O16925 (STDH4_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative steroid dehydrogenase 4
EC=1.1.1.-

Gene names

Name:	stdh-4
Synonyms:	tag-57
ORF Names:	F25G6.5

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	263 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.

Ontologies

Keywords
Biological process	Lipid biosynthesis Lipid metabolism Steroid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	steroid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	nucleotide binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 263	263	Putative steroid dehydrogenase 4		PRO_0000054582
Sites
	Active site	154	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	O16925 [UniParc]. Last modified October 3, 2012. Version 2. Checksum: 4175D4AA01E80D50	FASTA	263	29,521
	10 20 30 40 50 60 MKVVTGATDG IGRSYALDLA RRGFNIFLIS RTKSKLVKTK KQILNKYSDI EVRYAICDFT 70 80 90 100 110 120 RVSYEDYKRL LHSLNEVDIG ILINNVGMCF DNPEVLHRVE GGIDTLTNVI NVNILPVTLL 130 140 150 160 170 180 TAGILPQMMA RKSGIIVNIG SAAGSIHMAK WSVYSATKKY IEWFTSILQK EYENEGIICQ 190 200 210 220 230 240 TITPLLVSTN MIKNPLSSIF CPNSDSFAKS SLNTIGNSSS TTGYITHQIQ FELIKFVPEI 250 260 IIDLFVKNLN NQLLDYQLDK KRV

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FO080489 Genomic DNA. Translation: CCD64105.2.
PIR	D89134.
RefSeq	NP_505205.2. NM_072804.2.
3D structure databases
ProteinModelPortal	O16925.
SMR	O16925. Positions 3-226.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	F25G6.5; F25G6.5; F25G6.5.
GeneID	184934.
KEGG	cel:CELE_F25G6.5.
Organism-specific databases
CTD	184934.
WormBase	F25G6.5; CE09641; WBGene00006435; stdh-4.
Phylogenomic databases
eggNOG	COG0300.
GeneTree	ENSGT00390000010069.
HOGENOM	HOG000039237.
InParanoid	O16925.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
InterPro	IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. IPR020904. Sc_DH/Rdtase_CS. [Graphical view]
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PIRSF	PIRSF000126. 11-beta-HSD1. 1 hit.
PRINTS	PR00081. GDHRDH. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	926462.

Entry information

Entry name

STDH4_CAEEL

Accession

Primary (citable) accession number: O16925

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	October 3, 2012
Last modified:	May 1, 2013
This is version 75 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project