ID   1CPX_DIRIM              Reviewed;         235 AA.
AC   O17433;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   16-JUN-2009, entry version 46.
DE   RecName: Full=1-Cys peroxiredoxin;
DE            EC=1.11.1.15;
DE   AltName: Full=Thioredoxin peroxidase;
DE   AltName: Full=1-CysPxn;
OS   Dirofilaria immitis (Canine heartworm).
OC   Eukaryota; Metazoa; Nematoda; Chromadorea; Spirurida; Filarioidea;
OC   Onchocercidae; Dirofilaria.
OX   NCBI_TaxID=6287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   McGonigle S., James E.R.;
RT   "1-Cys peroxidoxin from Dirofilaria immitis.";
RL   Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Thiol specific antioxidant.
CC   -!- CATALYTIC ACTIVITY: 2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- PTM: Cys-49 is the site of oxidation by H(2)O(2). The oxidized
CC       intermediate might be Cys-SOH (By similarity).
CC   -!- SIMILARITY: Belongs to the ahpC/TSA family. Rehydrin subfamily.
CC   -!- SIMILARITY: Contains 1 thioredoxin domain.
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DR   EMBL; AF027387; AAB83998.1; -; mRNA.
DR   HSSP; P30041; 1PRX.
DR   PeroxiBase; 4935; Di1CysPrx.
DR   BRENDA; 1.11.1.15; 260127.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0051920; F:peroxiredoxin activity; IEA:EC.
DR   GO; GO:0045454; P:cell redox homeostasis; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR000866; Alkyl_hydroperoxide_Rdtase.
DR   InterPro; IPR019479; Peroxiredoxin_C.
DR   InterPro; IPR017936; Thioredoxin-like.
DR   InterPro; IPR012335; Thioredoxin_fold.
DR   Gene3D; G3DSA:3.40.30.10; Thioredoxin_fold; 1.
DR   Pfam; PF10417; 1-cysPrx_C; 1.
DR   Pfam; PF00578; AhpC-TSA; 1.
DR   PROSITE; PS51352; THIOREDOXIN_2; 1.
PE   2: Evidence at transcript level;
KW   Antioxidant; Cytoplasm; Oxidoreductase; Peroxidase;
KW   Redox-active center.
FT   CHAIN         1    235       1-Cys peroxiredoxin.
FT                                /FTId=PRO_0000135106.
FT   DOMAIN        5    179       Thioredoxin.
FT   ACT_SITE     49     49       By similarity.
SQ   SEQUENCE   235 AA;  26342 MW;  BCC198C87D88FD97 CRC64;
     MTKGILLGDK FPDFRAETNE GFIPSFYDWI GKDSWAILFS HPRDFTPVCT TELARLVQLA
     PEFNKRNVKL IGLSCDSAES HRKWVDDIMA VCKMKCNDGD TCCSGNKLPF PIIADENRFL
     ATELGMMDPD ERDENGNALT ARCVFIIGPE KTLKLSILYP ATTGRNFDEI LRVVDSLQLT
     AVKLVATPVD WKDGDDCVVL PTIDDTEAKK LFGEKINTIE LPSGKHYLRM VAHPK
//