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Protein

Receptor-type guanylate cyclase gcy-19

Gene

gcy-19

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Guanylate cyclase involved in the production of the second messenger cGMP (By similarity).By similarity

Catalytic activityi

GTP = 3',5'-cyclic GMP + diphosphate.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase, Receptor
Biological processcGMP biosynthesis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiO16544

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type guanylate cyclase gcy-19Curated (EC:4.6.1.2By similarity)
Gene namesi
Name:gcy-19Imported
ORF Names:C17F4.6Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiC17F4.6 ; CE45028 ; WBGene00001544 ; gcy-19

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 507ExtracellularSequence analysisAdd BLAST483
Transmembranei508 – 528HelicalSequence analysisAdd BLAST21
Topological domaini529 – 1182CytoplasmicSequence analysisAdd BLAST654

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000043328825 – 1182Receptor-type guanylate cyclase gcy-19Sequence analysisAdd BLAST1158

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi91N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi369N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi430N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi453N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO16544

Expressioni

Tissue specificityi

Expressed in IL2 sensory neurons.1 Publication

Gene expression databases

BgeeiWBGene00001544

Interactioni

Protein-protein interaction databases

STRINGi6239.C17F4.6

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini562 – 849Protein kinasePROSITE-ProRule annotationAdd BLAST288
Domaini907 – 1037Guanylate cyclasePROSITE-ProRule annotationAdd BLAST131

Domaini

The protein kinase domain is predicted to be catalytically inactive.PROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1023 Eukaryota
COG0515 LUCA
COG2114 LUCA
GeneTreeiENSGT00760000118959
HOGENOMiHOG000016255
InParanoidiO16544
OMAiTNIMANS
OrthoDBiEOG091G02QS

Family and domain databases

Gene3Di3.30.70.1230, 1 hit
InterProiView protein in InterPro
IPR001054 A/G_cyclase
IPR018297 A/G_cyclase_CS
IPR001828 ANF_lig-bd_rcpt
IPR011009 Kinase-like_dom_sf
IPR029787 Nucleotide_cyclase
IPR028082 Peripla_BP_I
IPR000719 Prot_kinase_dom
PfamiView protein in Pfam
PF01094 ANF_receptor, 1 hit
PF00211 Guanylate_cyc, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00044 CYCc, 1 hit
SUPFAMiSSF53822 SSF53822, 1 hit
SSF55073 SSF55073, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00452 GUANYLATE_CYCLASE_1, 1 hit
PS50125 GUANYLATE_CYCLASE_2, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O16544-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYLLFLLLF AGFLTFLPRF LIYAQITSST TTTTPVPAAN RRTIRVGVAA
60 70 80 90 100
VQTTELDSIG WPMSGGAINM AIQKLRDDGF IAPFDFEVTV NYTECDRSLG
110 120 130 140 150
AAVGMEFMRT KRLDVVIGPP CRDPMEIMAT MATYYSTPML GWGLVTDSKF
160 170 180 190 200
TDTERYPYLT NIMANSLSLG FSLVKLLEMM EWDRVALVYE ESAQDYPLSV
210 220 230 240 250
INDVETAINE YDTFAVNVVV KQALPGGDLN DAQYISVLNR IKLRCRIIVS
260 270 280 290 300
VFQTAPTRRR YLKMIDQQGM ANEEYVHILL GLRSIGFGKQ SAGLTKCELN
310 320 330 340 350
CLSSGLAPFW DIAPDDGLND RLKQAATRML VMDLSTDVPD INYLNTFTMN
360 370 380 390 400
CGAVVVNPPV SCATPACINA STSPPSAFAR SLHDVFYLYG LAITNLYNQD
410 420 430 440 450
PAYLNDIDKI NGALQLNFAG LTGEVSINAN NSRVPKLMLY ALNDKYDQAS
460 470 480 490 500
FMNLTYSLNG GAVSVSLAYT NEASLWYWYG GKRPLSVPVC GFAGTDCPQS
510 520 530 540 550
FVDQYGALVF AIGGVLIFAM LFVITCFFYV MRQKRLERDR IDAEWQIPLV
560 570 580 590 600
KLQAPPKRDK ERMSKRSLQS GPSNITDTSK MTFDNTFSNY SIFYLDKEPV
610 620 630 640 650
LSTAHPASNL IRTDYDTFVR LRKLDHENVN KFVGMSIDGP EYLAVWKLCM
660 670 680 690 700
RGSLQDIIGQ GNFSIDPFFM FCVIRDMAEG LKYLHNSFLH VHANLRSGTV
710 720 730 740 750
LVNESWQAKL TDFGLGTLAE EKKPMKRRQL WMAPEVIRGT LLPHQIEKSA
760 770 780 790 800
DIYSLAVIAS EVLTRKEAWN MAERKDTVDE IVYRIKKGGP NAPRPELDMD
810 820 830 840 850
GVEINHNLLI LIRDCWSEEP ADRPSADVIC NLLKNMMPKK GNLMDHVFNI
860 870 880 890 900
LEDYTTNLEV EVEDRTKELT AEKKKADVLL GRMLPKQVAE RLKQGQTVEP
910 920 930 940 950
EGFDSVTVFF SDVVKFTQLA AKCSPFQVVN LLNDLYSNFD AIIEEHGCYK
960 970 980 990 1000
VESIGDGYLC VSGLPSKNGN AHIKQIVELS LDFMSYCKSF KIPHLPREKV
1010 1020 1030 1040 1050
ELRIGVNSGP CVAGVVGLSM PRYCLFGDTV NTASRMESNG KASHIHLSAA
1060 1070 1080 1090 1100
SYTLLMKHYP NQYNTASRGD VIIKGKGVME TFWVFERNNQ FMGVSSNSGY
1110 1120 1130 1140 1150
QSDKKATNNG SSPESTPPST PPMHEVKANS PVRHRKPPSP SSPTLSKRSV
1160 1170 1180
SPIMEAKARD IHNEETEALY RQFRRQETLA LI
Length:1,182
Mass (Da):132,247
Last modified:January 25, 2012 - v4
Checksum:i35E4D8C0B0060F3F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA Translation: CCD64916.1
RefSeqiNP_494491.4, NM_062090.6
UniGeneiCel.14879

Genome annotation databases

EnsemblMetazoaiC17F4.6; C17F4.6; WBGene00001544
GeneIDi191650
KEGGicel:CELE_C17F4.6
UCSCiC17F4.6 c. elegans

Similar proteinsi

Entry informationi

Entry nameiGCY19_CAEEL
AccessioniPrimary (citable) accession number: O16544
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 24, 2015
Last sequence update: January 25, 2012
Last modified: April 25, 2018
This is version 146 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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