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O16812 (PSA73_DROVI) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proteasome subunit alpha type-7-1B

EC=3.4.25.1
Alternative name(s):
Testis-specific proteasome 28 kDa subunit 1B
Gene names
Name:Pros28.1B
OrganismDrosophila virilis (Fruit fly)
Taxonomic identifier7244 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila

Protein attributes

Sequence length245 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Catalytic activity

Cleavage of peptide bonds with very broad specificity.

Subunit structure

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Tissue specificity

Testis specific.

Sequence similarities

Belongs to the peptidase T1A family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 245245Proteasome subunit alpha type-7-1B
PRO_0000124157

Sequences

Sequence LengthMass (Da)Tools
O16812 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: C44DF83375853971

FASTA24527,475
        10         20         30         40         50         60 
MSRFDESVNI YSDGHLLQVE YAQEAVRKGS TVGLRTKECV VLGVEKRAID SLQIERTSRK 

        70         80         90        100        110        120 
IKKIDQHMAM TFAGLTADAR VLVSRAQVEA QSHRLNFDRP ASVEYITRYL ARLKQTYTQS 

       130        140        150        160        170        180 
VARRPFGVSC LIGGFDEDGR PRLFQTDPSG IYYEWSANTT GRLGQTVNEY LEKNTAAISR 

       190        200        210        220        230        240 
TPDAASAMKH VVRALFTATS LDPASIELAV LRYWQPIEMV KPETLEYLLG VIKQEAVEEA 


LTKAP 

« Hide

References

[1]"Evolutionary conservation of a testes-specific proteasome subunit gene in Drosophila."
Belote J.M., Miller M., Smyth K.A.
Gene 215:93-100(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF017650 Genomic DNA. Translation: AAC34197.1.

3D structure databases

ProteinModelPortalO16812.
SMRO16812. Positions 4-243.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

FlyBaseFBgn0025404. Dvir\Pros28.1B.

Phylogenomic databases

eggNOGCOG0638.
InParanoidO16812.
OrthoDBEOG71VSTG.

Family and domain databases

Gene3D3.60.20.10. 1 hit.
InterProIPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
SUPFAMSSF56235. SSF56235. 1 hit.
PROSITEPS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePSA73_DROVI
AccessionPrimary (citable) accession number: O16812
Entry history
Integrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: January 1, 1998
Last modified: June 11, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase