Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Ligand-Gated ion Channel

Gene

lgc-34

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channelSAAS annotation

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Ligand-Gated ion ChannelImported
Gene namesi
Name:lgc-34Imported
ORF Names:CELE_T27A1.4Imported, T27A1.4Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiT27A1.4; CE14211; WBGene00020836; lgc-34.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei244 – 26320HelicalSequence analysisAdd
BLAST
Transmembranei270 – 28920HelicalSequence analysisAdd
BLAST
Transmembranei301 – 32222HelicalSequence analysisAdd
BLAST
Transmembranei368 – 38821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: WormBase
  • postsynapse Source: GOC
Complete GO annotation...

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 390372Sequence analysisPRO_5004157296Add
BLAST

Proteomic databases

EPDiO17274.
PaxDbiO17274.
PRIDEiO17274.

Interactioni

Protein-protein interaction databases

STRINGi6239.T27A1.4.

Structurei

3D structure databases

ProteinModelPortaliO17274.
SMRiO17274. Positions 30-386.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 195164Neur_chan_LBDInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3644. Eukaryota.
ENOG410XP43. LUCA.
HOGENOMiHOG000018205.
InParanoidiO17274.
OMAiIVYLWAN.
OrthoDBiEOG7PCJMN.
PhylomeDBiO17274.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.

Sequencei

Sequence statusi: Complete.

O17274-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNIFLFLVL LSIGVCSAQK AFHSRRLGTE GQIVGRILSE YDSSSRPPVR
60 70 80 90 100
DHADNSAILV ITNIFINRLI WHNNYAEVDL YLRQQWQDSR LKYDVDTREG
110 120 130 140 150
IDEIRLPGNR KIWEPDTYFT SGKELSRNEK NSKHIVVEPS GYIRSSERVL
160 170 180 190 200
LELPYAYGTM FPFTNSRQFT IKLGSYNYDI DDIVYLWANS PPLVNPIEVS
210 220 230 240 250
QDLLKGDLTF EEASAGDCVG NYTVGVYSCI DAHVYFSAST ISGLMSWFLP
260 270 280 290 300
SLFLLIGSWL HFWIHGSWSV PRTISAAVPF FILAAYYIFM REDSYTQAQG
310 320 330 340 350
AWLAFCLVLT FFSFVEYFLV ICCGGRRSIR YKTLGPQEDH PMGAAKETVE
360 370 380 390
VAYNEGCASF RDNNGIDVIS RVAFPIVTIV FLIIYFIFIV
Length:390
Mass (Da):44,522
Last modified:January 1, 1998 - v1
Checksum:i6D86BA2897D169E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA. Translation: CCD73627.1.
PIRiG88022.
RefSeqiNP_493752.1. NM_061351.6.
UniGeneiCel.14273.

Genome annotation databases

EnsemblMetazoaiT27A1.4; T27A1.4; WBGene00020836.
GeneIDi173443.
KEGGicel:CELE_T27A1.4.
UCSCiT27A1.4. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA. Translation: CCD73627.1.
PIRiG88022.
RefSeqiNP_493752.1. NM_061351.6.
UniGeneiCel.14273.

3D structure databases

ProteinModelPortaliO17274.
SMRiO17274. Positions 30-386.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.T27A1.4.

Proteomic databases

EPDiO17274.
PaxDbiO17274.
PRIDEiO17274.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT27A1.4; T27A1.4; WBGene00020836.
GeneIDi173443.
KEGGicel:CELE_T27A1.4.
UCSCiT27A1.4. c. elegans.

Organism-specific databases

CTDi173443.
WormBaseiT27A1.4; CE14211; WBGene00020836; lgc-34.

Phylogenomic databases

eggNOGiKOG3644. Eukaryota.
ENOG410XP43. LUCA.
HOGENOMiHOG000018205.
InParanoidiO17274.
OMAiIVYLWAN.
OrthoDBiEOG7PCJMN.
PhylomeDBiO17274.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiO17274_CAEEL
AccessioniPrimary (citable) accession number: O17274
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: June 8, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.