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O17323

- HDA4_CAEEL

UniProt

O17323 - HDA4_CAEEL

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Protein
Histone deacetylase 4
Gene
hda-4, hda-7, C10E2.3
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity. May be involved in muscle development.

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei608 – 6081 By similarity

GO - Molecular functioni

  1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC
  5. calmodulin binding Source: WormBase
  6. histone deacetylase activity Source: WormBase
  7. transcription corepressor activity Source: WormBase
  8. transcription factor binding Source: WormBase

GO - Biological processi

  1. apoptotic process Source: WormBase
  2. cellular response to DNA damage stimulus Source: WormBase
  3. chromatin modification Source: WormBase
  4. growth Source: WormBase
  5. histone deacetylation Source: WormBase
  6. intracellular signal transduction Source: WormBase
  7. locomotion Source: WormBase
  8. negative regulation of transcription from RNA polymerase II promoter Source: WormBase
  9. post-embryonic body morphogenesis Source: WormBase
  10. regulation of neuron differentiation Source: WormBase
  11. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 4 (EC:3.5.1.98)
Alternative name(s):
CeHDA-7
Histone deacetylase 7
Gene namesi
Name:hda-4
Synonyms:hda-7
ORF Names:C10E2.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome X

Organism-specific databases

WormBaseiC10E2.3a; CE42060; WBGene00001837; hda-4.
C10E2.3b; CE37192; WBGene00001837; hda-4.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. cytoplasm Source: WormBase
  2. histone deacetylase complex Source: WormBase
  3. nucleus Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 869869Histone deacetylase 4
PRO_0000114742Add
BLAST

Proteomic databases

PaxDbiO17323.

Expressioni

Tissue specificityi

Expressed in body-wall muscle cells, hypodermal seam cells and neuronal cells including sensory amphid neuronal processes, the nerve ring, ventral nerve cords and motor neuronal commissures.1 Publication

Interactioni

Subunit structurei

Isoform b interacts with mef-2.1 Publication

Protein-protein interaction databases

IntActiO17323. 1 interaction.
MINTiMINT-4299370.
STRINGi6239.C10E2.3.

Structurei

3D structure databases

ProteinModelPortaliO17323.
SMRiO17323. Positions 461-834.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni460 – 802343Histone deacetylase
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi80 – 867Poly-Gln
Compositional biasi857 – 86812Gln-rich
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0123.
GeneTreeiENSGT00530000062809.
HOGENOMiHOG000112870.
KOiK11406.
OMAiNGFACIR.
OrthoDBiEOG7RFTH5.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PRINTSiPR01270. HDASUPER.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform a (identifier: O17323-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEEASSSTGS AGGAGPSVPN LPSTSEAAIG QTNLEPESIA LLQSQLQEYR    50
QKQMDLIGHF QRAQQELSVQ HMHNLYAALQ QQQQLQNLQT ERSAVNPLLI 100
SQQHSTEDQN SGPAAPLSLA NSLTNLLSSS NGNLSVPQTP TKEHHPTAPT 150
SNRKCDLPRS NSTTISQLTK DRLKNMIANR SKGESNSQSN LMSNSVTANG 200
NGHDNGRKLK NSNSQVNVSS PHFEPYRLPT SLANAHNLQQ ASEFQLRKVN 250
SEPNLKMRIR AKLLSKGSSP VQHVQQNNSQ FNFTHPQLKR SDSETSQNVP 300
LDFMQSSSQT NLPHLMLPSP SLPNLAAAGA FHGLNLPVGQ DLNAFMAVAN 350
LSPFLSLPSL LNKKLELGGL TDEGDRNGLI GSSSTSSLAS NVSMGSHQYQ 400
SLLKQQIRDL VLRRKSLVRE DPEGEGLAEL YNGLLPQAKL QQLQALAAES 450
GFLAKQEPTC TTGLGYDQAM VRHECCCGNN ASHVENGGRI QSIWSKLIEH 500
GHVQKCEKVT AKKASLEQLQ LVHSQTYTTF FAVSPTACLK IDANSLPLKR 550
FLQLPCGGIG VDSDTYFNDA STQTAARLAA GTLIELSSQV AEGRLKNGFA 600
CIRPPGHHAE HEQAMGFCFF NNVAVAVKVL QTKYPAQCAK IAIIDWDVHH 650
GNGTQLSFEN DPNVLYMSLH RHDKGNFFPG TGSVTEVGKN DAKGLTVNVP 700
FSGDVMRDPE YLAAWRTVIE PVMASFCPDF IIVSAGFDAC HGHPNALGGY 750
EVTPEMFGYM TKSLLNYASG KVVLALEGGY DLKSISEAAQ QCVQALIGES 800
DDAGRLSSVA LESLPNPSAV ETLQKVIAIH KSYWPALHGQ EAAINTTEMQ 850
WRNLKLQVQM QQQQQQQQT 869

Note: No experimental confirmation available.

Length:869
Mass (Da):94,411
Last modified:October 3, 2012 - v3
Checksum:i0F186275170F82C3
GO
Isoform b (identifier: O17323-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.

Show »
Length:816
Mass (Da):88,982
Checksum:iDB4E641C91546161
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5353Missing in isoform b.
VSP_044209Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080490, FO080492 Genomic DNA. Translation: CCD64116.1.
FO080490, FO080492 Genomic DNA. Translation: CCF23337.1.
PIRiT32425.
RefSeqiNP_001257278.1. NM_001270349.1. [O17323-1]
NP_001257279.1. NM_001270350.1. [O17323-2]
UniGeneiCel.36427.

Genome annotation databases

EnsemblMetazoaiC10E2.3a; C10E2.3a; WBGene00001837. [O17323-1]
GeneIDi181723.
KEGGicel:CELE_C10E2.3.
UCSCiC10E2.3. c. elegans. [O17323-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080490 , FO080492 Genomic DNA. Translation: CCD64116.1 .
FO080490 , FO080492 Genomic DNA. Translation: CCF23337.1 .
PIRi T32425.
RefSeqi NP_001257278.1. NM_001270349.1. [O17323-1 ]
NP_001257279.1. NM_001270350.1. [O17323-2 ]
UniGenei Cel.36427.

3D structure databases

ProteinModelPortali O17323.
SMRi O17323. Positions 461-834.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O17323. 1 interaction.
MINTi MINT-4299370.
STRINGi 6239.C10E2.3.

Proteomic databases

PaxDbi O17323.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai C10E2.3a ; C10E2.3a ; WBGene00001837 . [O17323-1 ]
GeneIDi 181723.
KEGGi cel:CELE_C10E2.3.
UCSCi C10E2.3. c. elegans. [O17323-1 ]

Organism-specific databases

CTDi 181723.
WormBasei C10E2.3a ; CE42060 ; WBGene00001837 ; hda-4.
C10E2.3b ; CE37192 ; WBGene00001837 ; hda-4.

Phylogenomic databases

eggNOGi COG0123.
GeneTreei ENSGT00530000062809.
HOGENOMi HOG000112870.
KOi K11406.
OMAi NGFACIR.
OrthoDBi EOG7RFTH5.

Miscellaneous databases

NextBioi 915090.

Family and domain databases

Gene3Di 3.40.800.20. 1 hit.
InterProi IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PRINTSi PR01270. HDASUPER.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of CeHDA-7, a class II histone deacetylase interacting with MEF-2 in Caenorhabditis elegans."
    Choi K.Y., Ji Y.J., Jee C., Kim do H., Ahnn J.
    Biochem. Biophys. Res. Commun. 293:1295-1300(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B), TISSUE SPECIFICITY, INTERACTION WITH MEF-2.
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.

Entry informationi

Entry nameiHDA4_CAEEL
AccessioniPrimary (citable) accession number: O17323
Secondary accession number(s): H1ZUW2, Q400M0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: October 3, 2012
Last modified: June 11, 2014
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi