Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

T-box transcription factor mls-1

Gene

mls-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable transcription factor required for the cell fate specification of non-striated uterine muscle precursor cells (PubMed:11799068, PubMed:21852953). Furthermore, may function with the transcriptional corepressor unc-37 (PubMed:21852953).2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi40 – 210T-boxPROSITE-ProRule annotationAdd BLAST171

GO - Molecular functioni

GO - Biological processi

  • muscle cell fate specification Source: WormBase
  • post-embryonic development Source: WormBase
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
T-box transcription factor mls-12 Publications
Alternative name(s):
Mesodermal lineage specification protein 1Imported
Gene namesi
Name:mls-1Imported
ORF Names:H14A12.4Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiH14A12.4; CE11584; WBGene00003376; mls-1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • nucleus Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Non-striated muscle cell fate specification defects whereby the number of vulval cells is doubled and the number of uterine cells is reduced due to the transformation of uterine cells into vulval cells.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi5 – 7FSI → ASA: Abolishes unc-37 binding. 1 Publication3
Mutagenesisi68I → N in cc571; increased number of vulval cells. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004381751 – 252T-box transcription factor mls-1CuratedAdd BLAST252

Proteomic databases

PaxDbiO17212.

Expressioni

Developmental stagei

During the larval stage of development, expressed in uterine muscle progenitors and their descendants in the sex myoblast lineage, but only expressed in type 2 vulval muscle precursor cells of the vulval muscle lineage (PubMed:11799068). In larvae, it is also expressed in a subset of enteric muscle cells including the left and right intestinal muscles and the anal depressor muscle (PubMed:11799068, PubMed:21852953).2 Publications

Gene expression databases

BgeeiWBGene00003376.

Interactioni

Subunit structurei

May interact with unc-37.1 Publication

Protein-protein interaction databases

STRINGi6239.H14A12.4.

Structurei

3D structure databases

ProteinModelPortaliO17212.
SMRiO17212.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 T-box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3586. Eukaryota.
ENOG410Y98J. LUCA.
GeneTreeiENSGT00760000118897.
HOGENOMiHOG000286000.
InParanoidiO17212.
OMAiRQVISFQ.
OrthoDBiEOG091G0I8R.
PhylomeDBiO17212.

Family and domain databases

CDDicd00182. TBOX. 1 hit.
Gene3Di2.60.40.820. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view]
PANTHERiPTHR11267. PTHR11267. 1 hit.
PfamiPF00907. T-box. 1 hit.
[Graphical view]
PRINTSiPR00937. TBOX.
SMARTiSM00425. TBOX. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
PROSITEiPS01283. TBOX_1. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O17212-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRNFSIDAI LARKPVEKRK QIITKDNCKF IRVFLQSSNL WRRFHNLGTE
60 70 80 90 100
MIVTKSGRRM FPTLSVIIAG LDPVKSYVVM VDLECIEMKR FRYSFHQSKW
110 120 130 140 150
ISTGPGESEL PSRMFVHTDS PARGAHWMRA PVSFDKMKLT NNQLDNNGHI
160 170 180 190 200
IVNSMHKYRP RVHIIEQDDS QKRHTFSFEE TEFIAVTAYQ NHRITSLKIE
210 220 230 240 250
SNPFAKGFRE CEVQGIEMNS VGGMTGGPAF QSVFPLIFPY FANLASNMNV

NK
Length:252
Mass (Da):29,067
Last modified:January 1, 1998 - v1
Checksum:i0DFDB0A9F4F9B130
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA. Translation: CCD72344.1.
PIRiA88508.
RefSeqiNP_498640.1. NM_066239.3.
UniGeneiCel.10354.

Genome annotation databases

EnsemblMetazoaiH14A12.4; H14A12.4; WBGene00003376.
GeneIDi186741.
KEGGicel:CELE_H14A12.4.
UCSCiH14A12.4. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA. Translation: CCD72344.1.
PIRiA88508.
RefSeqiNP_498640.1. NM_066239.3.
UniGeneiCel.10354.

3D structure databases

ProteinModelPortaliO17212.
SMRiO17212.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.H14A12.4.

Proteomic databases

PaxDbiO17212.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiH14A12.4; H14A12.4; WBGene00003376.
GeneIDi186741.
KEGGicel:CELE_H14A12.4.
UCSCiH14A12.4. c. elegans.

Organism-specific databases

CTDi186741.
WormBaseiH14A12.4; CE11584; WBGene00003376; mls-1.

Phylogenomic databases

eggNOGiKOG3586. Eukaryota.
ENOG410Y98J. LUCA.
GeneTreeiENSGT00760000118897.
HOGENOMiHOG000286000.
InParanoidiO17212.
OMAiRQVISFQ.
OrthoDBiEOG091G0I8R.
PhylomeDBiO17212.

Gene expression databases

BgeeiWBGene00003376.

Family and domain databases

CDDicd00182. TBOX. 1 hit.
Gene3Di2.60.40.820. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view]
PANTHERiPTHR11267. PTHR11267. 1 hit.
PfamiPF00907. T-box. 1 hit.
[Graphical view]
PRINTSiPR00937. TBOX.
SMARTiSM00425. TBOX. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
PROSITEiPS01283. TBOX_1. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTBX1_CAEEL
AccessioniPrimary (citable) accession number: O17212
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2016
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.