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Protein

NADH-cytochrome b5 reductase

Gene

CELE_T05H4.4

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

NADH + 2 ferricytochrome b5 = NAD+ + H+ + 2 ferrocytochrome b5.UniRule annotation

Cofactori

FADUniRule annotationSAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation
LigandFADUniRule annotationSAAS annotation, Flavoprotein, NADUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-CEL-114608. Platelet degranulation.
R-CEL-1237044. Erythrocytes take up carbon dioxide and release oxygen.
R-CEL-196836. Vitamin C (ascorbate) metabolism.
R-CEL-211945. Phase I - Functionalization of compounds.
R-CEL-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-cytochrome b5 reductaseUniRule annotation (EC:1.6.2.2UniRule annotation)
Gene namesi
ORF Names:CELE_T05H4.4Imported, T05H4.4Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiT05H4.4; CE13275; WBGene00020267.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 25HelicalSequence analysisAdd BLAST20
Transmembranei173 – 197HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

EPDiO16522.
PaxDbiO16522.
PeptideAtlasiO16522.

Expressioni

Gene expression databases

BgeeiWBGene00020267.

Interactioni

Protein-protein interaction databases

STRINGi6239.T05H4.4.

Structurei

3D structure databases

ProteinModelPortaliO16522.
SMRiO16522.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 154FAD-binding FR-typeInterPro annotationAdd BLAST113

Sequence similaritiesi

Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0534. Eukaryota.
COG0543. LUCA.
GeneTreeiENSGT00390000008881.
HOGENOMiHOG000175005.
InParanoidiO16522.
KOiK00326.
OMAiNGPMSTH.
OrthoDBiEOG091G0EIS.
PhylomeDBiO16522.

Family and domain databases

InterProiView protein in InterPro
IPR017927. Fd_Rdtase_FAD-bd.
IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
IPR001834. NADH-Cyt_B5_reductase.
IPR008333. OxRdtase_FAD-bd_dom.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR017938. Riboflavin_synthase-like_b-brl.
PfamiView protein in Pfam
PF00970. FAD_binding_6. 1 hit.
PF00175. NAD_binding_1. 1 hit.
PRINTSiPR00406. CYTB5RDTASE.
PR00371. FPNCR.
SUPFAMiSSF63380. SSF63380. 1 hit.
PROSITEiView protein in PROSITE
PS51384. FAD_FR. 1 hit.

Sequencei

Sequence statusi: Complete.

O16522-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVENNTLAIT GGVVLISSVS LFLYLRQLRA EKKSKRTLED DSVKYLLPLI
60 70 80 90 100
EKFEISHNTR KFRFGLPSKD HILGLPIGHH VYLSANIGGK LIVRSYTPVS
110 120 130 140 150
CDLDLGYVDL MVKVYFKNTH ERFPDGGKMS QHLESLKIGD TVSFRGPHGS
160 170 180 190 200
IIYKGSGLFT VRMDKKAEPK NRFFKHLSMI AGGTGITPML QVIAAILRDP
210 220 230 240 250
IDATQIRLLF ANQTEDDILC RKELDELAEK HPTRFRVWYT VSKASKDWRY
260 270 280 290 300
STGHINEEMI KEHLFPSNEE SAVLLCGPPA MINCACIPNL DKLGHNSENY

LIF
Length:303
Mass (Da):34,264
Last modified:January 1, 1998 - v1
Checksum:i28F83123C650FD84
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CCD72031.1.
PIRiT31909.
RefSeqiNP_504639.1. NM_072238.1.
UniGeneiCel.2462.

Genome annotation databases

EnsemblMetazoaiT05H4.4; T05H4.4; WBGene00020267.
GeneIDi188150.
KEGGicel:CELE_T05H4.4.
UCSCiT05H4.4. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiO16522_CAEEL
AccessioniPrimary (citable) accession number: O16522
Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: August 30, 2017
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported