861N → I in AAD25103. (PubMed:11439251)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF030557 mRNA. Translation: AAB86623.1.
AF139718 Genomic DNA. Translation: AAD25103.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF030557 mRNA. Translation: AAB86623.1 .
AF139718 Genomic DNA. Translation: AAD25103.1 .

3D structure databases

ProteinModelPortali O17450.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.170.140.10. 3 hits.
InterProi IPR002557. Chitin-bd_dom.
[Graphical view ]
Pfami PF01607. CBM_14. 4 hits.
[Graphical view ]
SMARTi SM00494. ChtBD2. 5 hits.
[Graphical view ]
SUPFAMi SSF57625. SSF57625. 4 hits.
PROSITEi PS50940. CHIT_BIND_II. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification and molecular characterisation of a peritrophin gene, peritrophin-48, from the myiasis fly Chrysomya bezziana."
    Vuocolo T., Eisemann C.H., Pearson R.D., Willadsen P., Tellam R.L.
    Insect Biochem. Mol. Biol. 31:919-932(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Larval peritrophic membrane.

Entry informationi

Entry nameiPE48_CHRBE
AccessioniPrimary (citable) accession number: O17450
Secondary accession number(s): Q9XZF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: January 1, 1998
Last modified: October 1, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3