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O16581

- GLCM2_CAEEL

UniProt

O16581 - GLCM2_CAEEL

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Protein

Putative glucosylceramidase 2

Gene

gba-2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei254 – 2541Proton donorBy similarity
Active sitei358 – 3581NucleophileBy similarity

GO - Molecular functioni

  1. glucosylceramidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. sphingolipid metabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid metabolism, Sphingolipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00222.

Protein family/group databases

CAZyiGH30. Glycoside Hydrolase Family 30.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative glucosylceramidase 2 (EC:3.2.1.45)
Gene namesi
Name:gba-2
ORF Names:C33C12.8
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome II

Organism-specific databases

WormBaseiC33C12.8; CE41877; WBGene00016340; gba-2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 516493Putative glucosylceramidase 2PRO_0000421454Add
BLAST

Proteomic databases

PaxDbiO16581.
PRIDEiO16581.

Interactioni

Protein-protein interaction databases

DIPiDIP-25825N.
MINTiMINT-1040113.
STRINGi6239.C33C12.8.

Structurei

3D structure databases

ProteinModelPortaliO16581.
SMRiO16581. Positions 22-492.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 30 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5520.
GeneTreeiENSGT00390000009464.
HOGENOMiHOG000270031.
InParanoidiO16581.
KOiK01201.
OMAiISESCIG.
OrthoDBiEOG76DTRZ.
PhylomeDBiO16581.

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR013780. Glyco_hydro_13_b.
IPR001139. Glyco_hydro_30.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR11069. PTHR11069. 1 hit.
PfamiPF02055. Glyco_hydro_30. 1 hit.
[Graphical view]
PRINTSiPR00843. GLHYDRLASE30.
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O16581-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSIAWSCFVL GLFALASLQV ALANDCAQKT FKTGIVCVCN ITYCDEIPDI
60 70 80 90 100
NLLSGQAATF TTSKSGARLH RDVVYATNSD PLTSMHFTID SSKTYQTIQG
110 120 130 140 150
FGSTFSDASG ANLKSLPDQM ADTILRQYFS DSGLNLQFGR VPIASNDFSS
160 170 180 190 200
RVYTYDDNLE DYNMAHFSLQ REDYQWKIPY MQMAQKYNHD LKFFAVPWSA
210 220 230 240 250
PGWLKTTNST KGYGILLGTN QDTYHKSYVT YILHFLEEYQ KNGILFWGLS
260 270 280 290 300
TQNEPTSGSD KKTKMQSMGF TAEFQRDFIK LDIGPALKSS NAGKNVKILI
310 320 330 340 350
LDDNRGNLPK WADTVLNDKD AASYVSGIAV HSYQDDESDK HLTQTHNNHP
360 370 380 390 400
DVFIFGTEAS EGSKSKDVDY GSFDRAEDYV SDILDDFNNW VTGWTERNLV
410 420 430 440 450
LDAQGGPSWV SGFADAPVIA FPALAQFYKQ PMFYAIAHFS HFLKPGAVRI
460 470 480 490 500
DHSLNMPNPE IERSAFLNPD GSKVVVLHNK NPLAPYSLSI KDTMKSTDHY
510
QVHLSPKTIV TLYIQN
Length:516
Mass (Da):57,783
Last modified:February 5, 2008 - v2
Checksum:iD7A02EB80C218ED6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080754 Genomic DNA. Translation: CCD66456.1.
RefSeqiNP_494208.2. NM_061807.5.
UniGeneiCel.15726.

Genome annotation databases

EnsemblMetazoaiC33C12.8; C33C12.8; WBGene00016340.
GeneIDi183155.
KEGGicel:CELE_C33C12.8.
UCSCiC33C12.8. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080754 Genomic DNA. Translation: CCD66456.1 .
RefSeqi NP_494208.2. NM_061807.5.
UniGenei Cel.15726.

3D structure databases

ProteinModelPortali O16581.
SMRi O16581. Positions 22-492.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-25825N.
MINTi MINT-1040113.
STRINGi 6239.C33C12.8.

Protein family/group databases

CAZyi GH30. Glycoside Hydrolase Family 30.

Proteomic databases

PaxDbi O16581.
PRIDEi O16581.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai C33C12.8 ; C33C12.8 ; WBGene00016340 .
GeneIDi 183155.
KEGGi cel:CELE_C33C12.8.
UCSCi C33C12.8. c. elegans.

Organism-specific databases

CTDi 183155.
WormBasei C33C12.8 ; CE41877 ; WBGene00016340 ; gba-2.

Phylogenomic databases

eggNOGi COG5520.
GeneTreei ENSGT00390000009464.
HOGENOMi HOG000270031.
InParanoidi O16581.
KOi K01201.
OMAi ISESCIG.
OrthoDBi EOG76DTRZ.
PhylomeDBi O16581.

Enzyme and pathway databases

UniPathwayi UPA00222 .

Miscellaneous databases

NextBioi 920114.

Family and domain databases

Gene3Di 2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR013780. Glyco_hydro_13_b.
IPR001139. Glyco_hydro_30.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR11069. PTHR11069. 1 hit.
Pfami PF02055. Glyco_hydro_30. 1 hit.
[Graphical view ]
PRINTSi PR00843. GLHYDRLASE30.
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiGLCM2_CAEEL
AccessioniPrimary (citable) accession number: O16581
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2013
Last sequence update: February 5, 2008
Last modified: October 1, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3