Reviewed, UniProtKB/Swiss-Prot O17446 (TY3H_SCHMA)

Names and origin

Protein names

Recommended name:
    Tyrosine 3-monooxygenase
    EC=1.14.16.2
Alternative name(s):
    Tyrosine 3-hydroxylase
      Short name=TH

Gene names

Name:

TH

Organism

Schistosoma mansoni (Blood fluke)

Taxonomic identifier

6183 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Platyhelminthes › Trematoda › Digenea › Strigeidida › Schistosomatoidea › Schistosomatidae › Schistosoma

Protein attributes

Sequence length	465 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin.
Cofactor	Fe2+ ion.
Pathway	Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 1/2.
Sequence similarities	Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

Ontologies

Keywords
Biological process	Catecholamine biosynthesis Neurotransmitter biosynthesis
Ligand	Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Gene Ontology (GO)
Biological process	aromatic amino acid family metabolic process Inferred from electronic annotation. Source: InterPro catecholamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW neurotransmitter biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW tyrosine 3-monooxygenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 465	465	Tyrosine 3-monooxygenase		PRO_0000205567
Sites
	Metal binding	294	1	Iron By similarity
	Metal binding	299	1	Iron By similarity
	Metal binding	339	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	O17446-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 0DE47B4A474665CB	FASTA	465	54,081
	10 20 30 40 50 60 MKMTMMCDES IEENNKSSTV ELNHNEKDGR IHSIIINFHP ITHEQSNNQF YIQTLHEILK 70 80 90 100 110 120 YIIDKKLNLV HFETRPTLTL SNANRDVQYS CLITLEANEI NMSLLYEELR GNSFISGINL 130 140 150 160 170 180 LNNQESEDWY PKHISDLDKC QHLLRKFQPE LQTDHPGFHD KVYRERREAI AKIAFQYKYG 190 200 210 220 230 240 DRIPEVEYTK EEIETWGLVF TKMKAVHASR ACREYIDGFQ LLEKYCNYNS ESIPQLQTIC 250 260 270 280 290 300 EFMHRTSGFR IRPVAGLVSP KDFLASLAFR VFQCTQYIRH HSRPMHTPEP DCIHELIGHM 310 320 330 340 350 360 PMLVNRQFAD FSQELGLASL GASEEEITRL STLYWFTVEF GLCNENGETR ALGAGIMSSY 370 380 390 400 410 420 GELENAFSDL SVKEPFNIND AAVQVYDDVG YQKIYFVTES IESMKRELRN YINTSGKSTI 430 440 450 460 PIYDPITETV HMKSRFSIRK ELLKHVKEEI GQLDTLLNHS NYTLP

References

[1]	"Cloning and characterization of a novel form of tyrosine hydroxylase from the human parasite, Schistosoma mansoni." Hamdan F.F., Ribeiro P. J. Neurochem. 71:1369-1380(1998) [PubMed: 9751167] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Puerto Rican.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF030336 mRNA. Translation: AAC62256.1.
3D structure databases
SMR	O17446. Positions 128-459.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.14.16.2. 1460.
Family and domain databases
InterPro	IPR001273. ArAA_hydroxylase. IPR018301. ArAA_hydroxylase_Fe/CU_BS. IPR019774. Aromatic-AA_hydroxylase_C. IPR005962. Tyr_3_mOase. IPR019773. Tyrosine_3-monooxygenase-like. [Graphical view]
Gene3D	G3DSA:1.10.800.10. Aaa_hydroxylase. 1 hit.
PANTHER	PTHR11473. Aaa_hydroxylase. 1 hit.
Pfam	PF00351. Biopterin_H. 1 hit. [Graphical view]
PIRSF	PIRSF000336. TH. 1 hit.
PRINTS	PR00372. FYWHYDRXLASE.
TIGRFAMs	TIGR01269. Tyr_3_monoox. 1 hit.
PROSITE	PS00367. BIOPTERIN_HYDROXYL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TY3H_SCHMA

Accession

Primary (citable) accession number: O17446

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	January 1, 1998
Last modified:	February 9, 2010
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)