Reviewed, UniProtKB/Swiss-Prot O17433 (1CPX_DIRIM)

Names and origin

Protein names	Recommended name:     1-Cys peroxiredoxin     EC=1.11.1.15 Alternative name(s):     Thioredoxin peroxidase     1-CysPxn
Organism	Dirofilaria immitis (Canine heartworm)
Taxonomic identifier	6287 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Nematoda › Chromadorea › Spirurida › Filarioidea › Onchocercidae › Dirofilaria

Protein attributes

Sequence length	235 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Thiol specific antioxidant.
Catalytic activity	2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.
Subcellular location	Cytoplasm By similarity.
Post-translational modification	Cys-49 is the site of oxidation by H2O2. The oxidized intermediate might be Cys-SOH By similarity.
Sequence similarities	Belongs to the ahpC/TSA family. Rehydrin subfamily. Contains 1 thioredoxin domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	Redox-active center
Molecular function	Antioxidant Oxidoreductase Peroxidase
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	peroxiredoxin activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 235	235	1-Cys peroxiredoxin		PRO_0000135106
Regions
	Domain	5 – 179	175	Thioredoxin
Sites
	Active site	49	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	O17433-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: BCC198C87D88FD97	FASTA	235	26,342
	10 20 30 40 50 60 MTKGILLGDK FPDFRAETNE GFIPSFYDWI GKDSWAILFS HPRDFTPVCT TELARLVQLA 70 80 90 100 110 120 PEFNKRNVKL IGLSCDSAES HRKWVDDIMA VCKMKCNDGD TCCSGNKLPF PIIADENRFL 130 140 150 160 170 180 ATELGMMDPD ERDENGNALT ARCVFIIGPE KTLKLSILYP ATTGRNFDEI LRVVDSLQLT 190 200 210 220 230 AVKLVATPVD WKDGDDCVVL PTIDDTEAKK LFGEKINTIE LPSGKHYLRM VAHPK

References

[1]	"1-Cys peroxidoxin from Dirofilaria immitis." McGonigle S., James E.R. Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF027387 mRNA. Translation: AAB83998.1.
3D structure databases
HSSP	HSSP built from PDB template 1PRX based on UniProtKB P30041.
ModBase	Search...
Protein family/group databases
PeroxiBase	4935. Di1CysPrx.
Enzyme and pathway databases
BRENDA	1.11.1.15. 260127.
Family and domain databases
InterPro	IPR000866. Alkyl_hydroperoxide_Rdtase. IPR019479. Peroxiredoxin_C. IPR017936. Thioredoxin-like. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF10417. 1-cysPrx_C. 1 hit. PF00578. AhpC-TSA. 1 hit. [Graphical view]
PROSITE	PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

1CPX_DIRIM

Accession

Primary (citable) accession number: O17433

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	January 1, 1998
Last modified:	June 16, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)