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O17214

- FUMH_CAEEL

UniProt

O17214 - FUMH_CAEEL

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Protein

Probable fumarate hydratase, mitochondrial

Gene
fum-1, H14A12.2
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

(S)-malate = fumarate + H2O.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei138 – 1381Substrate By similarity

GO - Molecular functioni

  1. fumarate hydratase activity Source: UniProtKB-EC

GO - Biological processi

  1. fumarate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00223; UER01007.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable fumarate hydratase, mitochondrial (EC:4.2.1.2)
Short name:
Fumarase
Gene namesi
Name:fum-1
ORF Names:H14A12.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiH14A12.2a; CE11580; WBGene00001503; fum-1.

Subcellular locationi

Mitochondrion By similarity UniRule annotation

GO - Cellular componenti

  1. mitochondrion Source: WormBase
  2. tricarboxylic acid cycle enzyme complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 501Probable fumarate hydratase, mitochondrialUniRule annotationPRO_0000010328
Transit peptidei1 – ?Mitochondrion Reviewed prediction

Proteomic databases

PaxDbiO17214.
PRIDEiO17214.

2D gel databases

World-2DPAGE0020:O17214.

Interactioni

Protein-protein interaction databases

BioGridi41267. 6 interactions.
DIPiDIP-25418N.
IntActiO17214. 3 interactions.
MINTiMINT-1047829.
STRINGi6239.H14A12.2a.

Structurei

3D structure databases

ProteinModelPortaliO17214.
SMRiO17214. Positions 42-501.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni167 – 1704B site By similarity
Regioni177 – 1793Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0114.
GeneTreeiENSGT00390000002779.
HOGENOMiHOG000061736.
InParanoidiO17214.
KOiK01679.
OMAiMFSGPMT.
OrthoDBiEOG75J0MX.
PhylomeDBiO17214.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
HAMAPiMF_00743. FumaraseC.
InterProiIPR005677. Fum_hydII.
IPR024083. Fumarase/histidase_N.
IPR018951. Fumarase_C_C.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PfamiPF10415. FumaraseC_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00979. fumC_II. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O17214-1 [UniParc]FASTAAdd to Basket

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MSAVSMLQGE MLARGGAVIA RGASLATARN FSRTTVPMAK IRKERDTFGE    50
LEVPADKYYG AQTARSQMNF KIGGPEERMP IPVIHAFGIL KKAAALVNTE 100
FGLDKKLADA ISQAADEVVD GKLDEHFPLV TWQTGSGTQS NMNVNEVISN 150
RAIEILGGEL GSKKPVHPND HVNMSQSSND TFPTAMHIAV GREVNSRLLP 200
ALKKLRTALH NKAEEFKDII KIGRTHTQDA VPLTLGQEFS AYVTQLDNSI 250
ARVESTLPRL YQLAAGGTAV GTGLNTRKGF AEKVAATVSE LTGLPFVTAP 300
NKFEALAAHD ALVEVHGALN TVAVSFMKIG NDIRFLGSGP RCGLGELSLP 350
ENEPGSSIMP GKVNPTQCEA ITMVAAQVMG NQVAVSVGGS NGHFELNVFK 400
PLIVRNVLQS TRLLADSAVS FTDHCVDGIV ANKDNIAKIM RESLMLVTAL 450
NPHIGYDNAA KIAKTAHKNG TTLVQEAVKL GILTEEQFAQ WVKPENMLGP 500
K 501
Length:501
Mass (Da):53,647
Last modified:January 1, 1998 - v1
Checksum:iDA578BE105509C1D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO081548 Genomic DNA. Translation: CCD72341.1.
PIRiC88508.
RefSeqiNP_498642.1. NM_066241.7.
UniGeneiCel.17823.

Genome annotation databases

EnsemblMetazoaiH14A12.2a; H14A12.2a; WBGene00001503.
GeneIDi176059.
KEGGicel:CELE_H14A12.2.
UCSCiH14A12.2a. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO081548 Genomic DNA. Translation: CCD72341.1 .
PIRi C88508.
RefSeqi NP_498642.1. NM_066241.7.
UniGenei Cel.17823.

3D structure databases

ProteinModelPortali O17214.
SMRi O17214. Positions 42-501.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 41267. 6 interactions.
DIPi DIP-25418N.
IntActi O17214. 3 interactions.
MINTi MINT-1047829.
STRINGi 6239.H14A12.2a.

2D gel databases

World-2DPAGE 0020:O17214.

Proteomic databases

PaxDbi O17214.
PRIDEi O17214.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai H14A12.2a ; H14A12.2a ; WBGene00001503 .
GeneIDi 176059.
KEGGi cel:CELE_H14A12.2.
UCSCi H14A12.2a. c. elegans.

Organism-specific databases

CTDi 176059.
WormBasei H14A12.2a ; CE11580 ; WBGene00001503 ; fum-1.

Phylogenomic databases

eggNOGi COG0114.
GeneTreei ENSGT00390000002779.
HOGENOMi HOG000061736.
InParanoidi O17214.
KOi K01679.
OMAi MFSGPMT.
OrthoDBi EOG75J0MX.
PhylomeDBi O17214.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER01007 .

Miscellaneous databases

NextBioi 890934.
PROi O17214.

Family and domain databases

Gene3Di 1.10.275.10. 1 hit.
HAMAPi MF_00743. FumaraseC.
InterProi IPR005677. Fum_hydII.
IPR024083. Fumarase/histidase_N.
IPR018951. Fumarase_C_C.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view ]
PANTHERi PTHR11444. PTHR11444. 1 hit.
Pfami PF10415. FumaraseC_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view ]
PRINTSi PR00149. FUMRATELYASE.
SUPFAMi SSF48557. SSF48557. 1 hit.
TIGRFAMsi TIGR00979. fumC_II. 1 hit.
PROSITEi PS00163. FUMARATE_LYASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiFUMH_CAEEL
AccessioniPrimary (citable) accession number: O17214
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: January 1, 1998
Last modified: June 11, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Miscellaneous

There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors By similarity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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