Reviewed, UniProtKB/Swiss-Prot O16867 (TAP_DROME)

Names and origin

Protein names

Recommended name:
    Basic helix-loop-helix neural transcription factor TAP
Alternative name(s):
    Target of Poxn protein
    Protein biparous

Gene names

Name:	tap
Synonyms:	bps
ORF Names:	CG7659

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	398 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May play a role in the specification of the sugar-sensitive adult gustatory neuron and affect the response to sugar and salt. Regulated by POXN. Ref.1 Ref.2 Ref.6
Subcellular location	Nucleus Potential.
Tissue specificity	Expressed in neuronal and glial precursors during differentiation. In the peripheral nervous system, expression is exclusively in one of the neurons that innervate each larval chemosensory organ. Expressed at a late stage in the development of one type of adult chemosensory organ, the gustatory bristles of the leg, wing and proboscis. Expressed very early in the development of a second type of chemosensory receptors, the olfactory organs of the antenna. Ref.1 Ref.2 Ref.6
Developmental stage	Expressed in embryos, expression continues to the final stages of neurogenesis. Ref.1
Sequence similarities	Contains 1 basic helix-loop-helix (bHLH) domain.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW nervous system development Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW sensory organ development Traceable author statement. Source: FlyBase transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: IntAct transcription regulator activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
HLHm5	P13096	1	EBI-102737,EBI-104760
HLHmbeta	Q01069	1	EBI-102737,EBI-94554

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 398	398	Basic helix-loop-helix neural transcription factor TAP		PRO_0000127459
Regions
	Domain	167 – 207	41	Helix-loop-helix motif
	DNA binding	155 – 166	12	Basic motif
	Compositional bias	18 – 23	6	Poly-Asp
	Compositional bias	308 – 334	27	Gln-rich

Sequences

	Sequence		Length	Mass (Da)
	O16867-1 [UniParc]. Last modified January 1, 1999. Version 2. Checksum: 54FF558483B18258	FASTA	398	44,851
	10 20 30 40 50 60 MAACYNAYSA GSQSFEFDED DDDASFDSGY EKSFETEAQL SSRRRLDFGT PPTPAIPQPY 70 80 90 100 110 120 SGGTWDAVPL SSPPAGFVGL LDTSSNHSTR SGRTLVEHLN SRATNGVFDP PLTSTPVKSP 130 140 150 160 170 180 EDPNAPRPKR KYAVGKNRVT RSRSPTQVVK IKRFRRMKAN DRERNRMHNL NDALEKLRVT 190 200 210 220 230 240 LPSLPEETKL TKIEILRFAH NYIFALEQVL ESGGSINLDL EKLQNFTLSG ERITKELFDA 250 260 270 280 290 300 LFVNPQPYPL FGRMFPYGQG MAPLAQHQTA PASHAEQPPA MGGFQHGMDY PQQPPGFDFT 310 320 330 340 350 360 GSMRFYHQQQ QQPHQPHHLQ PNPQQESSPQ QFSQEKYDLF RGSFDAAANL HSTNLDSGIH 370 380 390 QQSSFYSQTP PWKDYPEDQA HVHPVPHQHS YKNFAPQV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Biparous: a novel bHLH gene expressed in neuronal and glial precursors in Drosophila." Bush A.B., Hiromi Y.H., Cole M.D. Dev. Biol. 180:759-772(1996) [PubMed: 8954743] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[2]	"tap, a Drosophila bHLH gene expressed in chemosensory organs." Gautier P., Ledent V., Massaer M., Dambly-Chaudiere C., Ghysen A. Gene 191:15-21(1997) [PubMed: 9210583] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY. Strain: Oregon-R.
[3]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[4]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.
[5]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Embryo.
[6]	"Expression and function of tap in the gustatory and olfactory organs of Drosophila." Ledent V., Gaillard F., Gautier P., Ghysen A., Dambly-Chaudiere C. Int. J. Dev. Biol. 42:163-170(1998) [PubMed: 9551861] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY. Strain: Oregon-R.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF022883 mRNA. Translation: AAC80572.1. X95845 mRNA. Translation: CAA65103.1. AE014296 Genomic DNA. Translation: AAF49352.1. AY119146 mRNA. Translation: AAM51006.1.
RefSeq	NP_524124.1.
UniGene	Dm.5399
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:21817N.
IntAct	O16867. 6 interactions.
Genome annotation databases
Ensembl	FBgn0015550. Drosophila melanogaster. [Contig view]
GeneID	39935.
KEGG	dme:Dmel_CG7659.
NMPDR	fig|7227.3.peg.10300.
Organism-specific databases
FlyBase	FBgn0015550. tap.
Phylogenomic databases
HOGENOM	O16867.
OMA	O16867. CYNAYSA.
Enzyme and pathway databases
BioCyc	DMEL-XXX-02:DMEL-XXX-02-017105-MON.
Gene expression databases
ArrayExpress	O16867.
GermOnline	CG7659. Drosophila melanogaster.
Family and domain databases
InterPro	IPR001092. HLH_basic. IPR011598. HLH_DNA_bd. [Graphical view]
Gene3D	G3DSA:4.10.280.10. HLH_DNA_bd. 1 hit.
Pfam	PF00010. HLH. 1 hit. [Graphical view]
SMART	SM00353. HLH. 1 hit. [Graphical view]
PROSITE	PS50888. HLH. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	816159.

Entry information

Entry name

TAP_DROME

Accession

Primary (citable) accession number: O16867
Secondary accession number(s): P91640, Q9VVF9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 1, 1999
Last modified:	June 16, 2009
This is version 66 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project