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O16811

- PSA71_DROVI

UniProt

O16811 - PSA71_DROVI

Protein

Proteasome subunit alpha type-7-1

Gene

Pros28.1

Organism
Drosophila virilis (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

    Catalytic activityi

    Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

    GO - Molecular functioni

    1. threonine-type endopeptidase activity Source: UniProtKB-KW

    GO - Biological processi

    1. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Threonine protease

    Protein family/group databases

    MEROPSiT01.973.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proteasome subunit alpha type-7-1 (EC:3.4.25.1)
    Alternative name(s):
    Proteasome 28 kDa subunit 1
    Gene namesi
    Name:Pros28.1
    OrganismiDrosophila virilis (Fruit fly)
    Taxonomic identifieri7244 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila

    Organism-specific databases

    FlyBaseiFBgn0025405. Dvir\Pros28.1.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell
    3. proteasome core complex, alpha-subunit complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Proteasome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 247247Proteasome subunit alpha type-7-1PRO_0000124156Add
    BLAST

    Interactioni

    Subunit structurei

    The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.By similarity

    Protein-protein interaction databases

    STRINGi7244.FBpp0232921.

    Structurei

    3D structure databases

    ProteinModelPortaliO16811.
    SMRiO16811. Positions 5-229.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase T1A family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0638.
    InParanoidiO16811.
    OrthoDBiEOG71VSTG.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    InterProiIPR029055. Ntn_hydrolases_N.
    IPR000426. Proteasome_asu_N.
    IPR023332. Proteasome_suA-type.
    IPR001353. Proteasome_sua/b.
    [Graphical view]
    PfamiPF00227. Proteasome. 1 hit.
    PF10584. Proteasome_A_N. 1 hit.
    [Graphical view]
    SMARTiSM00948. Proteasome_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    PROSITEiPS00388. PROTEASOME_ALPHA_1. 1 hit.
    PS51475. PROTEASOME_ALPHA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O16811-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSRYDRAVT IFSPDGRLLQ VEYAQEAVRK GSTAVGVRGG NCVVLGVEKK    50
    SVAKLQEDRT VRKICVLDHV VMAFAGLTDA RILINRAQVE CQSHRLNVED 100
    PVTLEYITRY IAQLKQKYTQ SNGRRPFGIS CLIGGFDADG SPYLFQTEPS 150
    GIFYEYKANA TGCSAKTVRE FFEKQYREEE VSTERGAVKL AIRALLEVAQ 200
    SGQHNLEVAI MENGKPLKML DRKVILEYLD IIEKEKEEEL EKKKQKK 247
    Length:247
    Mass (Da):27,914
    Last modified:January 1, 1998 - v1
    Checksum:i8D31FA5DEA7269D7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF017649 Genomic DNA. Translation: AAC34196.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF017649 Genomic DNA. Translation: AAC34196.1 .

    3D structure databases

    ProteinModelPortali O16811.
    SMRi O16811. Positions 5-229.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7244.FBpp0232921.

    Protein family/group databases

    MEROPSi T01.973.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    FlyBasei FBgn0025405. Dvir\Pros28.1.

    Phylogenomic databases

    eggNOGi COG0638.
    InParanoidi O16811.
    OrthoDBi EOG71VSTG.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    InterProi IPR029055. Ntn_hydrolases_N.
    IPR000426. Proteasome_asu_N.
    IPR023332. Proteasome_suA-type.
    IPR001353. Proteasome_sua/b.
    [Graphical view ]
    Pfami PF00227. Proteasome. 1 hit.
    PF10584. Proteasome_A_N. 1 hit.
    [Graphical view ]
    SMARTi SM00948. Proteasome_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    PROSITEi PS00388. PROTEASOME_ALPHA_1. 1 hit.
    PS51475. PROTEASOME_ALPHA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolutionary conservation of a testes-specific proteasome subunit gene in Drosophila."
      Belote J.M., Miller M., Smyth K.A.
      Gene 215:93-100(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiPSA71_DROVI
    AccessioniPrimary (citable) accession number: O16811
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 8, 2000
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3