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O16581

- GLCM2_CAEEL

UniProt

O16581 - GLCM2_CAEEL

Protein

Putative glucosylceramidase 2

Gene

gba-2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 2 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei254 – 2541Proton donorBy similarity
    Active sitei358 – 3581NucleophileBy similarity

    GO - Molecular functioni

    1. glucosylceramidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. sphingolipid metabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid metabolism, Sphingolipid metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00222.

    Protein family/group databases

    CAZyiGH30. Glycoside Hydrolase Family 30.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative glucosylceramidase 2 (EC:3.2.1.45)
    Gene namesi
    Name:gba-2
    ORF Names:C33C12.8
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome II

    Organism-specific databases

    WormBaseiC33C12.8; CE41877; WBGene00016340; gba-2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 516493Putative glucosylceramidase 2PRO_0000421454Add
    BLAST

    Proteomic databases

    PaxDbiO16581.
    PRIDEiO16581.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-25825N.
    MINTiMINT-1040113.
    STRINGi6239.C33C12.8.

    Structurei

    3D structure databases

    ProteinModelPortaliO16581.
    SMRiO16581. Positions 22-492.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 30 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5520.
    GeneTreeiENSGT00390000009464.
    HOGENOMiHOG000270031.
    InParanoidiO16581.
    KOiK01201.
    OMAiISESCIG.
    OrthoDBiEOG76DTRZ.
    PhylomeDBiO16581.

    Family and domain databases

    Gene3Di2.60.40.1180. 1 hit.
    3.20.20.80. 1 hit.
    InterProiIPR013780. Glyco_hydro_13_b.
    IPR001139. Glyco_hydro_30.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR11069. PTHR11069. 1 hit.
    PfamiPF02055. Glyco_hydro_30. 1 hit.
    [Graphical view]
    PRINTSiPR00843. GLHYDRLASE30.
    SUPFAMiSSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O16581-1 [UniParc]FASTAAdd to Basket

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    MSIAWSCFVL GLFALASLQV ALANDCAQKT FKTGIVCVCN ITYCDEIPDI    50
    NLLSGQAATF TTSKSGARLH RDVVYATNSD PLTSMHFTID SSKTYQTIQG 100
    FGSTFSDASG ANLKSLPDQM ADTILRQYFS DSGLNLQFGR VPIASNDFSS 150
    RVYTYDDNLE DYNMAHFSLQ REDYQWKIPY MQMAQKYNHD LKFFAVPWSA 200
    PGWLKTTNST KGYGILLGTN QDTYHKSYVT YILHFLEEYQ KNGILFWGLS 250
    TQNEPTSGSD KKTKMQSMGF TAEFQRDFIK LDIGPALKSS NAGKNVKILI 300
    LDDNRGNLPK WADTVLNDKD AASYVSGIAV HSYQDDESDK HLTQTHNNHP 350
    DVFIFGTEAS EGSKSKDVDY GSFDRAEDYV SDILDDFNNW VTGWTERNLV 400
    LDAQGGPSWV SGFADAPVIA FPALAQFYKQ PMFYAIAHFS HFLKPGAVRI 450
    DHSLNMPNPE IERSAFLNPD GSKVVVLHNK NPLAPYSLSI KDTMKSTDHY 500
    QVHLSPKTIV TLYIQN 516
    Length:516
    Mass (Da):57,783
    Last modified:February 5, 2008 - v2
    Checksum:iD7A02EB80C218ED6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080754 Genomic DNA. Translation: CCD66456.1.
    RefSeqiNP_494208.2. NM_061807.5.
    UniGeneiCel.15726.

    Genome annotation databases

    EnsemblMetazoaiC33C12.8; C33C12.8; WBGene00016340.
    GeneIDi183155.
    KEGGicel:CELE_C33C12.8.
    UCSCiC33C12.8. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080754 Genomic DNA. Translation: CCD66456.1 .
    RefSeqi NP_494208.2. NM_061807.5.
    UniGenei Cel.15726.

    3D structure databases

    ProteinModelPortali O16581.
    SMRi O16581. Positions 22-492.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-25825N.
    MINTi MINT-1040113.
    STRINGi 6239.C33C12.8.

    Protein family/group databases

    CAZyi GH30. Glycoside Hydrolase Family 30.

    Proteomic databases

    PaxDbi O16581.
    PRIDEi O16581.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai C33C12.8 ; C33C12.8 ; WBGene00016340 .
    GeneIDi 183155.
    KEGGi cel:CELE_C33C12.8.
    UCSCi C33C12.8. c. elegans.

    Organism-specific databases

    CTDi 183155.
    WormBasei C33C12.8 ; CE41877 ; WBGene00016340 ; gba-2.

    Phylogenomic databases

    eggNOGi COG5520.
    GeneTreei ENSGT00390000009464.
    HOGENOMi HOG000270031.
    InParanoidi O16581.
    KOi K01201.
    OMAi ISESCIG.
    OrthoDBi EOG76DTRZ.
    PhylomeDBi O16581.

    Enzyme and pathway databases

    UniPathwayi UPA00222 .

    Miscellaneous databases

    NextBioi 920114.

    Family and domain databases

    Gene3Di 2.60.40.1180. 1 hit.
    3.20.20.80. 1 hit.
    InterProi IPR013780. Glyco_hydro_13_b.
    IPR001139. Glyco_hydro_30.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR11069. PTHR11069. 1 hit.
    Pfami PF02055. Glyco_hydro_30. 1 hit.
    [Graphical view ]
    PRINTSi PR00843. GLHYDRLASE30.
    SUPFAMi SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiGLCM2_CAEEL
    AccessioniPrimary (citable) accession number: O16581
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 6, 2013
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3