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Protein

T-box transcription factor mls-1

Gene

mls-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable transcription factor required for the cell fate specification of non-striated uterine muscle precursor cells (PubMed:11799068, PubMed:21852953). Furthermore, may function with the transcriptional corepressor unc-37 (PubMed:21852953).2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi40 – 210T-boxPROSITE-ProRule annotationAdd BLAST171

GO - Molecular functioni

GO - Biological processi

  • muscle cell fate specification Source: WormBase
  • post-embryonic development Source: WormBase
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
T-box transcription factor mls-12 Publications
Alternative name(s):
Mesodermal lineage specification protein 1Imported
Gene namesi
Name:mls-1Imported
ORF Names:H14A12.4Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiH14A12.4 ; CE11584 ; WBGene00003376 ; mls-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Non-striated muscle cell fate specification defects whereby the number of vulval cells is doubled and the number of uterine cells is reduced due to the transformation of uterine cells into vulval cells.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi5 – 7FSI → ASA: Abolishes unc-37 binding. 1 Publication3
Mutagenesisi68I → N in cc571; increased number of vulval cells. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004381751 – 252T-box transcription factor mls-1CuratedAdd BLAST252

Proteomic databases

PaxDbiO17212
PRIDEiO17212

Expressioni

Developmental stagei

During the larval stage of development, expressed in uterine muscle progenitors and their descendants in the sex myoblast lineage, but only expressed in type 2 vulval muscle precursor cells of the vulval muscle lineage (PubMed:11799068). In larvae, it is also expressed in a subset of enteric muscle cells including the left and right intestinal muscles and the anal depressor muscle (PubMed:11799068, PubMed:21852953).2 Publications

Gene expression databases

BgeeiWBGene00003376

Interactioni

Subunit structurei

May interact with unc-37.1 Publication

Protein-protein interaction databases

STRINGi6239.H14A12.4

Structurei

3D structure databases

ProteinModelPortaliO17212
SMRiO17212
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG3586 Eukaryota
ENOG410Y98J LUCA
GeneTreeiENSGT00760000118897
HOGENOMiHOG000286000
InParanoidiO17212
OMAiISHEESP
OrthoDBiEOG091G0I8R
PhylomeDBiO17212

Family and domain databases

CDDicd00182 TBOX, 1 hit
Gene3Di2.60.40.820, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR036960 T-box_sf
IPR001699 TF_T-box
IPR018186 TF_T-box_CS
PANTHERiPTHR11267 PTHR11267, 1 hit
PfamiView protein in Pfam
PF00907 T-box, 1 hit
PRINTSiPR00937 TBOX
SMARTiView protein in SMART
SM00425 TBOX, 1 hit
SUPFAMiSSF49417 SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS01283 TBOX_1, 1 hit
PS50252 TBOX_3, 1 hit

Sequencei

Sequence statusi: Complete.

O17212-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRNFSIDAI LARKPVEKRK QIITKDNCKF IRVFLQSSNL WRRFHNLGTE
60 70 80 90 100
MIVTKSGRRM FPTLSVIIAG LDPVKSYVVM VDLECIEMKR FRYSFHQSKW
110 120 130 140 150
ISTGPGESEL PSRMFVHTDS PARGAHWMRA PVSFDKMKLT NNQLDNNGHI
160 170 180 190 200
IVNSMHKYRP RVHIIEQDDS QKRHTFSFEE TEFIAVTAYQ NHRITSLKIE
210 220 230 240 250
SNPFAKGFRE CEVQGIEMNS VGGMTGGPAF QSVFPLIFPY FANLASNMNV

NK
Length:252
Mass (Da):29,067
Last modified:January 1, 1998 - v1
Checksum:i0DFDB0A9F4F9B130
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA Translation: CCD72344.1
PIRiA88508
RefSeqiNP_498640.1, NM_066239.3
UniGeneiCel.10354

Genome annotation databases

EnsemblMetazoaiH14A12.4; H14A12.4; WBGene00003376
GeneIDi186741
KEGGicel:CELE_H14A12.4
UCSCiH14A12.4 c. elegans

Similar proteinsi

Entry informationi

Entry nameiTBX1_CAEEL
AccessioniPrimary (citable) accession number: O17212
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2016
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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