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Protein
Submitted name:

Kinesin-like protein, KLP38B

Gene

neb

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ATP-dependent microtubule motor activity, plus-end-directed Source: FlyBase
  • chromatin binding Source: FlyBase
  • microtubule motor activity Source: FlyBase
  • protein phosphatase 1 binding Source: FlyBase

GO - Biological processi

  • chromosome segregation Source: FlyBase
  • meiotic nuclear division Source: FlyBase
  • microtubule-based movement Source: FlyBase
  • mitotic cell cycle, embryonic Source: FlyBase
  • mitotic chromosome condensation Source: FlyBase
  • mitotic sister chromatid segregation Source: FlyBase
  • oogenesis Source: FlyBase
  • ovarian follicle cell development Source: FlyBase
  • regulation of cell cycle Source: FlyBase
Complete GO annotation...

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-5625900. RHO GTPases activate CIT.
SignaLinkiO16866.

Names & Taxonomyi

Protein namesi
Submitted name:
Kinesin-like protein, KLP38BImported
Gene namesi
Name:nebImported
ORF Names:CG10718Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0004374. neb.

Subcellular locationi

GO - Cellular componenti

  • heterochromatin Source: FlyBase
  • kinesin complex Source: FlyBase
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiO16866.
PeptideAtlasiO16866.

Expressioni

Gene expression databases

BgeeiO16866.
ExpressionAtlasiO16866. differential.

Interactioni

GO - Molecular functioni

  • protein phosphatase 1 binding Source: FlyBase

Protein-protein interaction databases

STRINGi7227.FBpp0080864.

Structurei

3D structure databases

ProteinModelPortaliO16866.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini120 – 518399Kinesin motorInterPro annotationAdd
BLAST
Domaini658 – 71659FHAInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili533 – 55624Sequence analysisAdd
BLAST
Coiled coili579 – 62143Sequence analysisAdd
BLAST
Coiled coili760 – 79132Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.SAAS annotation
Contains kinesin motor domain.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0245. Eukaryota.
COG5059. LUCA.
OrthoDBiEOG74TWXS.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
3.40.850.10. 1 hit.
InterProiIPR000253. FHA_dom.
IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 3 hits.
PfamiPF00498. FHA. 1 hit.
PF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00240. FHA. 1 hit.
SM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
PS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O16866-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNKSTPVRQ RIQQFQTRGV HKSTPASEMR KKVLMTRAED REHRDRPEQL
60 70 80 90 100
LNTAFSGSTP QPKPKPTALN ACYTPSSLYR NANSTPGRAK TPGTGKSSCS
110 120 130 140 150
RTKERDSLME SCLSVSEESN MIVAVRVRPL NALECTRGQV TNVVQVHGNS
160 170 180 190 200
NELTVQAGSS ADASAGVTHF FSYDQVYYSC DPERKNFACQ AKVFEGTARP
210 220 230 240 250
LIDTAFEGYN ACLFAYGQTG SGKSYSMMGI EALDDAALDG GPPHDEAGII
260 270 280 290 300
PRFCHELFRR IEAVKSQQQL QVEVEVSYFE IYNEKIHDLL SVQHAAAATG
310 320 330 340 350
ESTPIQQQQQ QQRPALKVRE HPIFGPYVVD LSAHSVDSYS ALRNWLAVGN
360 370 380 390 400
SQRATASTAM NDKSSRSHSI FNIVLNLTDL SSDDGLSSDT DSSTASSLRQ
410 420 430 440 450
TRRSKISLVD LAGSERISVS GSNGERIREG VSINKSLLTL GKVIAALADS
460 470 480 490 500
RKASANGPLG SGTPSTFVPY RESVLTWLLR ENLGGNSKTV MLATISPASI
510 520 530 540 550
HADETLATLR YACKARSIVN RVKVNESPHD KIIRDLRAEV DRLKSLRNEY
560 570 580 590 600
ERQRRLSGNS NNPVPRKIII ETSVDETEVE ALRQQLAERE RELSRAQKSW
610 620 630 640 650
MEKLKEAEDQ RKSELRVLKR RGLALELTAE QKQACLVNLT ADPILSGTLF
660 670 680 690 700
YLLPQGLVRI GRGRLPGGSS SSQPDIVLDG PLVALQHCSI EHERGGKLYV
710 720 730 740 750
IPGSEDFETY VNGELLKDRR QLFHGDRLVI GGSHYFRISN PFCSQRGKAD
760 770 780 790 800
HPVDFQLAHQ EILQKQEQQL RSELEAEKRA ALTKIEQERA QHARDFEERL
810 820 830 840 850
QCLELEQFKY KCNSEMLETE RQALALAQQQ EHTPLRHEDA VSTPAQKSTI
860 870 880 890 900
LEDIQRIMLN PSEESLHKTQ LMVKEATQRC RQLDLPLEFR QTQTPDEFGL
910 920 930 940 950
LRTVILILDK QRGLKAEWPT ARLGVWLDLV RDNAEQQEKL NATTIFQSVE
960 970 980 990 1000
VDWEPLDADL NETLSDTHNS SRIALNLSAM KDVLLNKPLK RLLNASSSKS
1010 1020 1030 1040 1050
NTPRQTSTPS PGSQLVHFTK RLLTYDPEEI PESQSSFTTL VQQELQIMQR
1060 1070 1080 1090 1100
SAQRLRRHCE AALLERENHQ DNGVLAVSLQ EALARMDTVL NGMHTSLARA
1110 1120
EATACVTSPT KTQKAVRFLI D
Length:1,121
Mass (Da):125,195
Last modified:October 1, 2000 - v2
Checksum:i7ACD73627C8DA458
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10667 mRNA. Translation: CAA71675.1.
PIRiT13750.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10667 mRNA. Translation: CAA71675.1.
PIRiT13750.

3D structure databases

ProteinModelPortaliO16866.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0080864.

Proteomic databases

PaxDbiO16866.
PeptideAtlasiO16866.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0004374. neb.

Phylogenomic databases

eggNOGiKOG0245. Eukaryota.
COG5059. LUCA.
OrthoDBiEOG74TWXS.

Enzyme and pathway databases

ReactomeiR-DME-5625900. RHO GTPases activate CIT.
SignaLinkiO16866.

Miscellaneous databases

ChiTaRSineb. fly.

Gene expression databases

BgeeiO16866.
ExpressionAtlasiO16866. differential.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
3.40.850.10. 1 hit.
InterProiIPR000253. FHA_dom.
IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 3 hits.
PfamiPF00498. FHA. 1 hit.
PF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00240. FHA. 1 hit.
SM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
PS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Mutation of a gene for a Drosophila kinesin like protein, KLP38B, leads to failure of cytokinesis."
    Ohkura H., Torok T., Tick G., Hoheisel J., Kiss I., Glover D.M.
    J. Cell Sci. 110:945-954(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO16866_DROME
AccessioniPrimary (citable) accession number: O16866
Secondary accession number(s): O02030, O18389
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: October 1, 2000
Last modified: July 6, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.