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Protein

Origin recognition complex subunit 1

Gene

Orc1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi598 – 6058ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

  • cell proliferation Source: FlyBase
  • chromatin silencing Source: FlyBase
  • DNA amplification Source: FlyBase
  • DNA-dependent DNA replication Source: FlyBase
  • DNA replication initiation Source: FlyBase
  • neurogenesis Source: FlyBase
  • sensory perception of pain Source: FlyBase
Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-113510. E2F mediated regulation of DNA replication.
R-DME-176187. Activation of ATR in response to replication stress.
R-DME-68616. Assembly of the ORC complex at the origin of replication.
R-DME-68689. CDC6 association with the ORC:origin complex.
R-DME-68827. CDT1 association with the CDC6:ORC:origin complex.
R-DME-68867. Assembly of the pre-replicative complex.
R-DME-68949. Orc1 removal from chromatin.
R-DME-68962. Activation of the pre-replicative complex.
R-DME-69205. G1/S-Specific Transcription.
R-DME-69298. Association of licensing factors with the pre-replicative complex.
R-DME-69300. Removal of licensing factors from origins.

Names & Taxonomyi

Protein namesi
Recommended name:
Origin recognition complex subunit 1
Short name:
DmORC1
Gene namesi
Name:Orc1
ORF Names:CG10667
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0022772. Orc1.

Subcellular locationi

GO - Cellular componenti

  • nuclear origin of replication recognition complex Source: FlyBase
  • nucleus Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 924924Origin recognition complex subunit 1PRO_0000127069Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei293 – 2931Phosphoserine1 Publication
Modified residuei368 – 3681Phosphoserine1 Publication
Modified residuei419 – 4191Phosphothreonine1 Publication
Modified residuei426 – 4261Phosphoserine1 Publication
Modified residuei430 – 4301Phosphoserine1 Publication
Modified residuei533 – 5331Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO16810.
PRIDEiO16810.

PTM databases

iPTMnetiO16810.

Expressioni

Gene expression databases

BgeeiFBgn0022772.
GenevisibleiO16810. DM.

Interactioni

Subunit structurei

ORC is composed of six subunits.By similarity

Protein-protein interaction databases

BioGridi61562. 3 interactions.
DIPiDIP-59662N.
IntActiO16810. 3 interactions.
STRINGi7227.FBpp0088033.

Structurei

Secondary structure

1
924
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi573 – 58816Combined sources
Beta strandi594 – 5985Combined sources
Helixi600 – 6023Combined sources
Helixi604 – 61411Combined sources
Beta strandi629 – 6335Combined sources
Turni634 – 6363Combined sources
Helixi640 – 6423Combined sources
Helixi643 – 6519Combined sources
Beta strandi652 – 6543Combined sources
Helixi658 – 66710Combined sources
Beta strandi680 – 6845Combined sources
Helixi686 – 6927Combined sources
Helixi695 – 70511Combined sources
Beta strandi712 – 7187Combined sources
Turni722 – 7254Combined sources
Beta strandi738 – 7425Combined sources
Helixi747 – 75812Combined sources
Helixi768 – 78013Combined sources
Helixi783 – 79917Combined sources
Helixi807 – 81812Combined sources
Helixi821 – 8288Combined sources
Helixi831 – 84717Combined sources
Helixi854 – 86815Combined sources
Helixi875 – 88713Combined sources
Beta strandi890 – 8934Combined sources
Turni895 – 9017Combined sources
Beta strandi903 – 9064Combined sources
Helixi910 – 9178Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4XGCX-ray3.50A533-924[»]
ProteinModelPortaliO16810.
SMRiO16810. Positions 569-919.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 187143BAHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ORC1 family.Curated
Contains 1 BAH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1514. Eukaryota.
COG1474. LUCA.
GeneTreeiENSGT00530000063498.
InParanoidiO16810.
KOiK02603.
OMAiCENKVSP.
OrthoDBiEOG091G0BA1.
PhylomeDBiO16810.

Family and domain databases

CDDicd08768. Cdc6_C. 1 hit.
Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR001025. BAH_dom.
IPR015163. Cdc6_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF01426. BAH. 1 hit.
PF09079. Cdc6_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00439. BAH. 1 hit.
SM01074. Cdc6_C. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51038. BAH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O16810-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNKENARSV GQQVKWIGSQ DELPPVKNLE HKNVYFYQKC IYGPLTLSVG
60 70 80 90 100
DFILVSNADA AEPDTVSGCD VARILHMYEL RELTDREPCR AIVQWYSWPK
110 120 130 140 150
AIPHNKYDDD EVAIDFSLEV IEEHRPYDND VALGAIYRKC IVLEGTSKTS
160 170 180 190 200
AEEILKRHAN KLKSTACPMF VSRYRFVKVK RSYRLIPLEI HLEQPEDNAR
210 220 230 240 250
PTRSSRKSLT AHRESKRSIS ARHDDTAGNK GSSVEKRRRA SMAASSSVEF
260 270 280 290 300
IDVNSFICEN KVSPIKIVGG RSVVRLSEKK NAPEINANYL PASPLTEKNA
310 320 330 340 350
KVETPKSRAS AARRNLNLSL DRGADTTADS DCLNYSIVQQ TPDPKTPSND
360 370 380 390 400
MKIKLRLSER RRSVRLASMD VDPLSLEEAV QEPNAQGRKR LGVANGDIYH
410 420 430 440 450
TPTKKSKEPL ESAAATEQTP STRRKSILKS ATSRLAEGTP RRSIHLSNIV
460 470 480 490 500
EQRVFEDDEI ISTPKRGRSK KTVQDNDEDY SPKKSVQKTP TRTRRSSTTT
510 520 530 540 550
KTATTPSKGI TTATATPMTP SQKMKKIRAG ELSPSMQQRT DLPAKDSSKS
560 570 580 590 600
ELQLAREQLH VSVVPKSLPC REREFENIYA FLEGKIQDQC GGCMYVSGVP
610 620 630 640 650
GTGKTATVTG VIRTLQRMAK QNELPAFEYL EINGMRLTEP RQAYVQIYKQ
660 670 680 690 700
LTGKTVSWEQ AHALLEKRFT TPAPRRVTTV LLVDELDILC NRRQDVVYNL
710 720 730 740 750
LDWPTKSAAK LVVVTIANTM DLPERLLMGK VTSRLGLTRL TFQPYSHKQL
760 770 780 790 800
QEIVTARLGG SETFKGEAVQ LVARKVAAVS GDARRALDIC RRATEIADTA
810 820 830 840 850
AVKCVTMLHV QQALAEMIAS AKVQAIRNCS RMEQIFLQAI AAEVTRTGVE
860 870 880 890 900
ETTFMGVYQQ VETIAAFMGV TFPPPGRALR LCSKLGAERL IISEHSRNDL
910 920
FQKILLNVSA DDIHYALRVE EMVN
Length:924
Mass (Da):103,281
Last modified:February 21, 2001 - v2
Checksum:iAACD002DEB10A136
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti159 – 1591A → S in AAC47802 (PubMed:9363940).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017647 mRNA. Translation: AAC47802.1.
AE013599 Genomic DNA. Translation: AAF59236.1.
AY094780 mRNA. Translation: AAM11133.1.
RefSeqiNP_477303.1. NM_057955.4.
UniGeneiDm.2266.

Genome annotation databases

EnsemblMetazoaiFBtr0088959; FBpp0088033; FBgn0022772.
GeneIDi35686.
KEGGidme:Dmel_CG10667.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017647 mRNA. Translation: AAC47802.1.
AE013599 Genomic DNA. Translation: AAF59236.1.
AY094780 mRNA. Translation: AAM11133.1.
RefSeqiNP_477303.1. NM_057955.4.
UniGeneiDm.2266.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4XGCX-ray3.50A533-924[»]
ProteinModelPortaliO16810.
SMRiO16810. Positions 569-919.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi61562. 3 interactions.
DIPiDIP-59662N.
IntActiO16810. 3 interactions.
STRINGi7227.FBpp0088033.

PTM databases

iPTMnetiO16810.

Proteomic databases

PaxDbiO16810.
PRIDEiO16810.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0088959; FBpp0088033; FBgn0022772.
GeneIDi35686.
KEGGidme:Dmel_CG10667.

Organism-specific databases

CTDi4998.
FlyBaseiFBgn0022772. Orc1.

Phylogenomic databases

eggNOGiKOG1514. Eukaryota.
COG1474. LUCA.
GeneTreeiENSGT00530000063498.
InParanoidiO16810.
KOiK02603.
OMAiCENKVSP.
OrthoDBiEOG091G0BA1.
PhylomeDBiO16810.

Enzyme and pathway databases

ReactomeiR-DME-113510. E2F mediated regulation of DNA replication.
R-DME-176187. Activation of ATR in response to replication stress.
R-DME-68616. Assembly of the ORC complex at the origin of replication.
R-DME-68689. CDC6 association with the ORC:origin complex.
R-DME-68827. CDT1 association with the CDC6:ORC:origin complex.
R-DME-68867. Assembly of the pre-replicative complex.
R-DME-68949. Orc1 removal from chromatin.
R-DME-68962. Activation of the pre-replicative complex.
R-DME-69205. G1/S-Specific Transcription.
R-DME-69298. Association of licensing factors with the pre-replicative complex.
R-DME-69300. Removal of licensing factors from origins.

Miscellaneous databases

GenomeRNAii35686.
PROiO16810.

Gene expression databases

BgeeiFBgn0022772.
GenevisibleiO16810. DM.

Family and domain databases

CDDicd08768. Cdc6_C. 1 hit.
Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR001025. BAH_dom.
IPR015163. Cdc6_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF01426. BAH. 1 hit.
PF09079. Cdc6_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00439. BAH. 1 hit.
SM01074. Cdc6_C. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51038. BAH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiORC1_DROME
AccessioniPrimary (citable) accession number: O16810
Secondary accession number(s): Q9V4N1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: February 21, 2001
Last modified: September 7, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.