O17386 (CED8_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cell death abnormality protein 8

Gene names

Name:	ced-8
ORF Names:	F08F1.5

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	458 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in programmed cell death/apoptosis and acts downstream or in parallel to ced-9. Not required for engulfment of germ cell corpses. Ref.1 Ref.3 Ref.4
Subcellular location	Cell membrane; Multi-pass membrane protein Ref.1.
Disruption phenotype	Delayed cell death process. Ref.3
Sequence similarities	Belongs to the XK family.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	DNA catabolic process Inferred from mutant phenotype Ref.1. Source: UniProtKB apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW embryo development Inferred from mutant phenotype Ref.3. Source: UniProtKB
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from direct assay Ref.1. Source: UniProtKB
Molecular function	transporter activity Traceable author statement Ref.1. Source: WormBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 458	458	Cell death abnormality protein 8		PRO_0000379936
Regions
	Transmembrane	46 – 66	21	Helical; Potential
	Transmembrane	78 – 98	21	Helical; Potential
	Transmembrane	124 – 144	21	Helical; Potential
	Transmembrane	220 – 240	21	Helical; Potential
	Transmembrane	275 – 295	21	Helical; Potential
	Transmembrane	318 – 338	21	Helical; Potential
	Transmembrane	354 – 374	21	Helical; Potential
	Transmembrane	379 – 399	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	O17386 [UniParc]. Last modified October 1, 2003. Version 2. Checksum: 9E04EEBB0299DB2C	FASTA	458	53,273
	10 20 30 40 50 60 MFLKKHKSKL LLVPRDEEQE DAGIVAVLTD RIPSVLLVRW FDLFCFGFAM CSYALDFFSD 70 80 90 100 110 120 IGIAIFHFWA GRYLSGSLVL AFALLPSVII NIISMVWMLD DEMHWKRRAH PRRTGTFELN 130 140 150 160 170 180 QKRFIPLSKM IVLCICQMGP LFWYYKALYY GWMFRKSSNE NTDGEKRKCF SKMVEAERDA 190 200 210 220 230 240 TLLRFFEAFL ESAPQLIIQG SIAASYFQNY YQTGTYPYWL YFQAASLLLS IISISWSVVV 250 260 270 280 290 300 QNRSLRMIRD DKVNIWPHEA VLQFCWRFLT ILARIITLVA LVLIFGINVV PLISVHLLVT 310 320 330 340 350 360 LVHVIFLQAI HIDACTHIEK LLLLINTFIH IFIPFNMVEG NTRWRYLTAY SVEFIEMMLV 370 380 390 400 410 420 CWLLPLSLNT FPYIEKVQVG VPISFIAGIA IMMMYYQFFH PNRRQLIVTQ SQEDLSLNVQ 430 440 450 KSVETLTPKL ESSLEISGEQ NTSQDLVSEL LLDVEHEN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The ced-8 gene controls the timing of programmed cell deaths in C. elegans." Stanfield G.M., Horvitz H.R. Mol. Cell 5:423-433(2000) [PubMed: 10882128] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
[3]	"Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans." Ellis R.E., Jacobson D.M., Horvitz H.R. Genetics 129:79-94(1991) [PubMed: 1936965] [Abstract] Cited for: FUNCTION, DISRUPTION PHENOTYPE.
[4]	"Genetic control of programmed cell death in the Caenorhabditis elegans hermaphrodite germline." Gumienny T.L., Lambie E., Hartwieg E., Horvitz H.R., Hengartner M.O. Development 126:1011-1022(1999) [PubMed: 9927601] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FO081089 Genomic DNA. Translation: CCD69028.1.
PIR	T32470.
RefSeq	NP_509427.2. NM_077026.5.
UniGene	Cel.11044.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	O17386.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	F08F1.5; F08F1.5; F08F1.5.
GeneID	184190.
KEGG	cel:F08F1.5.
NMPDR	fig|6239.3.peg.24016.
UCSC	F08F1.5. c. elegans.
Organism-specific databases
CTD	184190.
WormBase	F08F1.5; CE34294; WBGene00000422; ced-8.
Phylogenomic databases
eggNOG	meNOG07468.
GeneTree	EMGT00050000013798.
HOGENOM	HBG389084.
InParanoid	O17386.
OMA	ACTHIEK.
PhylomeDB	O17386.
Gene expression databases
ArrayExpress	O17386.
Family and domain databases
InterPro	IPR018629. Transport_prot_XK. [Graphical view]
Pfam	PF09815. XK-related. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	923854.

Entry information

Entry name

CED8_CAEEL

Accession

Primary (citable) accession number: O17386

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	October 1, 2003
Last modified:	December 14, 2011
This is version 66 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project