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Protein

Calcium-transporting ATPase

Gene

SERCA

Organism
Procambarus clarkii (Red swamp crayfish)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.UniRule annotation

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotation

Keywords - Biological processi

Calcium transportUniRule annotation, Ion transport, Transport

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Calcium, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-transporting ATPaseUniRule annotation (EC:3.6.3.8UniRule annotation)
Gene namesi
Name:SERCAImported
OrganismiProcambarus clarkii (Red swamp crayfish)Imported
Taxonomic identifieri6728 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMalacostracaEumalacostracaEucaridaDecapodaPleocyemataAstacideaAstacoideaCambaridaeProcambarus

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei57 – 76HelicalUniRule annotationAdd BLAST20
Transmembranei88 – 107HelicalUniRule annotationAdd BLAST20
Transmembranei292 – 321HelicalUniRule annotationAdd BLAST30
Transmembranei760 – 781HelicalUniRule annotationAdd BLAST22
Transmembranei833 – 857HelicalUniRule annotationAdd BLAST25
Transmembranei928 – 950HelicalUniRule annotationAdd BLAST23
Transmembranei956 – 980HelicalUniRule annotationAdd BLAST25
Transmembranei1001 – 1019HelicalUniRule annotationAdd BLAST19

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiO17314.

Structurei

3D structure databases

ProteinModelPortaliO17314.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 77Cation_ATPase_NInterPro annotationAdd BLAST75

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR005782. P-type_ATPase_IIA.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01116. ATPase-IIA1_Ca. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O17314-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDAHCFPVE DVVAKFGVNI ENGLSASQVK DYQAKYGPNE LPAEEGKSLL
60 70 80 90 100
QLILEQFYDL LVKILLLAAI ISFVLACFEE GEETVTAFVE PFVILLILIA
110 120 130 140 150
NAIVGVWQER NAESAIEALK EYEPEMGKVV RSNKHGVQKV RAREIVPGDI
160 170 180 190 200
VEVSVGDKIP ADIRLVKIFS TTLRIDQSIL TGESVSVIKH ADAIPDPKAV
210 220 230 240 250
NQDKKNILFS GTNVSAGKAR GVVIGTGLAT AIGKIRTQMA ETEEIKTPLQ
260 270 280 290 300
QKLDEFGEQL SKVISIICVA VWAINIGHFN DPAHGGSWIK GAIYYFKIAV
310 320 330 340 350
ALAVAAIPEG LPAVITTCLA LGTRRMAKKN AIVRSLPSVE TLGCTSVICS
360 370 380 390 400
DKTGTLTTNQ MSVSRMFIMD KVEGNDSSLL EFEVTGSTYE PIGDVYLKNT
410 420 430 440 450
KVKGSDFEGL QELSTISFMC NDSSIDFNEF KNVFEKVGEA TETALIVLGE
460 470 480 490 500
KINPYNMSKS GLDRRSAAII ARHDMETKWK KEFTLEFSRD RKSMSSYCVP
510 520 530 540 550
LKPTRLGTGP KMFCKGAPEG VLDRCTHVRV GTQKVPLTAG VKEKILSVTR
560 570 580 590 600
DYGCGRDTLR CLGLATIDNP MKPEDMDLGE ASKFYTYEVN MTFVGVVGML
610 620 630 640 650
DPPRKEVKDS IQRCRDAGIR VIVITGDNKA TAEAICRRIG VFKEDEDTTG
660 670 680 690 700
MSYSGREFDE LSPEEQRQAC IRSRLFSRVE PFRKSKIVEY LQGENEISAM
710 720 730 740 750
TGDGVNDAPA LKKAEIGIAM GSGTAVAKSA SEMVLADDNF SSIVAAVEEG
760 770 780 790 800
RAIYNNMKQF IRYLISSNVG EVVSIFLTAA LGLPEALIPV QLLWVNLVTD
810 820 830 840 850
GLPATALGFN PPDLDIMDKP PRRADESLIS GWLFFRYMAI GGYVGAATVF
860 870 880 890 900
AASWWFMYDP TGPHLNYYQL SHHLQCLGDP ENFEGLDCNI FSHPAPMTMA
910 920 930 940 950
LSVLVTIEML NALNSLSENQ SLLIMPPWVN FWLLAAMALS MTLHFIILYI
960 970 980 990 1000
DILSTVFQVM PLSVAQWVAV LKISFPVLLL DETLKFIARN YTDGENNLYK
1010 1020
CHWIVLAWAT YFAYIKIYFF
Length:1,020
Mass (Da):112,493
Last modified:January 1, 1998 - v1
Checksum:i0D0E870229A78601
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025848 mRNA. Translation: AAB82290.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025848 mRNA. Translation: AAB82290.1.

3D structure databases

ProteinModelPortaliO17314.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiO17314.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR005782. P-type_ATPase_IIA.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01116. ATPase-IIA1_Ca. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO17314_PROCL
AccessioniPrimary (citable) accession number: O17314
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: October 5, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.