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Protein

Probable 26S protease regulatory subunit 10B

Gene

rpt-4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi191 – 198ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-CEL-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-CEL-382556. ABC-family proteins mediated transport.
R-CEL-4641258. Degradation of DVL.
R-CEL-5632684. Hedgehog 'on' state.
R-CEL-5689603. UCH proteinases.
R-CEL-5689880. Ub-specific processing proteases.
R-CEL-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-CEL-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-CEL-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-CEL-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 26S protease regulatory subunit 10B
Alternative name(s):
26S proteasome AAA-ATPase subunit rpt-4
Proteasome regulatory particle ATPase-like protein 4
Gene namesi
Name:rpt-4
ORF Names:F23F1.8
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiF23F1.8a; CE29280; WBGene00004504; rpt-4.
F23F1.8b; CE09608; WBGene00004504; rpt-4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000847351 – 406Probable 26S protease regulatory subunit 10BAdd BLAST406

Proteomic databases

EPDiO17071.
PaxDbiO17071.
PeptideAtlasiO17071.
PRIDEiO17071.

PTM databases

iPTMnetiO17071.

Expressioni

Gene expression databases

BgeeiWBGene00004504.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-320304,EBI-320304
rpt-5O7637110EBI-320304,EBI-317201

GO - Molecular functioni

Protein-protein interaction databases

BioGridi38764. 8 interactors.
IntActiO17071. 9 interactors.
MINTiMINT-210603.
STRINGi6239.F23F1.8a.

Structurei

3D structure databases

ProteinModelPortaliO17071.
SMRiO17071.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Phylogenomic databases

eggNOGiKOG0651. Eukaryota.
COG1222. LUCA.
GeneTreeiENSGT00550000074826.
HOGENOMiHOG000225143.
InParanoidiO17071.
KOiK03064.
OMAiFSDYRKK.
OrthoDBiEOG091G096W.
PhylomeDBiO17071.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR005937. 26S_Psome_P45.
IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01242. 26Sp45. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: O17071-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLLQFSNMV EPTGPAIVED ERTKALNSYR RKLAECRDIE QKLKDLRKKE
60 70 80 90 100
SEMTKQFDKS ENDIKSLQSV GQIVGEVLKQ LSEEKFIVKA TNGPRYVVGC
110 120 130 140 150
RRSINKEELK QGTRVSLDMT TLTIMRQLPR EVDPLVYKMS HEDPGNISYS
160 170 180 190 200
DVGGLAEQIR ELREVVELPL INPELFKRVG ITPPKGCLLF GPPGTGKTLL
210 220 230 240 250
ARAVASQLDC NFLKVVSSAI VDKYIGESAR MIREMFNYAR DHQPCIVFMD
260 270 280 290 300
EIDAIGGRRF SEGTSADREI QRTLMELLNQ LDGFDSLGKV KVIMATNRPD
310 320 330 340 350
TLDPALLRPG RLDRKIEIGL PNEQSRLEIL KIHSNKITKH GEIDFEAVVK
360 370 380 390 400
LSDGFSAADL RNVCTEAGMF AIRAEREFVI DEDFMKAVRK VGDAKRLETK

LDYKPV
Note: No experimental confirmation available.
Length:406
Mass (Da):45,859
Last modified:May 27, 2002 - v2
Checksum:iDCD706704840F529
GO
Isoform b (identifier: O17071-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: Missing.

Note: No experimental confirmation available.
Show »
Length:398
Mass (Da):44,912
Checksum:i77204F8C9668F324
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0155581 – 8Missing in isoform b. Curated8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080251 Genomic DNA. Translation: CCD62357.1.
FO080251 Genomic DNA. Translation: CCD62358.1.
PIRiT32268.
RefSeqiNP_001022113.1. NM_001026942.3. [O17071-1]
NP_001022114.1. NM_001026943.3. [O17071-2]
UniGeneiCel.7235.

Genome annotation databases

EnsemblMetazoaiF23F1.8a; F23F1.8a; WBGene00004504. [O17071-1]
GeneIDi173384.
KEGGicel:CELE_F23F1.8.
UCSCiF23F1.8a. c. elegans. [O17071-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080251 Genomic DNA. Translation: CCD62357.1.
FO080251 Genomic DNA. Translation: CCD62358.1.
PIRiT32268.
RefSeqiNP_001022113.1. NM_001026942.3. [O17071-1]
NP_001022114.1. NM_001026943.3. [O17071-2]
UniGeneiCel.7235.

3D structure databases

ProteinModelPortaliO17071.
SMRiO17071.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi38764. 8 interactors.
IntActiO17071. 9 interactors.
MINTiMINT-210603.
STRINGi6239.F23F1.8a.

PTM databases

iPTMnetiO17071.

Proteomic databases

EPDiO17071.
PaxDbiO17071.
PeptideAtlasiO17071.
PRIDEiO17071.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF23F1.8a; F23F1.8a; WBGene00004504. [O17071-1]
GeneIDi173384.
KEGGicel:CELE_F23F1.8.
UCSCiF23F1.8a. c. elegans. [O17071-1]

Organism-specific databases

CTDi173384.
WormBaseiF23F1.8a; CE29280; WBGene00004504; rpt-4.
F23F1.8b; CE09608; WBGene00004504; rpt-4.

Phylogenomic databases

eggNOGiKOG0651. Eukaryota.
COG1222. LUCA.
GeneTreeiENSGT00550000074826.
HOGENOMiHOG000225143.
InParanoidiO17071.
KOiK03064.
OMAiFSDYRKK.
OrthoDBiEOG091G096W.
PhylomeDBiO17071.

Enzyme and pathway databases

ReactomeiR-CEL-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-CEL-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-CEL-382556. ABC-family proteins mediated transport.
R-CEL-4641258. Degradation of DVL.
R-CEL-5632684. Hedgehog 'on' state.
R-CEL-5689603. UCH proteinases.
R-CEL-5689880. Ub-specific processing proteases.
R-CEL-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-CEL-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-CEL-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-CEL-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

PROiO17071.

Gene expression databases

BgeeiWBGene00004504.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR005937. 26S_Psome_P45.
IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01242. 26Sp45. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRS10_CAEEL
AccessioniPrimary (citable) accession number: O17071
Secondary accession number(s): Q5F4U7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 27, 2002
Last modified: November 30, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.