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O17214

- FUMH_CAEEL

UniProt

O17214 - FUMH_CAEEL

Protein

Probable fumarate hydratase, mitochondrial

Gene

fum-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-malate = fumarate + H2O.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei138 – 1381SubstrateBy similarity

    GO - Molecular functioni

    1. fumarate hydratase activity Source: UniProtKB-EC

    GO - Biological processi

    1. fumarate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Enzyme and pathway databases

    UniPathwayiUPA00223; UER01007.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable fumarate hydratase, mitochondrial (EC:4.2.1.2)
    Short name:
    Fumarase
    Gene namesi
    Name:fum-1
    ORF Names:H14A12.2
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiH14A12.2a; CE11580; WBGene00001503; fum-1.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: WormBase
    2. tricarboxylic acid cycle enzyme complex Source: InterPro

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 501Probable fumarate hydratase, mitochondrialPRO_0000010328
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Proteomic databases

    PaxDbiO17214.
    PRIDEiO17214.

    2D gel databases

    World-2DPAGE0020:O17214.

    Interactioni

    Protein-protein interaction databases

    BioGridi41267. 6 interactions.
    DIPiDIP-25418N.
    IntActiO17214. 3 interactions.
    MINTiMINT-1047829.
    STRINGi6239.H14A12.2a.

    Structurei

    3D structure databases

    ProteinModelPortaliO17214.
    SMRiO17214. Positions 42-501.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni167 – 1704B siteBy similarity
    Regioni177 – 1793Substrate bindingBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0114.
    GeneTreeiENSGT00390000002779.
    HOGENOMiHOG000061736.
    InParanoidiO17214.
    KOiK01679.
    OMAiMFSGPMT.
    OrthoDBiEOG75J0MX.
    PhylomeDBiO17214.

    Family and domain databases

    Gene3Di1.10.275.10. 1 hit.
    HAMAPiMF_00743. FumaraseC.
    InterProiIPR005677. Fum_hydII.
    IPR024083. Fumarase/histidase_N.
    IPR018951. Fumarase_C_C.
    IPR020557. Fumarate_lyase_CS.
    IPR000362. Fumarate_lyase_fam.
    IPR022761. Fumarate_lyase_N.
    IPR008948. L-Aspartase-like.
    [Graphical view]
    PANTHERiPTHR11444. PTHR11444. 1 hit.
    PfamiPF10415. FumaraseC_C. 1 hit.
    PF00206. Lyase_1. 1 hit.
    [Graphical view]
    PRINTSiPR00149. FUMRATELYASE.
    SUPFAMiSSF48557. SSF48557. 1 hit.
    TIGRFAMsiTIGR00979. fumC_II. 1 hit.
    PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O17214-1 [UniParc]FASTAAdd to Basket

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    MSAVSMLQGE MLARGGAVIA RGASLATARN FSRTTVPMAK IRKERDTFGE    50
    LEVPADKYYG AQTARSQMNF KIGGPEERMP IPVIHAFGIL KKAAALVNTE 100
    FGLDKKLADA ISQAADEVVD GKLDEHFPLV TWQTGSGTQS NMNVNEVISN 150
    RAIEILGGEL GSKKPVHPND HVNMSQSSND TFPTAMHIAV GREVNSRLLP 200
    ALKKLRTALH NKAEEFKDII KIGRTHTQDA VPLTLGQEFS AYVTQLDNSI 250
    ARVESTLPRL YQLAAGGTAV GTGLNTRKGF AEKVAATVSE LTGLPFVTAP 300
    NKFEALAAHD ALVEVHGALN TVAVSFMKIG NDIRFLGSGP RCGLGELSLP 350
    ENEPGSSIMP GKVNPTQCEA ITMVAAQVMG NQVAVSVGGS NGHFELNVFK 400
    PLIVRNVLQS TRLLADSAVS FTDHCVDGIV ANKDNIAKIM RESLMLVTAL 450
    NPHIGYDNAA KIAKTAHKNG TTLVQEAVKL GILTEEQFAQ WVKPENMLGP 500
    K 501
    Length:501
    Mass (Da):53,647
    Last modified:January 1, 1998 - v1
    Checksum:iDA578BE105509C1D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO081548 Genomic DNA. Translation: CCD72341.1.
    PIRiC88508.
    RefSeqiNP_498642.1. NM_066241.7.
    UniGeneiCel.17823.

    Genome annotation databases

    EnsemblMetazoaiH14A12.2a; H14A12.2a; WBGene00001503.
    GeneIDi176059.
    KEGGicel:CELE_H14A12.2.
    UCSCiH14A12.2a. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO081548 Genomic DNA. Translation: CCD72341.1 .
    PIRi C88508.
    RefSeqi NP_498642.1. NM_066241.7.
    UniGenei Cel.17823.

    3D structure databases

    ProteinModelPortali O17214.
    SMRi O17214. Positions 42-501.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 41267. 6 interactions.
    DIPi DIP-25418N.
    IntActi O17214. 3 interactions.
    MINTi MINT-1047829.
    STRINGi 6239.H14A12.2a.

    2D gel databases

    World-2DPAGE 0020:O17214.

    Proteomic databases

    PaxDbi O17214.
    PRIDEi O17214.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai H14A12.2a ; H14A12.2a ; WBGene00001503 .
    GeneIDi 176059.
    KEGGi cel:CELE_H14A12.2.
    UCSCi H14A12.2a. c. elegans.

    Organism-specific databases

    CTDi 176059.
    WormBasei H14A12.2a ; CE11580 ; WBGene00001503 ; fum-1.

    Phylogenomic databases

    eggNOGi COG0114.
    GeneTreei ENSGT00390000002779.
    HOGENOMi HOG000061736.
    InParanoidi O17214.
    KOi K01679.
    OMAi MFSGPMT.
    OrthoDBi EOG75J0MX.
    PhylomeDBi O17214.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER01007 .

    Miscellaneous databases

    NextBioi 890934.
    PROi O17214.

    Family and domain databases

    Gene3Di 1.10.275.10. 1 hit.
    HAMAPi MF_00743. FumaraseC.
    InterProi IPR005677. Fum_hydII.
    IPR024083. Fumarase/histidase_N.
    IPR018951. Fumarase_C_C.
    IPR020557. Fumarate_lyase_CS.
    IPR000362. Fumarate_lyase_fam.
    IPR022761. Fumarate_lyase_N.
    IPR008948. L-Aspartase-like.
    [Graphical view ]
    PANTHERi PTHR11444. PTHR11444. 1 hit.
    Pfami PF10415. FumaraseC_C. 1 hit.
    PF00206. Lyase_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00149. FUMRATELYASE.
    SUPFAMi SSF48557. SSF48557. 1 hit.
    TIGRFAMsi TIGR00979. fumC_II. 1 hit.
    PROSITEi PS00163. FUMARATE_LYASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiFUMH_CAEEL
    AccessioniPrimary (citable) accession number: O17214
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 2003
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Miscellaneous

    There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors By similarity.By similarity

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3