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Protein
Submitted name:

CYtochrome P450 family

Gene

cyp-33c5

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

MonooxygenaseUniRule annotation, Oxidoreductase

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-CEL-156581. Methylation.
R-CEL-193048. Androgen biosynthesis.
R-CEL-193993. Mineralocorticoid biosynthesis.
R-CEL-194002. Glucocorticoid biosynthesis.
R-CEL-211957. Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2.
R-CEL-211976. Endogenous sterols.
R-CEL-211981. Xenobiotics.
R-CEL-2142670. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
R-CEL-2142816. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
R-CEL-5423646. Aflatoxin activation and detoxification.

Names & Taxonomyi

Protein namesi
Submitted name:
CYtochrome P450 familyImported
Gene namesi
Name:cyp-33c5Imported
Synonyms:cyp-33C5Imported
ORF Names:CELE_F41B5.3Imported, F41B5.3Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiF41B5.3a; CE27379; WBGene00018261; cyp-33C5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 494470Sequence analysisPRO_5004157311Add
BLAST

Proteomic databases

EPDiO16671.
PaxDbiO16671.
PRIDEiO16671.

Expressioni

Gene expression databases

ExpressionAtlasiO16671. baseline.

Interactioni

Protein-protein interaction databases

STRINGi6239.F41B5.3.

Structurei

3D structure databases

ProteinModelPortaliO16671.
SMRiO16671. Positions 25-464.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000036993.
InParanoidiO16671.
KOiK17955.
OrthoDBiEOG7RBZ85.
PhylomeDBiO16671.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O16671-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILLLLSAAV CLFLFHELYW KRRSLPPGPT PLPFMGNTLA MLLEKPGYEC
60 70 80 90 100
FRRWTKQFGG VYTFWMGNIP YVIIGSYDLL KETFVRDGDT YKDKYPQPFN
110 120 130 140 150
EKLRGGMYGI VESNGHMWST HRRFALSTLR DFGLGKDLMQ EKILIEVEDI
160 170 180 190 200
FRKYDAQLGK EQDIQVVLNN AIANVINQTI FGYRFDETNQ EEFERMRHLV
210 220 230 240 250
EYQEKQFATV KVYVEAFVPT IGKFLPGKSL DQLLDDWRNS FYTFFDTQIE
260 270 280 290 300
NHRKKIDFDS EESQDYAEAY LKEQKKQEAL GEFELFSNTQ FSNTCLDLWL
310 320 330 340 350
AGVSTTNTTV NWTICYVLNH PDVLQKMNEE FDQVVGSDRL VTMGDKNNLP
360 370 380 390 400
YFNAVLNESQ RCANIVPINL FHATTKDTVI NGYPVKKGTG VIAQISTVML
410 420 430 440 450
DEKIFPEPYK FNPDRFIDEN GKPIKIEQLI PFSIGKRQCP GEGLARMEIF
460 470 480 490
LFLANFFNRY KISPSSKVFP NLDKKDNVGV FPKDLHAILN RRNC
Length:494
Mass (Da):57,323
Last modified:October 1, 2001 - v2
Checksum:i84C48770C6C65AFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CCD70986.1.
RefSeqiNP_503616.1. NM_071215.3.
UniGeneiCel.3628.

Genome annotation databases

EnsemblMetazoaiF41B5.3; F41B5.3; WBGene00018261.
F41B5.3a; F41B5.3a; WBGene00018261.
GeneIDi178706.
KEGGicel:CELE_F41B5.3.
UCSCiF41B5.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CCD70986.1.
RefSeqiNP_503616.1. NM_071215.3.
UniGeneiCel.3628.

3D structure databases

ProteinModelPortaliO16671.
SMRiO16671. Positions 25-464.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F41B5.3.

Proteomic databases

EPDiO16671.
PaxDbiO16671.
PRIDEiO16671.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF41B5.3; F41B5.3; WBGene00018261.
F41B5.3a; F41B5.3a; WBGene00018261.
GeneIDi178706.
KEGGicel:CELE_F41B5.3.
UCSCiF41B5.3. c. elegans.

Organism-specific databases

CTDi178706.
WormBaseiF41B5.3a; CE27379; WBGene00018261; cyp-33C5.

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000036993.
InParanoidiO16671.
KOiK17955.
OrthoDBiEOG7RBZ85.
PhylomeDBiO16671.

Enzyme and pathway databases

ReactomeiR-CEL-156581. Methylation.
R-CEL-193048. Androgen biosynthesis.
R-CEL-193993. Mineralocorticoid biosynthesis.
R-CEL-194002. Glucocorticoid biosynthesis.
R-CEL-211957. Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2.
R-CEL-211976. Endogenous sterols.
R-CEL-211981. Xenobiotics.
R-CEL-2142670. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
R-CEL-2142816. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
R-CEL-5423646. Aflatoxin activation and detoxification.

Gene expression databases

ExpressionAtlasiO16671. baseline.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiO16671_CAEEL
AccessioniPrimary (citable) accession number: O16671
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: October 1, 2001
Last modified: July 6, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.