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O16811 (PSA71_DROVI) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proteasome subunit alpha type-7-1

EC=3.4.25.1
Alternative name(s):
Proteasome 28 kDa subunit 1
Gene names
Name:Pros28.1
OrganismDrosophila virilis (Fruit fly)
Taxonomic identifier7244 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila

Protein attributes

Sequence length247 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Catalytic activity

Cleavage of peptide bonds with very broad specificity.

Subunit structure

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the peptidase T1A family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 247247Proteasome subunit alpha type-7-1
PRO_0000124156

Sequences

Sequence LengthMass (Da)Tools
O16811 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 8D31FA5DEA7269D7

FASTA24727,914
        10         20         30         40         50         60 
MSSRYDRAVT IFSPDGRLLQ VEYAQEAVRK GSTAVGVRGG NCVVLGVEKK SVAKLQEDRT 

        70         80         90        100        110        120 
VRKICVLDHV VMAFAGLTDA RILINRAQVE CQSHRLNVED PVTLEYITRY IAQLKQKYTQ 

       130        140        150        160        170        180 
SNGRRPFGIS CLIGGFDADG SPYLFQTEPS GIFYEYKANA TGCSAKTVRE FFEKQYREEE 

       190        200        210        220        230        240 
VSTERGAVKL AIRALLEVAQ SGQHNLEVAI MENGKPLKML DRKVILEYLD IIEKEKEEEL 


EKKKQKK 

« Hide

References

[1]"Evolutionary conservation of a testes-specific proteasome subunit gene in Drosophila."
Belote J.M., Miller M., Smyth K.A.
Gene 215:93-100(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF017649 Genomic DNA. Translation: AAC34196.1.

3D structure databases

ProteinModelPortalO16811.
SMRO16811. Positions 5-229.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7244.FBpp0232921.

Protein family/group databases

MEROPST01.973.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

FlyBaseFBgn0025405. Dvir\Pros28.1.

Phylogenomic databases

eggNOGCOG0638.
InParanoidO16811.
OrthoDBEOG71VSTG.

Family and domain databases

Gene3D3.60.20.10. 1 hit.
InterProIPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
SUPFAMSSF56235. SSF56235. 1 hit.
PROSITEPS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePSA71_DROVI
AccessionPrimary (citable) accession number: O16811
Entry history
Integrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: January 1, 1998
Last modified: June 11, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase