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O17311 (O17311_DROME) Unreviewed, UniProtKB/TrEMBL

Last modified November 16, 2011. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Proteasome subunit beta type RuleBase RU004203
EC=3.4.25.1 RuleBase RU004203
Gene names
Name:Prosbeta2 FlyBase FBgn0023174
Synonyms:beta2_dm EMBL AAB82570.1, Pros-beta-2 FlyBase FBgn0023174
ORF Names:CG3329 FlyBase FBgn0023174
OrganismDrosophila melanogaster (Fruit fly)
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length272 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity By similarity. RuleBase RU000694

Catalytic activity

Cleavage of peptide bonds with very broad specificity. RuleBase RU000694

Subunit structure

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits By similarity. RuleBase RU004203

Subcellular location

Cytoplasm. Nucleus By similarity RuleBase RU000694.

Sequence similarities

Belongs to the peptidase T1B family. RuleBase RU004202

Sequences

Sequence LengthMass (Da)Tools
O17311 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 2BFF408CB2DC91F2

FASTA27229,895
        10         20         30         40         50         60 
MDLDNARELP RAGFNFDNCK RNATLLNRGF KPPITTKTGT TIVGIIYKDG VILGADTRAT 

        70         80         90        100        110        120 
EGPIVSDKNC AKIHYLAKNI YCCGAGTAAD TEMTTDLISS QLELHRLQTD REVRVVAANT 

       130        140        150        160        170        180 
MLKQMLFRYQ GHISAALVLG GVDKTGPHIY SIHPHGSSDK LPYATMGSGS LAAMTVFESR 

       190        200        210        220        230        240 
WKPDLSEEEG KKLVRDADPT GVFNDLGSGS NIDLCVIRKG SVEYLRNYEL ANKKGKRQLD 

       250        260        270 
YRFKTGTSTV LHTNIKDLLV TERVQAVPME IS

« Hide

References

[1]"The dominant temperature-sensitive lethal DTS7 of Drosophila melanogaster encodes an altered 20S proteasome beta-type subunit."
Smyth K.A., Belote J.M.
Genetics 151:211-220(1999) [PubMed: 9872961] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF025791 mRNA. Translation: AAB82570.1.

3D structure databases

HSSPHSSP built from PDB template 1RYP based on UniProtKB P25043.
ProteinModelPortalO17311.
SMRO17311. Positions 40-258.
ModBaseSearch...

Protein-protein interaction databases

IntActO17311. 3 interactions.
STRINGO17311.

Protein family/group databases

MEROPST01.A02.

Proteomic databases

PRIDEO17311.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

FlyBaseFBgn0023174. Prosbeta2.

Phylogenomic databases

eggNOGinNOG09073.
InParanoidO17311.
OrthoDBEOG46HDSK.

Gene expression databases

ArrayExpressO17311.
BgeeO17311.

Family and domain databases

InterProIPR000243. Pept_T1A_subB.
IPR024689. Proteasome_bsu_C.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamPF12465. Pr_beta_C. 1 hit.
PF00227. Proteasome. 1 hit.
[Graphical view]
PRINTSPR00141. PROTEASOME.
PROSITEPS00854. PROTEASOME_B_1. 1 hit.
PS51476. PROTEASOME_B_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameO17311_DROME
AccessionPrimary (citable) accession number: O17311
Entry history
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: November 16, 2011
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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