O17323 (HDA4_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histone deacetylase 4
EC=3.5.1.98

Alternative name(s):
CeHDA-7
Histone deacetylase 7

Gene names

Name:	hda-4
Synonyms:	hda-7
ORF Names:	C10E2.3

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	816 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity. May be involved in muscle development.
Catalytic activity	Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
Subunit structure	Interacts with mef-2. Ref.1
Subcellular location	Nucleus Probable.
Tissue specificity	Expressed in body-wall muscle cells, hypodermal seam cells and neuronal cells including sensory amphid neuronal processes, the nerve ring, ventral nerve cords and motor neuronal commissures. Ref.1
Sequence similarities	Belongs to the histone deacetylase family. HD type 2 subfamily.
Sequence caution	The sequence CCD64119.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Molecular function	Chromatin regulator Hydrolase Repressor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NAD-dependent histone deacetylase activity (H3-K14 specific) Inferred from electronic annotation. Source: EC NAD-dependent histone deacetylase activity (H3-K9 specific) Inferred from electronic annotation. Source: EC NAD-dependent histone deacetylase activity (H4-K16 specific) Inferred from electronic annotation. Source: EC histone deacetylase activity (H3-K16 specific) Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 816	816	Histone deacetylase 4		PRO_0000114742
Regions
	Region	407 – 749	343	Histone deacetylase
	Compositional bias	27 – 33	7	Poly-Gln
	Compositional bias	804 – 815	12	Gln-rich
Sites
	Active site	555	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	O17323 [UniParc]. Last modified May 16, 2003. Version 2. Checksum: DB4E641C91546161	FASTA	816	88,982
	10 20 30 40 50 60 MDLIGHFQRA QQELSVQHMH NLYAALQQQQ QLQNLQTERS AVNPLLISQQ HSTEDQNSGP 70 80 90 100 110 120 AAPLSLANSL TNLLSSSNGN LSVPQTPTKE HHPTAPTSNR KCDLPRSNST TISQLTKDRL 130 140 150 160 170 180 KNMIANRSKG ESNSQSNLMS NSVTANGNGH DNGRKLKNSN SQVNVSSPHF EPYRLPTSLA 190 200 210 220 230 240 NAHNLQQASE FQLRKVNSEP NLKMRIRAKL LSKGSSPVQH VQQNNSQFNF THPQLKRSDS 250 260 270 280 290 300 ETSQNVPLDF MQSSSQTNLP HLMLPSPSLP NLAAAGAFHG LNLPVGQDLN AFMAVANLSP 310 320 330 340 350 360 FLSLPSLLNK KLELGGLTDE GDRNGLIGSS STSSLASNVS MGSHQYQSLL KQQIRDLVLR 370 380 390 400 410 420 RKSLVREDPE GEGLAELYNG LLPQAKLQQL QALAAESGFL AKQEPTCTTG LGYDQAMVRH 430 440 450 460 470 480 ECCCGNNASH VENGGRIQSI WSKLIEHGHV QKCEKVTAKK ASLEQLQLVH SQTYTTFFAV 490 500 510 520 530 540 SPTACLKIDA NSLPLKRFLQ LPCGGIGVDS DTYFNDASTQ TAARLAAGTL IELSSQVAEG 550 560 570 580 590 600 RLKNGFACIR PPGHHAEHEQ AMGFCFFNNV AVAVKVLQTK YPAQCAKIAI IDWDVHHGNG 610 620 630 640 650 660 TQLSFENDPN VLYMSLHRHD KGNFFPGTGS VTEVGKNDAK GLTVNVPFSG DVMRDPEYLA 670 680 690 700 710 720 AWRTVIEPVM ASFCPDFIIV SAGFDACHGH PNALGGYEVT PEMFGYMTKS LLNYASGKVV 730 740 750 760 770 780 LALEGGYDLK SISEAAQQCV QALIGESDDA GRLSSVALES LPNPSAVETL QKVIAIHKSY 790 800 810 WPALHGQEAA INTTEMQWRN LKLQVQMQQQ QQQQQT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of CeHDA-7, a class II histone deacetylase interacting with MEF-2 in Caenorhabditis elegans." Choi K.Y., Ji Y.J., Jee C., Kim do H., Ahnn J. Biochem. Biophys. Res. Commun. 293:1295-1300(2002) [PubMed: 12054517] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, INTERACTION WITH MEF-2. Strain: Bristol N2.
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FO080492 Genomic DNA. Translation: CCD64119.1. Sequence problems.
PIR	T32425.
RefSeq	NP_510700.3. NM_078299.4.
3D structure databases
ProteinModelPortal	O17323.
SMR	O17323. Positions 3-43, 408-785.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-4299370.
STRING	O17323.
Proteomic databases
PRIDE	O17323.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	181723.
UCSC	C10E2.3. c. elegans.
Phylogenomic databases
eggNOG	meNOG04142.
HOGENOM	HBG388504.
OMA	NGFACIR.
PhylomeDB	O17323.
Gene expression databases
ArrayExpress	O17323.
Family and domain databases
InterPro	IPR000286. His_deacetylse. IPR023801. His_deacetylse_dom. [Graphical view]
Gene3D	G3DSA:3.40.800.20. His_deacetylse. 1 hit.
PANTHER	PTHR10625. His_deacetylse. 1 hit.
Pfam	PF00850. Hist_deacetyl. 1 hit. [Graphical view]
PRINTS	PR01270. HDASUPER.
ProtoNet	Search...

Entry information

Entry name

HDA4_CAEEL

Accession

Primary (citable) accession number: O17323

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2003
Last sequence update:	May 16, 2003
Last modified:	January 25, 2012
This is version 76 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project