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Protein

Sex-lethal homolog

Gene

SXL

Organism
Musca domestica (House fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Unknown; apparently not involved in somatic sex determination.

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sex-lethal homolog
Gene namesi
Name:SXL
OrganismiMusca domestica (House fly)
Taxonomic identifieri7370 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaMuscoideaMuscidaeMusca

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 324324Sex-lethal homologPRO_0000081970Add
BLAST

Expressioni

Tissue specificityi

Expressed in somatic cells of both sexes throughout development, but not in the pole cells which are the progenitors of the germline.

Developmental stagei

First appears in blastoderm embryos after onset of cellularisation.

Structurei

3D structure databases

ProteinModelPortaliO17310.
SMRiO17310. Positions 100-266.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini102 – 18079RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini188 – 26881RRM 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi88 – 947Poly-Gly

Sequence similaritiesi

Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

KOiK18747.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR002343. Hud_Sxl_RNA.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR006546. Sxl.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
PRINTSiPR00961. HUDSXLRNA.
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
TIGRFAMsiTIGR01659. sex-lethal. 1 hit.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform SXLC2 (identifier: O17310-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYGQNVRNVS YYPPYGYNGY KQSGERMWRM SHSLPSGMDT DFTSSYPGPS
60 70 80 90 100
AMNPRGRGGY NDFSGGGSAM GSMCNMAPAQ STNSLNSGGD GGGGDTQAVN
110 120 130 140 150
GTNLIVNYLP QDMTDRELYA LFRTCGPINT CRIMKDYKTG YSFGYAFVDF
160 170 180 190 200
ASEIDAQNAI KTVNGITVRN KRLKVSYARP GGESIKDTNL YVTNLPRTIT
210 220 230 240 250
DDELEKIFGK YGNIVQKNIL RDKLTGRPRG VAFVRFNKRE EAQEAISALN
260 270 280 290 300
NVIPEGASQP LTVRLAEEHG KMKAHHFMNQ LGMGPPAAPI PAAGPGYNNM
310 320
VHRGRQNKMR NHKVHPYHNP QKFI
Length:324
Mass (Da):35,755
Last modified:January 1, 1998 - v1
Checksum:iA665216EEA5CF767
GO
Isoform SXLC1 (identifier: O17310-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     304-324: GRQNKMRNHKVHPYHNPQKFI → AYNYSGLLDGFYRNKSYHYPYL

Show »
Length:325
Mass (Da):35,830
Checksum:i0EBAF0B9768788B6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 92NV → GT in AAB81985 (PubMed:9502729).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei304 – 32421GRQNK…PQKFI → AYNYSGLLDGFYRNKSYHYP YL in isoform SXLC1. 1 PublicationVSP_005891Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025689 mRNA. Translation: AAB81985.1.
AF025690 mRNA. Translation: AAB81986.1.
RefSeqiNP_001274464.1. NM_001287535.1. [O17310-1]
XP_005177313.1. XM_005177256.2. [O17310-2]

Genome annotation databases

GeneIDi101898639.
KEGGimde:101898639.
VectorBaseiMDOA004484-RB; MDOA004484-PB; MDOA004484.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025689 mRNA. Translation: AAB81985.1.
AF025690 mRNA. Translation: AAB81986.1.
RefSeqiNP_001274464.1. NM_001287535.1. [O17310-1]
XP_005177313.1. XM_005177256.2. [O17310-2]

3D structure databases

ProteinModelPortaliO17310.
SMRiO17310. Positions 100-266.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi101898639.
KEGGimde:101898639.
VectorBaseiMDOA004484-RB; MDOA004484-PB; MDOA004484.

Organism-specific databases

CTDi3772180.

Phylogenomic databases

KOiK18747.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR002343. Hud_Sxl_RNA.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR006546. Sxl.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
PRINTSiPR00961. HUDSXLRNA.
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
TIGRFAMsiTIGR01659. sex-lethal. 1 hit.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSXL_MUSDO
AccessioniPrimary (citable) accession number: O17310
Secondary accession number(s): O17309
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.